[1]韩 放,胡晓芳,孟冬娅,等.系统性硬化病患者血浆D-dimer的临床意义探讨[J].现代检验医学杂志,2015,30(01):132-133.[doi:10.3969/j.issn.1671-7414.2015.01.039]
　HAN Fang,HU Xiao-fang,MENG Dong-ya,et al.Clinical Significance of Plasma D-dimer in Systemic Sclerosis[J].Journal of Modern Laboratory Medicine,2015,30(01):132-133.[doi:10.3969/j.issn.1671-7414.2015.01.039]
点击复制

系统性硬化病患者血浆D-dimer的临床意义探讨()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
132-133
栏目:
检验与临床
出版日期:
2015-01-30

文章信息/Info

Title:
Clinical Significance of Plasma D-dimer in Systemic Sclerosis
文章编号:
1671-7414(2015)01-132-03
作者:
韩 放1; 胡晓芳2; 孟冬娅2; 郑 伟2; 王 璐2; 万 楠2
1.大连市第二人民医院检验科,辽宁大连 116011;
2.沈阳军区总医院检验科,沈阳 110016
Author(s):
HAN Fang1; HU Xiao-fang2; MENG Dong-ya2; ZHENGWei2; WANG Lu2; WAN Nan2
1.Department of Clinical Laboratory,Dalian Second People's Hospital, Liaoning Dalian 116011,China;
2.Department of Clinical Laboratory, General Hospital of Shenyang Military Area Command,Shenyang 110016,China
关键词:
系统性硬化;  D-二聚体;  肺动脉高压
分类号:
R593.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.01.039
文献标志码:
A
摘要:
目的 探讨系统性硬化病(systemic sclerosis,SSc)与血浆D-dimer浓度的相关性以及纤溶系统在SSc中可能发挥的致病作用机制。方法收集2013年1月～2014年1月沈阳军区总医院内分泌科SSc患者32名和35名健康体检人群,检测血浆D-dimer浓度,采用t检验和logistic回归分析其与对照组、肺动脉高压的相关性。结果 健康组血浆D-dimer浓度为0.28±0.04 μg/ml,SSc患者为0.31±0.05 μg/ml,明显高于对照组,差异有统计学意义(t=1.997,P=0.008); 而在不同类型的SSc患者中,与限制性患者D-dimer浓度(0.30±0.03 μg/ml)相比,弥漫性患者(0.41±0.06 μg/ml)明显升高,差异有统计学意义(t=2.051,P<0.001); logistic回归分析发现,随着血浆D-dimer浓度的增高,病人发生轻度肺动脉高压的风险也升高,OR=4.38,95%置信区间为2.59～8.91,P=0.008。结论 SSc患者体内升高的血浆D-dimer浓度反映了机体潜在的血栓纤溶系统激活,它有可能最终导致病人发生肺动脉高压与血栓性并发症。
Abstract:
Objective To study correlation between systemicsclerosis(SSc)and plasma D-dimer and to reveal the probably rules of the fibrinolytic systems in SSc.Methods In 2013 January to 2014January,cellected 32 patients with SSc and 35 with healthy controls to detectedlevel of plasma D-dimer.Logistic and t student test were used for statistical analysis for correlation between SSc and pulmonary artery hypertension.Results When compared to healthy controls(0.28±0.04 μg/ml),the level of plasma D-dimer were significantly increased in SSc patient(0.31±0.05 μg/ml,t=1.997,P=0.008).After stratifying SSc patients according to disease subset,whereas patients with diffuse subset displayed substantially increased values(0.41±0.06 μg/ml,t=2.051,P<0.001).The level of plasma D-dimer was associated with pulmonary artery hypertension(OR=4.38,95%CI=2.59～8.91,P=0.008).Conclusion Demonstrated that SSc patients with diffuse subset are characterized by increased plasma D-dimer values,reflecting a potential activation of fibrinolytic cascaded,which might finally predispose these patients to thrombotic complications andpulmonary artery hypertension.

参考文献/References:

[1] Kahaleh MB.Vascular involvement in systemic sclerosis(SSc)[J].Clin Exp Rheumatol,2004,22(3 Suppl 33):S19-23.
[2] Ames PR,Lupoli S,Alves J,et al.The coagulation/fibrinolysis balance in systemic sclerosis:evidence for a haematological stress syndrome[J].Br J Rheumatol,1997,36(10):1045-1050.
[3] Cerinic MM,Valentini G,Sorano GG,et al.Blood coagulation,fibrinolysis,and markers of endothelial dysfunction in systemic sclerosis[J].Semin Arthritis Rheum,2003,32(5):285-295.
[4] Maeda M,Kachi H,Mori S.Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis(PSS)[J].J Dermatol Sci,1996,11(3):223-227.
[5] Prisco D,Antonucci E,Marcucci R,et al.D-dimer in the year 2000:current data and new perspectives[J].Ann Ital Med Int,2000,15(4):267-272.
[6] Subcommittee for scleroderma criteria of the American rheumatism association diagnostic and therapeutic criteria committee.Preliminary criteria for theclassification of sclerosis(scleroderma)[J].Arthritis Rheum,1980,23(5):581-590.
[7] Arkel YS,Paidas MJ,Ku DH.The use of coagulation activation markers(soluble fibrin polymer,TpP,prothrombin fragment 1.2,thrombin-antithrombin,andD-dimer)in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders[J].Blood Coagul Fibrinolysis,2002,13(3):199-205.
[8] Stegnar M,Vene N,Bozic M.Do haemostasis activation markers that predict cardiovascular disease exist?[J].Pathophysiol Haemost Thromb,2003,33(5/6):302-308.
[9] Halevy D,Radhakrishnan J,Markowitz G,et al.Th-rombotic microangiopathies[J].Crit Care Clin,2002,18(2):309-320,vi.

相似文献/References:

[1]何晓璇a,王 刚a,郭 炫a,等.FIB,DD和FDP在高血压肾损伤中的变化及临床意义[J].现代检验医学杂志,2016,31(02):73.[doi:10.3969/j.issn.1671-7414.2016.02.022]
　HE Xiao-xuana,WANG Ganga,GUO Xuana,et al.Changes and Clinical Significance Observation on FIB, DD and FDP in Renal Impairment of Hypertension[J].Journal of Modern Laboratory Medicine,2016,31(01):73.[doi:10.3969/j.issn.1671-7414.2016.02.022]
[2]朱 晶,翟海军.血清CEA,Ferritin和血浆D-D对肺癌化疗的效果评估[J].现代检验医学杂志,2015,30(04):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
　ZHU Jing,ZHAI Hai-jun.Evaluation on the Effect of Serum CEA,Ferritin and Plasma D-D on Lung Cancer Chemotherapy[J].Journal of Modern Laboratory Medicine,2015,30(01):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
[3]刁 雪,彭兰欢,曾婷婷,等.血细胞计数和D-二聚体检测 在肺癌并发血栓患者中的变化研究[J].现代检验医学杂志,2015,30(01):68.[doi:10.3969/j.issn.1671-7414.2015.01.018]
　DIAO Xue,PENG Lan-huan,ZENG Ting-ting,et al.Analysis of the Changes of Blood Cell Count and D-dimer in Lung Cancer Patients with Thrombosis[J].Journal of Modern Laboratory Medicine,2015,30(01):68.[doi:10.3969/j.issn.1671-7414.2015.01.018]
[4]阿地拉·阿布里孜,古兰木拜尔·安尼瓦尔.心功能不全透析患者检测纤维蛋白单体的临床意义[J].现代检验医学杂志,2016,31(04):149.[doi:10.3969/j.issn.1671-7414.2016.04.043]
　ADILA·Abulizi,GULANMUBAIER·Anniwaner.Clinical Significance of Detection Fibrin Monomer in Hemodia Lysis with Cardiac Insufficiency Patients[J].Journal of Modern Laboratory Medicine,2016,31(01):149.[doi:10.3969/j.issn.1671-7414.2016.04.043]
[5]杨 阳,吴 嘉,汪俊军.FIB和D-二聚体联合GRACE评分与急性冠脉综合征的风险预测[J].现代检验医学杂志,2017,32(01):99.[doi:10.3969/j.issn.1671-7414.2017.01.027]
　YANG Yang,WU jia,WANG Jun-jun.FIB and D-D with GRACE Risk Score to Predict the Risk of Acute Coronary Syndrome[J].Journal of Modern Laboratory Medicine,2017,32(01):99.[doi:10.3969/j.issn.1671-7414.2017.01.027]
[6]何凤娥,刘依霜,段春艳.ACI患者TEG各项参数与PAgT和D-二聚体之间的相关性[J].现代检验医学杂志,2017,32(01):134.[doi:10.3969/j.issn.1671-7414.2017.01.037]
　HE Feng-e,LIU Yi-shuang,DUAN Chun-yan.Correlation between TEG Parameters and PAgT and D-Dimer in Patients with ACIH[J].Journal of Modern Laboratory Medicine,2017,32(01):134.[doi:10.3969/j.issn.1671-7414.2017.01.037]
[7]李 虎.血浆纤维蛋白单体水平检测对下肢骨折术后静脉栓塞的预测价值[J].现代检验医学杂志,2017,32(05):133.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　LI Hu.Predictive Value of Plasma Fibrin Monomer Level on Postoperative Venous Thromboembolism in Fracture of Lower Limb[J].Journal of Modern Laboratory Medicine,2017,32(01):133.[doi:10.3969/j.issn.1671-7414.2017.05.017]
[8]方美华,陈丽珠,冯建捷.子宫颈癌、子宫癌和卵巢癌患者血浆D-二聚体检测的临床意义[J].现代检验医学杂志,2017,32(05):145.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　FANG Mei-hua,CHEN Li-zhu,FENG Jian-jie.Clinical Significance of Plasma D-Dimer Detection in Cervical Cancer,Uterine Cancer and Ovarian Cancer[J].Journal of Modern Laboratory Medicine,2017,32(01):145.[doi:10.3969/j.issn.1671-7414.2017.05.017]
[9]张 华a,李小侠a,刘 婧a,等.胸腔积液中CEA,FDP和DD检测对良恶性胸腔积液鉴别的意义[J].现代检验医学杂志,2017,32(06):122.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　ZHANG Huaa,LI Xiao-xiaa,LIU Jinga,et al.Diagnosis Value of CEA,FDP and DD in the Pleural Effusion Specimens for Benign and Malignant Pleural Effusion[J].Journal of Modern Laboratory Medicine,2017,32(01):122.[doi:10.3969/j.issn.1671-7414.2017.06.001]
[10]吴剑锋.复发性自然流产患者血浆D-二聚体、抗凝血酶Ⅲ和蛋白C检测的临床意义[J].现代检验医学杂志,2018,33(04):112.[doi:10.3969/j.issn.1671-7414.2018.04.030]
　WU Jian-feng.Detection and Analysis of D-Dimer,Antithrombin Ⅲ and Protein C in Patients with Recurrent Spontaneous Abortion[J].Journal of Modern Laboratory Medicine,2018,33(01):112.[doi:10.3969/j.issn.1671-7414.2018.04.030]

备注/Memo

备注/Memo:

作者简介:韩 放(1971-),女,硕士学位,副主任技师,研究方向:免疫学检验工作,Tel:13940926897,E-mail:syplay@me.com。
通讯作者:万 楠(1978-),男,硕士学位,副主任技师,研究方向:心血管疾病发病风险分析,Tel:13352452082,E-mail:wannan@ymail.com。
更新日期/Last Update: 2015-01-30