[1]许红霞,宋来春.血栓弹力图动态监测AIS患者瑞通立静脉溶栓过程及其应用[J].现代检验医学杂志,2016,31(05):137-139.[doi:10.3969/j.issn.1671-7414.2016.05.040]
　XU Hong-xia,SONG Lai-chun.Thromboelastographic Dynamic Monitoring and Clinical Application in Patients Experiencing Acute Ischemic Stroke and Receiving Reteplase[J].Journal of Modern Laboratory Medicine,2016,31(05):137-139.[doi:10.3969/j.issn.1671-7414.2016.05.040]
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血栓弹力图动态监测AIS患者瑞通立静脉溶栓过程及其应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
137-139
栏目:
检验与临床
出版日期:
2016-10-21

文章信息/Info

Title:
Thromboelastographic Dynamic Monitoring and Clinical Application in Patients Experiencing Acute Ischemic Stroke and Receiving Reteplase
文章编号:
1671-7414(2016)05-137-03
作者:
许红霞1; 2; 宋来春1; 2
1.聊城市第三人民医院检验科,山东聊城 252000;
2.聊城市心脑血管病诊治重点实验室,山东聊城 252000
Author(s):
XU Hong-xia1; 2; SONG Lai-chun1; 2
1.Department of Clinical Laboratory,the Third People's Hospital of Liaocheng, Shandong Liaocheng 252000,China;
2.Liaocheng's Key Laboratory of Diagnosis and Treatment of Cardio-cerebral Vascular Diseases,Shandong Liaocheng 252000,China
关键词:
急性缺血性脑卒中;  血栓弹力图;  瑞通立
分类号:
R743; R446.11
DOI:
10.3969/j.issn.1671-7414.2016.05.040
文献标志码:
A
摘要:
目的 探讨急性缺血性脑卒中(AIS)瑞通立静脉溶栓过程中血栓弹力图的变化。方法 选取2013年10月～2015年8月在聊城市第三人民医院住院的急性缺血性脑卒中患者43例,从发病到溶栓治疗时间在4.5 h内,并在溶栓前、溶栓后0.5 h、溶栓后1 h、溶栓后2 h 及溶栓后4 h,抽其静脉血测定血栓弹力图。结果 在瑞通立静脉溶栓过程中,血栓弹力图测定参数(R,K,Angle和MA)均发生了变化。溶栓后0.5 h R值较溶栓前增高,溶栓后1 h达最高; K值在溶栓后0.5 h升为最高; Angle角和MA值在溶栓后0.5 h达最低值; R值溶栓后1 h与溶栓前比较差异有统计学意义(P<0.001),K值,Angle角和MA值溶栓后0.5 h分别与溶栓前比较差异均有统计学意义(P<0.001)。结论 研究表明血栓弹力图是在瑞通立静脉溶栓过程中进行动态检测来判断凝血状态的有用工具。
Abstract:
Objective To observe the effect of reteplase onthe thromboelastogram tracing of patients experiencing acute ischemic stroke(AIS).Methods Selected 43 AIS inpatients in the Third People's Hospital of Liaocheng from October,2013 to August,2015,who received reteplase less than 4.5 hours after the onset of syndrome of AIS.Blood samples were obtained before reteplase administration and at 0.5,1,2 and 4 hours afterreteplase administration and measured by thromboelastography.ResultsThe parameters R,K,Angle and MA of the thromboelastogram had changed after beginning administration of reteplase.The R value at 0.5 h after thrombolysis was significantly higher than that before thrombliysis,however,the RValue at 1h after thrombolysis was the most highest,and the K value.At 0.5 hafter thrombolysis was the highest.At 0.5 h after thrombolysis MA and Angle values were the lowest,the differences were statistically significant(P<0.001).Conclusion The study suggests that the thromboelastogram is an useful tool for determining changes in the coagulation system of patients receiving reteplase.

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备注/Memo

备注/Memo:
基金项目:2014年度聊城市科技发展计划资助项目(2014GJH17)。
作者简介:许红霞(1981-),女,汉族,硕士,主管检验师,主要从事血栓与止血的研究,Tel:0635-8381428,13206350907,E-mail:xuhx0907@126.com。
更新日期/Last Update: 2016-10-30