[1]喻 晶,张文龙,卢丽华,等.深圳2 580例高危男性人乳头瘤状病毒基因型分析[J].现代检验医学杂志,2016,31(04):95-97.[doi:10.3969/j.issn.16717-414.2016.04.026]
　YU Jing,ZHANG Wen-long,LU Li-hua,et al.Analysis of Human Papillomavirus Genotype in 2 580 Men Residing in Shenzhen[J].Journal of Modern Laboratory Medicine,2016,31(04):95-97.[doi:10.3969/j.issn.16717-414.2016.04.026]
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深圳2 580例高危男性人乳头瘤状病毒基因型分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
95-97
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Analysis of Human Papillomavirus Genotype in 2 580 Men Residing in Shenzhen
文章编号:
1671-7414(2016)04-095-03
作者:
喻 晶; 张文龙; 卢丽华; 吴夏枫; 张银汉; 刘晓翌
北京大学深圳医院检验科,广东深圳 518036
Author(s):
YU Jing; ZHANG Wen-long; LU Li-hua; WU Xia-feng; ZHANG Yin-han; LIU Xiao-yi
Department of Laboratory Medicine, Shenzhen Hospital of Beijing University,Guangdong Shenzhen 518036,China
关键词:
人乳头瘤状病毒(HPV);  男性感染;  HPV基因分型;  深圳
分类号:
R373.9; Q786
DOI:
10.3969/j.issn.16717-414.2016.04.026
文献标志码:
A
摘要:
目的 探讨深圳门诊高危男性患者人乳头瘤状病毒(HPV)感染的分布状况及基因型特点,为男性HPV感染的干预提供理论依据。方法 采用多重PCR结合反向斑点膜杂交的基因芯片技术对2012年3月～2014年6月在北京大学深圳医院收集的2 580例门诊疑似HPV感染的高危男性患者的生殖道脱落细胞进行23种HPV基因分型检测。结果 2 580例样本中HPV阳性1 164例,阳性率为45.12%, 其中低危型、高危型及高低危混合型感染的阳性率分别为51.03%(594/1 164),24.74%(288/1 164),24.23%(282/1 164)。低危型以HPV6(46.29%),HPV11(25.31%),HPV43(18.77%)和HPV42(9.62%)为常见亚型; 高危型以HPV16(16.58%),HPV52(12.59%),HPV33(10.60%),HPV58(7.98%)和HPV56(7.73%)为常见亚型。HPV感染以单一型感染为主(63.23%),二重及多重感染分别为10.48%和26.29%。年龄分层结果显示,不同年龄组HPV阳性率差异无统计学意义(χ2=6.98,P>0.05)。结论 深圳市高危男性HPV感染率较高,HPV6,11,43,42为主要的低危亚型,HPV16,52,33,58,56为主要的高危亚型,感染以单一亚型为主。
Abstract:
Objective To assess the prevalence and genotypedistribution of human papillomavirus(HPV)infection among men residing in Shenzhen,and provide the convincing evidence for the HPV intervention in men.Methods By using multiple PCR with reverse dot-blot gene chiptechnique,the 23 kinds of HPV gene types were detected in 2 580 male out-patients,who were suspected with HPV infection in Shenzhen Hospital of Beijing University from March 2012 to June 2014.Results Among 2 580cases,1 164 male patents were HPV positive,and the overall HPV positive rate was 45.12%.The positive rates of low-risk,high-risk,both low and high riskHPV types were 51.03%(594/1 164),24.74%(288/1 164)and 24.23%(282/1 164),respectively.The most commonly detected low-risk genotypes were HPV6(46.29%),HPV11(25.31%)and HPV43(18.77%),respectively.The most frequently detected high-risk HPV genotypes were HPV16(16.58%),HPV52(12.59%),HPV33(10.60%),HPV58(7.98%)and HPV56(7.73%),respectively.HPV infection was dominated by a single type infection(63.23%),and the rates of double and multiple type infections were 10.48% and 26.29%,respectively.Age stratification showed that HPV positive rate in different age groups had no statistically difference(Chi-square value 6.98,P>0.05).Conclusion The HPVinfection rate of high-risk men in Shenzhen was high.HPV6,11,43,42 were themost commonly detected low-risk types; and HPV16,52,33,58,56 were the mostcommonly detected high-risk types.Most male patients were single type HPV infection.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介:喻 晶(1967-),女,医学硕士,主任技师,主要从事临床分子生物学研究,E-mail:jing yu2004@aliyun.com。
更新日期/Last Update: 2016-08-10