[1]王一多,金英玉,关秀茹.肾脏水通道蛋白-1(AQP-1)的研究进展[J].现代检验医学杂志,2016,31(03):162-164.[doi:10.3969/j.issn.1671-7414.2016.03.046]
 WANG Yi-duo,JIN Ying-yu,GUAN Xiu-ru.Progress in the Research of Aquaporin-1(AQP-1)of the Kidney[J].Journal of Modern Laboratory Medicine,2016,31(03):162-164.[doi:10.3969/j.issn.1671-7414.2016.03.046]
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肾脏水通道蛋白-1(AQP-1)的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年03期
页码:
162-164
栏目:
综述
出版日期:
2016-06-15

文章信息/Info

Title:
Progress in the Research of Aquaporin-1(AQP-1)of the Kidney
作者:
王一多金英玉关秀茹
哈尔滨医科大学附属第一医院检验科,哈尔滨 150000
Author(s):
WANG Yi-duoJIN Ying-yuGUAN Xiu-ru
Department of Clinical Laboratory, the First Affiliated Hospital of Harbin Medical University,Harbin 150000,China
关键词:
水通道蛋白(AQP) 肾脏疾病
分类号:
R692; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.03.046
文献标志码:
A
摘要:
水通道蛋白(AQP)是一种分子量约28 kD的四聚体结构膜通道蛋白。哺乳动物中有13种不同的AQP,表达于不同的组织器官,调节水以及甘油和尿素等小分子跨膜转运。AQP-1主要表达于肾近曲小管和髓袢降支细段上皮细胞顶膜和基底膜,负责肾小管水分子的重吸收。当肾脏发生病变或者损伤时,AQP-1的表达也会随之改变,所以研究AQP-1对于了解水代谢疾病的发生机制以及指导临床水代谢疾病的治疗具有十分重要的意义。
Abstract:
Aquaporin(AQP)is a molecular weight of about 28 kD of the four polymer structure membrane channel protein.In mammals,there are 13 different AQP,expressed in different tissues and organs,regulating waterand glycerol and urea and other small molecules transmembrane transport of majorproteins.AQP-1 is mainly expressed in the renal proximal tubule and Henle'sloop drop bronchiole epithelial cell apical membrane and basement membrane,is responsible for the reabsorption of renal tubular water molecules.The expressionof AQP-1 can be changed when the kidney is damaged or damaged,so it is very important to study the mechanism of AQP-1 for understanding the pathogenesis ofwater metabolism and the treatment of clinical water metabolism.

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备注/Memo

备注/Memo:
基金项目:国家自然基金青年项目(编号:81501825),DIC肾损伤时肾小管上皮细胞AQP1和AQP2蛋白表达的调控机制研究。 作者简介:王一多(1990-),男,在读硕士,主要从事临床免疫学检验研究,Tel:15045016635,E-mail:wangyiduo0309@163.com。 通讯作者:关秀茹,E-mail:guanxiuru0451@163.com。
更新日期/Last Update: 2016-06-25