[1]赵 枰,段义农,张秀琳.口腔与胃内幽门螺杆菌感染的相关性[J].现代检验医学杂志,2016,31(02):112-114.[doi:10.3969/j.issn.1671-7414.2016.02.033]
　ZHAO Ping,DUAN Yi-nong,ZHANG Xiu-lin.Study on the Association between Helicobacter Pylori Infection in Oral Cavity and Gastric Helicobacter Pylori Infection[J].Journal of Modern Laboratory Medicine,2016,31(02):112-114.[doi:10.3969/j.issn.1671-7414.2016.02.033]
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口腔与胃内幽门螺杆菌感染的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
112-114
栏目:
检验与临床
出版日期:
2016-06-01

文章信息/Info

Title:
Study on the Association between Helicobacter Pylori Infection in Oral Cavity and Gastric Helicobacter Pylori Infection
作者:
赵 枰1; 段义农2; 张秀琳1
1.南通市第一人民医院,江苏南通 226001; 2.南通大学,江苏南通226001
Author(s):
ZHAO Ping1; DUAN Yi-nong2; ZHANG Xiu-lin1
1.the First People's Hospital of Nantong,Jiangsu Nantong 226001,China; 2.Nantong University,Jiangsu Nantong 226001,China
关键词:
幽门螺杆菌;  幽门螺杆菌唾液测试板;  碳-13尿素呼气试验
分类号:
R378.2
DOI:
10.3969/j.issn.1671-7414.2016.02.033
文献标志码:
A
摘要:
目的 探讨口腔幽门螺杆菌(Hp)感染与胃Hp感染的相关性,及口腔Hp感染对Hp根除治疗的影响。方法 选择216例上消化道不适患者,均给予幽门螺杆菌唾液测试板(HPS),13C-UBT检测,以13C-UBT为金标准,对HPS法检测结果用贝叶斯定理方法进行评价。选择13C-UBT阳性患者168例,经PPI三联或四联7天疗法规范的抗Hp治疗后4周和3个月,复查13C-UBT,并对两者结果进行对比研究。结果 ①利用贝叶斯定理计算得出:在口腔感染Hp发生的条件下胃感染Hp发生的概率为84.1%。HPS的灵敏度为66.1%,特异度为56.3%,阳性预测值为84.1%,阴性预测值为32.1%。②216例上消化道不适患者中,HPS阳性率为61.1%,13C-UBT阳性率为77.8%,两种检测方法比较,差异有统计学意义(χ2=14.138,P<0.01).13C-UBT阳性者,HPS阳性率为66.1%; 13C-UBT阴性者,HPS阳性率为43.8%,两者比较差异有统计学意义(χ2=7.827,P<0.01)。③治疗后4周,HPS阳性者(n=75),胃Hp根除率为93.3%; HPS阴性者(n=27),胃Hp根除率为92.6%,两者比较差异无统计学意义(χ2=0.000,P>0.05).3个月后,HPS阴性者(n=42)胃Hp根除率(63.2%),明显高于HPS阳性者(n=19)(33.3%),两者比较差异有统计学意义(χ2=4.758,P<0.05))。结论 口腔Hp感染与胃内Hp感染密切相关,胃Hp的感染复发率受口腔Hp存在的影响。
Abstract:
Objective To explore association between Helicobacter pylori(Hp)infection in oral cavity and gastric Hp infection,and also to study the effect of Hp infection in oral cavity on Hp eradication treatment.Methods A total of 216 patients with dyspepsia went through HPS and 13C-UBT examination.As gold standards of 13C-UBT,a comparison study with HPS was evaluated using Bayes formula.168 patients had the positive result of 13C-UBT who were treated by triple or quadrupletherapy of PPI for 7 days.13C-UBT was taken 4 weeks and 3 months laterafter the treatment finished.And the results detected by the two methods abovewere compared.Results ①Calculated using bayes' theorem:under the condition of oral helicobacter pylori infection incidence of gastrichelicobacter pylori infection was 84.1%.The sensitivity,specificity,positive and negative predictive value of HPS was 66.1%,56.3%,84.1%and 32.1%respectively.②In the 216 patients with dyspepsia.The positive rate of HPS was61.1%.The difference was statistically significant while it was compared tothe rate of 13C-UBT(77.8%)(χ2=14.138,P<0.01).The positiverate of HPS was 66.1% among 13C-UBT positive,and was 43.8% in patient with 13C-UBT negative,the difference was statistically significant(χ2=7.827,P<0.01).③ 4 weeks after the treatment finished,the eradiation rate in HPS positive cases(n=75)was 93.3%,and negative cases was 92.6%(n=27)and the difference was not statistically significant(χ2=0.000,P>0.05).3 months later,the eradiation rate in HPS negative caseswas 63.2%,which was obviously higher than that in HPS positive cases(33.3%),the difference was statistically significant(χ2=4.758,P<0.05)).Conclution The Hp infection in oral cavity might be closelyrelevant to the infection in stomach.The existence of oral Hp might be the cause of recurrent gastric Hp infection.

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备注/Memo

备注/Memo:
作者简介:赵 枰(1977-),大学本科,副主任技师,主要从事免疫学检验,Tel:13773604080,E-mail:zhaopinghonghong@163.com。 通讯作者:张秀琳,E-mail:nantongyyzxl@163.com。
更新日期/Last Update: 2016-02-20