[1]崔婵娟,张 捷,乔 蕊.破碎红细胞检测研究进展[J].现代检验医学杂志,2016,31(02):1-4.[doi:10.3969/j.issn.1671-7414.2016.02.001]
　CUI Chan-juan,ZHANG Jie,QIAO Rui.Research Progress in the Detection of Schistocytes[J].Journal of Modern Laboratory Medicine,2016,31(02):1-4.[doi:10.3969/j.issn.1671-7414.2016.02.001]
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破碎红细胞检测研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
1-4
栏目:
述评
出版日期:
2016-06-01

文章信息/Info

Title:
Research Progress in the Detection of Schistocytes
作者:
崔婵娟; 张 捷; 乔 蕊
北京大学第三医院检验科,北京 100191
Author(s):
CUI Chan-juan; ZHANG Jie; QIAO Rui
Department of Laboratory Medicine, the Third Hospital of Peking University,Beijing 100191,China
关键词:
破碎红细胞;  血栓性微血管病;  光学显微镜;  自动检测仪
分类号:
R446.113
DOI:
10.3969/j.issn.1671-7414.2016.02.001
文献标志码:
A
摘要:
红细胞在血液循环中受到外在机械损伤而产生的破碎红细胞是诊断血栓性微血管病(thrombotic microangiopathy,TMA)的重要形态学线索。TMA代表性疾病有血栓性血小板减少性紫癜(Thrombocytopenic purpura,TTP)、溶血尿毒症综合征(hemolytic uremic syndrome,HUS)等,尤其是近年来,人们对移植相关血栓性微血管病的研究不断深入,外周血破碎红细胞检测越来越受到关注。但是关于破碎红细胞形态学诊断标准及破碎红细胞诊断TMA阈值等问题,由于工作人员个人经验、检测方法及疾病种类等差异,目前各实验室还没有一个完全统一的标准。并且随着近年来自动血细胞分析仪检测外周血破碎红细胞技术的发展,关于该技术检测方法的统一性、临床实用性及可靠性等问题也越来越受到人们的关注。该文将从手工检测方法及自动血细胞分析仪检测方法对目前临床上外周血破碎红细胞的检测进行总结。
Abstract:
Within the circulation,schistocytes are produced by extrinsic mechanical damage.Schistocyte is an important morphological clueto the diagnosis of thrombotic microangiopathy(TMA).The presence of schistocyte in the blood indicates the possibility of a thrombotic microangiopathy,in particular,the two major syndromes of thrombocytopenic purpura(TTP)and hemolytic uremic syndrome(HUS).In addition,with the increased study of hematopoieticstem cell transplantation associated thrombotic microangiopathy,the detection of schistocytes has been paid more and more attention.Because of the differencesof observers,methods and diseases,there are no full consensus criteria aboutthe morphological of schistocytes and threshold value for the diagnosis of TMA.Recently,with the development of automated red blood cells(RBCs)fragment count,the reliability and clinical utility of automated schistocytes count has alsobeen paid attention by more and more people.They will summary the detection ofschistocytes from the two aspects of manual microscopy and automated RBCs fragment count.

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备注/Memo

备注/Memo:
基金项目:首都临床特色应用研究(Z141107006614003),国家自然科学基金(81550041)。 作者简介:崔婵娟(1986-),女,研究生,研究方向:临床检验诊断学,E-mail:chanjuancui@126.com。 通讯作者:乔 蕊,Tel:010-82265751。
更新日期/Last Update: 2016-02-20