[1]孙 娜,张文静,高 飞,等.β2GPⅠ及其抗体与抗磷脂综合征的研究进展[J].现代检验医学杂志,2015,30(01):19-22.[doi:10.3969/j.issn.1671-7414.2015.01.006]
 SUN Na,ZHANG Wen-jing,GAO Fei,et al.Research Progress of β2 GlycoproteinⅠ and Anti-β2GPⅠ Antibodies and Antiphospholipid Syndrome[J].Journal of Modern Laboratory Medicine,2015,30(01):19-22.[doi:10.3969/j.issn.1671-7414.2015.01.006]
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β2GPⅠ及其抗体与抗磷脂综合征的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
19-22
栏目:
综述
出版日期:
2015-01-30

文章信息/Info

Title:
Research Progress of β2 GlycoproteinⅠ and Anti-β2GPⅠ Antibodies and Antiphospholipid Syndrome
文章编号:
1671-7414(2015)01-019-04
作者:
孙 娜张文静高 飞刘彦虹
哈尔滨医科大学附属第二医院检验科,哈尔滨 150086
Author(s):
SUN NaZHANG Wen-jingGAO FeiLIU Yan-hong
Department of Clinical Laboratory, the Sencond Affiliated Hospital for Harbin Medical University,Harbin 150086,China
关键词:
β2糖蛋白Ⅰ 抗β2GPⅠ抗体 抗磷脂综合征
分类号:
R392.11
DOI:
10.3969/j.issn.1671-7414.2015.01.006
文献标志码:
A
摘要:
抗磷脂综合征(APS)是一种以血栓形成和(或)习惯性流产为临床特征的自身免疫性疾病。β2糖蛋白Ⅰ(β2GPⅠ)是该病的主要抗原,抗β2GPⅠ抗体是以β2GPⅠ为靶抗原的自身抗体。研究表明,β2GPⅠ及其自身抗体在APS血栓形成的致病过程中起到重要作用。目前APS的诊断与治疗也越来越受到人们的重视,检测抗β2GPⅠDⅠ抗体能特异性诊断APS,分子水平的研究也成为治疗APS的新方向。该文就β2GPⅠ、抗β2GPⅠ抗体与APS的相关性进展作以综述。
Abstract:
Antiphospholipid syndrome(APS)is an autoimmunemultisystem disorder characterized clinically by recurrent thrombosis and pregnancy morbidity.β2-glycoproteinⅠ(β2GPⅠ)is the major antigen in the APS.Anti-β2GPⅠ antibody is the autoantibody which targets to β2GPⅠ.There is overwhelming evidence that β2GPⅠand anti-β2GPⅠ antibody play an important rolein the pathogenesis of APS.Now the diagnosis and treatment of anti-β2GPⅠ antibody are more and more get people's attention,detection of anti-β2GPⅠDⅠ antibody can specifically diagnose APS and research of the molecular level may provide a new therapeutic target for APS.In this paper,β2GPⅠ,anti-β2GPⅠ antibody and APS associated development were reviewed.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(编号:81270394)。
作者简介:孙 娜(1988-),女,在读硕士,E-mail:765235815@qq.com。
通讯作者:刘彦虹(1964-),女,博士,教授,博士生导师,主要从事自身免疫病学研究。
更新日期/Last Update: 2015-01-30