[1]李 燕,陈 晨.3503例抑郁症患者血清自身抗体谱的表达及与预后的相关性分析[J].现代检验医学杂志,2026,41(03):69-74.[doi:10.3969/j.issn.1671-7414.2026.03.013]
　LI Yan,CHEN Chen.Expression Profiles of Serum Autoantibodies and Their Prognostic Correlation in 3 503 Patients with Depression[J].Journal of Modern Laboratory Medicine,2026,41(03):69-74.[doi:10.3969/j.issn.1671-7414.2026.03.013]
点击复制

3503例抑郁症患者血清自身抗体谱的表达及与预后的相关性分析()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第41卷
期数:
2026年03期
页码:
69-74
栏目:
论著
出版日期:
2026-05-13

文章信息/Info

Title:
Expression Profiles of Serum Autoantibodies and Their Prognostic Correlation in 3 503 Patients with Depression
文章编号:
1671-7414（2026）03-069-06
作者:
李 燕，陈 晨
南京医科大学附属脑科医院检验科，南京 210029
Author(s):
LI Yan，CHEN Chen
Department of Clinical Laboratory, Brain Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210029, China
关键词:
抑郁症; 自身抗体; 汉密尔顿抑郁量表-24
分类号:
R749.4；R392.11
DOI:
10.3969/j.issn.1671-7414.2026.03.013
文献标志码:
A
摘要:
目的?探讨血清自身抗体谱在抑郁症患者中的表达特征及与抑郁症患者预后的相关性。方法选取2018年7月～2024年3月南京医科大学附属脑科医院诊治的3503例抑郁症患者作为研究对象，采用免疫印迹法（Westernblotting）检测血清自身抗体谱的表达，并收集患者临床资料。选取资料完整的115例血清自身抗体谱阳性的抑郁症患者作为观察组，以同期86例血清自身抗体谱阴性的抑郁症患者作为对照组。以汉密尔顿抑郁量表（HAMD）-24减分率评估疗效；采用Spearman相关性分析HAMD-24与自身抗体谱的相关性；Logistic回归分析抑郁症患者预后的影响因素。结果抑郁症患者中血清自身抗体谱阳性率为4.80%（168/3503），其中抗SSA抗体（SSA52和SSA60）阳性率最高4.00%（140/3503）。与对照组相比，观察组血糖（GLU）水平显著降低（4.85±0.87mmol/Lvs5.06±0.78mmol/L），差异具有统计学意义（t=2.900，P<0.01）；其他临床指标、治疗前后HAMD-24总分和自杀风险评分差异无统计学意义（t/Z=0.100～2.900，均P>0.05）。与中度抑郁组（8.11%）相比，轻度组（31.82%）和重度组（32.14%）血清抗环胍氨酸肽抗体（抗CCP）的阳性率升高，差异具有统计学意义（χ2=5.510、7.362，均P<0.05）。Spearman分析患者入院时HAMD-24总分与血清抗Jo-1抗体的表达呈负相关（r=-0.15，P<0.05），治疗4周后HAMD-24总分与血清抗SSA52抗体的表达呈正相关（r=0.14，P<0.05）。多因素分析显示，GLU是影响自身抗体谱阳性的抑郁症患者的独立预后因素。结论抑郁症患者血清自身抗体谱抗体表达常见，与抑郁症的进展有一定关系，但未见其与预后的关系。
Abstract:
Objective To explore the expression profiles of serum autoantibodies in patients with depression and their correlation with prognosis. Methods A total of 3 503 patients with depression diagnosed and treated at the Brain Hospital Affiliated to Nan-jing Medical University from July 2018 to March 2024 were enrolled. Serum autoantibody profiles were detected using Western blotting, and clinical data were collected. 115 patients with complete data and positive serum autoantibody profiles were assigned to the observation group, while 86 patients with negative serum autoantibody profiles during the same period were assigned to the control group. The therapeutic efficacy was assessed by the reduction rate of the Hamilton Depression Scale-24 (HAMD-24) score. Spearman correlation analysis was performed to evaluate the relationship between HAMD-24 scores and autoantibody profiles. Logistic regression analysis was used to identify prognostic factors for patients with depression. Results The positive rate of serum autoantibodies in patients with depression was 4.80% (168 / 3 503), with anti-SSA antibodies (SSA52 and SSA60) showing the highest positivity rate of 4.00% (140 / 3 503). Compared with the control group, the blood glucose （GLU）level in the observation group was significantly lower (4.85 ± 0.87 mmol/L vs 5.06 ± 0.78 mmol/L), with a statistically significant difference (t=2.900, P<0.01). Differences in other clinical indicators, pre-and post-treatment HAMD-24 total scores, and suicide risk scores were not statistically significant (t/Z=0.100～2.900, all P >0.05). The positive rate of serum anti-cyclic citrullinated peptide antibody (an-ti-CCP) in patients with mild (31.82%) and severe (32.14%) depression was higher than that in patients with moderate depression (8.11%), with significant differences (χ2=5.510, 7.362, all P< 0.05). Spearman analysis revealed that the HAMD-24 total scores at admission was negatively correlated with the expression of serum anti-Jo-1 antibody (r= -0.15, P < 0.05), while the total HAMD-24 score after 4 weeks of treatment was positively correlated with the expression of serum anti-SSA52 antibody (r = 0.14, P < 0.05). Multivariate analysis indicated that the blood glucose was an independent prognostic factor for depression patients with positive autoantibody profiles. Conclusions The expression of serum autoantibody profiles is common among patients with depression and is associated with the progression of depression, but no relationship with prognosis has been found.

参考文献/References:

[1] KALIN N H. New insights into major depression and the treatment of bipolar depression[J]. the American Journal of Psychiatry, 2021, 178(12): 1071-1074.
[2] 汪艳丽,韩彩莉,李卫,等.甲状腺功能相关基因多态性与抑郁障碍及抗抑郁治疗疗效的相关性研究[J].现代检验医学杂志, 2023, 38(4):8-15, 58. WANG Y L, HAN C L, LI W, et al. Association study of polymorphisms of thyroid function-related genes with depression and antidepressant efficacy[J]. Journal of Modern Laboratory Medicine, 2023, 38(4): 8-15, 58.
[3] MONROE S M, HARKNESS K L. Major depression and its recurrences: life course matters [J]. Annual Review of Clinical Psychology, 2022, 18: 329-357.
[4] BRISCH R, WOJTYLAK S, SANIOTIS A, et al. The role of microglia in neuropsychiatric disorders and suicide[J]. European Archives of Psychiatry and Clinical Neuroscience, 2022, 272(6): 929-945.
[5] BEUREL E, TOUPS M, NEMEROFF C B. The bidirectional relationship of depression and inflammation: double trouble[J]. NEURON, 2020, 107(2): 234-256.
[6] OSIMO E F, BAXTER L J, LEWIS G, et al. Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels[J]. Psychological Medicine, 2019, 49(12): 1958-1970.
[7] 袁瑞雪,傅迎美,禹顺英.辅助性T细胞17和调节性T细胞在抑郁症中的作用机制研究进展[J].上海交通大学学报(医学版), 2021, 41(10):1384-1388. YUAN R X, FU Y M, YU S Y. Research progress in the mechanism of helper T cell 17 and regulatory T cell in depression[J]. Journal of Shanghai Jiaotong University:Medical Science, 2021, 41(10): 1384-1388.
[8] KATZAV A, BEN-ZIV T, BLANK M, et al. Antibody-specific behavioral effects: intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice [J]. Journal of Neuroimmunology, 2014, 272(1/2): 10-15.
[9] 中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188. Chinese Society of Psychiatry. Chinese classification of mental disorders, third edition: classification of mental disorders[J]. Chinese Journal of Psychiatry, 2001, 34(3): 184-188.
[10] 郑莉明,史亚飞,吴皓萌,等.中枢5-HT能系统在早发性抑郁中的作用研究[J].中国药理学通报, 2015, 31(1): 19-22, 23. ZHENG L M, SHI Y F, WU H M, et al. Research on effect of central 5-HTergic system in early-onset depression[J]. Chinese Pharmacological Bulletin, 2015, 31(1): 19-22, 23.
[11] 李文波,许明智,贾福军,等.汉密顿抑郁量表6项版本的临床应用[J].中国神经精神疾病杂志, 2007, 33(2): 119-120. LI W B, XU M Z, JIA F J, et al. Clinical application of the 6-item version of the Hamilton depression scale[J]. Chinese Journal of Nervous and Mental Diseases, 2007, 33(2): 119-120.
[12] MCCARRON R M, SHAPIRO B, RAWLES J, et al. Depression [J]. Annals of Internal Medicine, 2021, 174(5): itc65-itc80.
[13] MAINA J G, BALKHIYAROVA Z, NOUWEN A, et al. Bidirectional mendelian randomization and multiphenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes [J]. Diabetes Care, 2023, 46(9): 1707-1714.
[14] CHING K H, BURBELO P D, CARLSON P J, et al. High levels of anti-GAD65 and anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance[J]. Journal of Neuroimmunology, 2010, 222(1/2): 87-89.
[15] JIA Y, LUAN S, HUANG S, et al. Prevalence and clinical significance of anti-SSA antibody in the Chinese health screening population[J]. Clinical and Experimental Immunology, 2024, 218(2): 169-176.
[16] DEFENDENTI C, ATZENI F, SPINA M F, et al. Clinical and laboratory aspects of Ro/SSA-52 autoantibodies[J]. Autoimmunity Reviews, 2011, 10(3):150-154.
[17] 唐亚梅,周利君,刘勇,等.抑郁症患者血清CRP?CER?Hcy和anti-CCP抗体的浓度变化[J].实用预防医学, 2012, 19(9): 1399-1401. TANG Y M, ZHOU L J, LIU Y, et al. Changes of serum CRP, CER, Hcy and anti-CCP concentrations in patients with depression[J]. Practical Preventive Medicine, 2012, 19(9): 1399-1401.
[18] ZHOU J L, DAI Y, LIN Y, et al. Association between serum amyloid A and rheumatoid arthritis: a systematic review and meta-analysis [J]. Seminars in Arthritis and Rheumatism, 2022, 52: 151943.
[19] OGAWA-MOMOHARA M, MURO Y. Myositis-specific and myositis-associated autoantibodies: their clinical characteristics and potential pathogenic roles [J]. Immunological Medicine, 2025,48(2):104-116.
[20] LI G C, YU Y F, LIN C Q, et al. Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic biomarkers: an analysis of the UK Biobank cohort [J]. eClinical Medicine, 2025, 79:102982.
[21] 丁砚秋,袁惠民,陈潇,等.抑郁症的现代医学研究与治疗进展[J].西部医学,2024,36(4):614-618. DING Y Q, YUAN H M, CHEN X, et al. Progress in modern medical treatment of depression[J]. Medical Journal of West China, 2024, 36(4): 614-618.
[22] MORIARTY A S, MEADER N, SNELL K I E, et al. Predicting relapse or recurrence of depression:systematic review of prognostic models[J]. British Journal of Psychiatry, 2022, 221(2): 448-458.
[23] 苑杰,李心桐,刘颖,等.抗抑郁药物起效时间的研究进展[J].神经疾病与精神卫生,2020,20(8):561-566. YUAN J, LI X T, LIU Y, et al. Research progress of onset time of antidepressants[J]. Journal of Neuroscience and Mental Health, 2020, 20(8): 561-566.

相似文献/References:

[1]游青青,杨海健,杨宇,等.抑郁症患者血清脂质及CK,LDH水平与疾病程度的相关性分析[J].现代检验医学杂志,2019,34(01):79.[doi:10.3969/j.issn.1671-7414.2019.01.020]
　YOU Qing-qing,YANG Hai-jian,YANG Yu,et al.Correlation Analysis of Serum Lipids，CK，LDH and Course of Disease in Patients with Depression[J].Journal of Modern Laboratory Medicine,2019,34(03):79.[doi:10.3969/j.issn.1671-7414.2019.01.020]
[2]肖广智,高 旋,丁 进.血清补体C3, C4 水平正常的活动性狼疮性肾炎患者的临床特征与实验室相关指标分析[J].现代检验医学杂志,2022,37(05):39.[doi:10.3969/j.issn.1671-7414.2022.05.009]
　XIAO Guang-zhi,GAO Xuan,DING Jin.Analysis of Clinical and Laboratory Characteristics of the Patients of Active Lupus Nephritis with Normal Levels of Serum Complement C3 and C4[J].Journal of Modern Laboratory Medicine,2022,37(03):39.[doi:10.3969/j.issn.1671-7414.2022.05.009]
[3]汪艳丽,韩彩莉,李 卫,等.甲状腺功能相关基因多态性与抑郁障碍及抗抑郁治疗疗效的相关性研究[J].现代检验医学杂志,2023,38(04):8.[doi:10.3969/j.issn.1671-7414.2023.04.002]
　WANG Yanli,HAN Caili,LI Wei,et al.Association Study of Polymorphisms of Thyroid Function-related Genes with Depression and Antidepressant Efficacy[J].Journal of Modern Laboratory Medicine,2023,38(03):8.[doi:10.3969/j.issn.1671-7414.2023.04.002]
[4]冉 涛,潘 锋,王永红,等.系统性红斑狼疮患者血清sMICA，sMICB 水平与自身抗体表达及疾病活动度的相关性研究[J].现代检验医学杂志,2024,39(04):100.[doi:10.3969/j.issn.1671-7414.2024.04.018]
　RAN Tao,PAN Feng,WANG Yonghong,et al.Correlation among Serum sMICA, sMICB Levels, Autoantibody Expression and Disease Activity in Patients with Systemic Lupus Erythematosus[J].Journal of Modern Laboratory Medicine,2024,39(03):100.[doi:10.3969/j.issn.1671-7414.2024.04.018]

备注/Memo

备注/Memo:
作者简介：李燕（1978-），女，本科，主管技师，主要从事临床免疫检验，E-mail：1075673245@qq.com。
通讯作者：陈晨（1985-），女，本科，主管技师，主要从事生化检验，E-mail：1270243902@qq.com。
更新日期/Last Update: 2026-05-15