[1]张 洁,寇 莹,马 丽,等.正常孕妇不同孕期甲状腺功能参考范围的分析研究[J].现代检验医学杂志,2017,32(03):144-145，148.[doi:10.3969/j.issn.1671-7414.2017.03.040]
　ZHANGJie,KOU Ying,MA Li,et al.Reserch on the Tlyroid Function Reference Range of Different Pregnancy Period of Normal Pregnant Women[J].Journal of Modern Laboratory Medicine,2017,32(03):144-145，148.[doi:10.3969/j.issn.1671-7414.2017.03.040]
点击复制

正常孕妇不同孕期甲状腺功能参考范围的分析研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
144-145，148
栏目:
检验与临床
出版日期:
2017-05-25

文章信息/Info

Title:
Reserch on the Tlyroid Function Reference Range of Different Pregnancy Period of Normal Pregnant Women
文章编号:
1671-74 14(2017)03-144-03
作者:
张 洁; 寇 莹; 马 丽; 刘少华; 张学敏; 陈正福
陕西省汉中市中航工业3201医院核医学科，陕西汉中 723000
Author(s):
ZHANG　Jie; KOU Ying; MA Li; LIU Shao-hua; ZHANG Xue- min; CHEN Zheng-fu
Department of Nuclear Medicine,Hanzhong AVIC 3201 Hospital，Shaanxi Hanzhong 723000，Chi na
关键词:
妊娠; 甲状腺激素; 正常参考范围
分类号:
R714.1；R446.6
DOI:
10.3969/j.issn.1671-7414.2017.03.040
文献标志码:
A
摘要:
目的 建立并探讨汉中地区正常孕妇不同孕期的甲状腺功能 测量结果正常参考值范围。方法 收集2012年7月～2015年12月汉 中地区常住妊娠妇女4　031例，按NACB纳入标准，采用随机、分层、整群抽样相结合的方法 ，使 用全自动化学发光分析仪及其配套试剂进行甲状腺激素水平检测，并据不同孕期分为：早孕 (T1)998例，中孕(T2)1　543，晚孕(T3)1　490例，同时选取年龄相仿的未妊娠育龄期妇女( T0)105例作为对照组。结果 ①妊娠三期甲状腺激素水平不同，TSH 于早、中、晚三期分别为0.25 ～5.32，0.42～6.26和0.61～7.68 mIU/L；FT3分别 为3.54～6.04，3.57～5.94和2.93～5.40 pmol/L；FT4分别为7.11～16.88，6.7 8～16.94和6.03～16.87 pmol/L，妊娠期妇女的甲状腺激素水平与未孕妇女相比较，TSH (χ2=233.183，P<0.05)，FT4(χ2=388.12，P<0.05)，FT3(χ2=558 .795，P<0.05))。②TSH在孕早期相对于未孕妇女减低，孕中晚期相对增高；FT3和FT4 的变化是一致的，与非孕妇女相比均是减 低的，且随孕期延长下降越明显。结论 妊娠妇女甲状腺功能水平不 同于非孕妇女，需建立当地妊娠特异性甲状腺激素正常参考范围。
Abstract:
Objective To establish the reference range of t hyroid function from the normal pregnant women in different pregnant period in H anzhong region．Methods According to the NACB inclusion c riteria，collected local resident pregnant women 4 031 cases，from July 2012 to December 2015．With the combination of random sampling，stratified sampling and cluster sampling，thyroid hormone levels were measured by a fully automated ch emiluminescence analyzer and its accompanying reagents．All patients were divide d into three groups：998 cases in early pregnancy (T1)，1 543 cases in mid-preg nancy (T2)，1 490 cases in late pregnancy (T3)，and 105 cases of non-pregnant w omen in childbearing age (T0) were selected as control group．Results The levels of thyroid hormones were different among three periods o f pregnant women．TSH were 0.25～5.32，0.42～6.26 and 0.61～7.68 mI U/L respectively in the early，middle and late stages．FT3 were 3.54～6.04，3 .57～5.94 and 2.93～5.40 pmol/L，respectively.FT4 was 7.11～16.88，6.78～ 16.94 and 6.03～16.87 pmol/L．Thyroid hormone leve ls in pregnant women compared with non-pregnant women，there were significant d ifferences (TSH:χ2=233.183，P<0.05，FT4:χ2=388.12，P<0.05 an d FT3:χ2=558.795，P<0.05)．TSH were lower in early pregnant women com paring to non-pregnancy women，and higher in middle-late pregnant women．The c hange of FT3 and FT4 were consistent，and reduced with the extension of pregnanc y comparing to non-pregnancy women．Conclusion The level of thyroid function in pregnant women were different from non-pregnant women． and the normal reference range of local pregnant specific thyroid hormone should be established．

参考文献/References:

［1］ Stagnaro-Green A，Abalovich M，Alexander E，et al．Guidelines of the American thyroid association for the diagnosis and management of thyroid di sease during pregnancy and postpartum［J］．Thyroid，2011，21(10)：1081-1125．
［2］ Baloch Z，Carayon P,Conte-Devolx B,et al．Laboratory medicine practice guidelines：laboratory support for the diagnosis and monitoring of thyroid dise ase［J］．Thyroid，2003：13(1)：3-126．
［3］ 李建新，王 森，单忠艳，等．妊娠早期母体甲状腺功能及其抗体异常对妊娠结局 的影响［J］．中华内分泌代谢杂志，2011，27(11)：916-919． Li JX，Wang S，Shan ZY,et al．The impact of maternal thyroid disease s on the pregna nt outcome in the first trimester of pregnancy［J］．Chinese Journal of Endocrin ology and Metabolism，2011，27(11)：916-919．
［4］ 武 敏，吴桂清，李 静．西安地区妊娠期妇女甲状腺功能测定及其临床意义［J］ ．陕西医学杂志，2015，44(5)：610-611． Wu M，Wu GQ，Li J．Detection of thyroid function during pregnancy i n Xi’an and its clinical significance［J］．Shaanxi Medical Journal，2015，44(5 )：610-611．
［5］ 罗 军，韩 密，宋梦帆，等．两种免疫试剂检测妊娠期甲状腺功能结果的比较［J ］．中华围产医学杂志，2012，15(7)：404-410． Luo J，Han M，Song MF，et al．Comparison of thyroid function tests r esults determined by two kinds of immunoassay in uncomplicated pregnant women［J ］.Chinese Journal of Perinatal Medicine，2012，15(7)：404-410．
［6］ 黄 华，谭梦霞，陈林兴，等．潮汕地区妊娠妇女甲状腺功能指标参考范围探讨［J ］．国际检验医学杂志，2015，36(16)：2309-2311． Huang H，Tan MX，Chen LX，et al．The investigation of thyroid functi on reference range during pregnancy in Chaoshan area［J］.International Journal of Laboratory Medicine，2015，36(16)：2309-2311．
［7］ 舒小雨，漆洪波，蒋利华，等．BECKMAN试剂检测妊娠各期特异性甲状腺功能指标正 常值范围研究［J］．中国实用内科杂志，2014，33(11)：881-884． Shu XY，Qi HB，Jiang LH，et al．Establishment of trimester-specific reference intervals for thyroid tests detcted by BECKMAN assay［J］．Chinese Jo urnal of Practical Internal Medicine，2014,33(11)：881-884．
［8］ 王群仙，陈友好，何俊英，等．正常孕妇不同孕期甲状腺激素水平研究［J］．浙江 预防医学，2015，27(2)：187-188，203． Wang QX，Chen YH，He JY，et al．Study on thyroid hormone levels in n ormal p regnant women during different periods of pregnancy［J］.Zhejiang Journal of Pr eventive Medicine，2015，27(2)：187-188，203．

相似文献/References:

[1]谭婷婷,陈雨欣,程 莉,等.不同妊娠期妇女碘营养状况与甲状腺功能检测研究[J].现代检验医学杂志,2017,32(03):115.[doi:10.3969/j.issn.1671-7414.2017.03.031]
　TAN Ting-ting,CHEN Yu-xin,CHENG Li,et al.Investigation of Iodine Nutritional Status and Thyroid Function in Pregnant Women During Different Periods[J].Journal of Modern Laboratory Medicine,2017,32(03):115.[doi:10.3969/j.issn.1671-7414.2017.03.031]
[2]陈小娟a,邱敏娟a,高 飞a,等.广州地区孕妇尿碘水平与甲状腺功能减退的相关性分析[J].现代检验医学杂志,2019,34(02):119.[doi:10.3969/j.issn.1671-7414.2019.02.030]
　CHEN Xiao-juana,QIU Min-juana,GAO Feia,et al.Analysis of the Correlation between Urinary Iodine Leveland Hypothyroidism in Pregnant Women in Guangzhou[J].Journal of Modern Laboratory Medicine,2019,34(03):119.[doi:10.3969/j.issn.1671-7414.2019.02.030]
[3]申文娟,李园春,姚若冰.孕前和孕期母体外周血血红蛋白浓度与发生胎儿死产风险的相关性研究[J].现代检验医学杂志,2019,34(04):139.[doi:10.3969/j.issn.1671-7414.2019.04.034]
　SHEN Wen-juan,LI Yuan-chun,YAO Ruo-bing.Correlation between Maternal Peripheral Blood Hemoglobin Concentration and Risk of Fetal Stillbirth before and During Pregnancy[J].Journal of Modern Laboratory Medicine,2019,34(03):139.[doi:10.3969/j.issn.1671-7414.2019.04.034]
[4]杨荣荣,张 萍.外周血液狼疮抗凝物质比值及Ｔ细胞免疫球蛋白黏蛋白分子３水平与孕早期复发性流产的相关性研究[J].现代检验医学杂志,2020,35(01):60.[doi:10.3969/j.issn.1671-7414.2020.01.016]
　YANG Rong-rong,ZHANG Ping.Study on the Relationship between Ratio of Lupus Anticoagulant and Levels of T-cell Immunoglobulin-Mucin Molecule 3 in Peripheral Blood and Recurrent Abortion in Early Pregnancy[J].Journal of Modern Laboratory Medicine,2020,35(03):60.[doi:10.3969/j.issn.1671-7414.2020.01.016]
[5]马 润,沈秀芬,陈孝红,等.昆明地区不同妊娠期妇女甲状腺功能指标参考区间的调查及变化分析[J].现代检验医学杂志,2020,35(01):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]
　MA Run,SHEN Xiu-fen,CHEN Xiao-hong,et al.nvestigation and Change Analysis of Reference Intervals ofThyroid Function Indicators for Women at Different Stages of Pregnancy in Kunming[J].Journal of Modern Laboratory Medicine,2020,35(03):97.[doi:10.3969/j.issn.1671-7414.2020.01.026]
[6]黄明兰,柯晓斯,彭致平,等.正常妊娠期妇女低色素性贫血对糖化血红蛋白水平检测的影响[J].现代检验医学杂志,2021,36(02):151.[doi:doi:10.3969/j.issn.1671-7414.2021.02.036]
　HUANG Ming-lan,KE Xiao-si,PENG Zhi-ping,et al.Effect of Hypopigmentation Anemia on Glycosylated Hemoglobin in Normal Pregnant Women[J].Journal of Modern Laboratory Medicine,2021,36(03):151.[doi:doi:10.3969/j.issn.1671-7414.2021.02.036]
[7]魏　巍a,张　旭a,李婉娇a,等.临床甲亢和亚临床甲亢患者血清 Nrg4，TSK水平与血脂、甲状腺激素和基础代谢率的相关性分析[J].现代检验医学杂志,2022,37(01):38.[doi:10.3969/j.issn.1671-7414.2022.01.008]
　WEI Weia,ZHANG Xua,LI Wan-jiaoa,et al.Correlation Analysis of Serum Nrg4, TSK Levels with Blood Lipids, Thyroid Hormones and Basal Metabolic Rate in Patientswith Clinical Hyperthyroidism and Subclinical Hyperthyroidism[J].Journal of Modern Laboratory Medicine,2022,37(03):38.[doi:10.3969/j.issn.1671-7414.2022.01.008]
[8]孔丽蕊,周朝琼,何大海,等.基于生物学变异数据建立血清甲状腺激素的个性化参考区间[J].现代检验医学杂志,2023,38(05):148.[doi:10.3969/j.issn.1671-7414.2023.05.028]
　KONG Lirui,ZHOU Chaoqiong,HE Dahai,et al.Establish Serum Thyroid Hormones Based on Biological Variation Data Personalized Reference Intervals[J].Journal of Modern Laboratory Medicine,2023,38(03):148.[doi:10.3969/j.issn.1671-7414.2023.05.028]
[9]龙 琴,石安惠,黄佳蓉.四川宜宾地区不同孕期妇女血浆可溶性纤维蛋白单体复合物水平参考范围的建立[J].现代检验医学杂志,2024,39(01):166.[doi:10.3969/j.issn.1671-7414.2024.01.031]
　LONG Qin,SHI Anhui,HUANG Jiarong.Establishment of Reference Ranges for Plasma Soluble Fibrin Monomer Complex Level at Different Gestational Periods of Women in Yibin Area of Sichuan[J].Journal of Modern Laboratory Medicine,2024,39(03):166.[doi:10.3969/j.issn.1671-7414.2024.01.031]
[10]周莉莉,刘 栋,宋宏庆.陕西省铜川地区妊娠妇女血清甲状腺激素水平参考范围的建立及临床应用[J].现代检验医学杂志,2022,37(05):164.[doi:10.3969/j.issn.1671-7414.2022.05.032]
　ZHOU Li-li,LIU Dong,SONG Hong-qing.Establishment and Clinical Application of Reference Intervals of Serum Thyroid Hormone Level of Pregnant Women in Tongchuan[J].Journal of Modern Laboratory Medicine,2022,37(03):164.[doi:10.3969/j.issn.1671-7414.2022.05.032]

备注/Memo

备注/Memo:

作者简介：张 洁(1972-)，女，大学本科，副主任技师，从事核医学体外检测工作，主 要研究内分泌激素及肿瘤标志物检测，Tel：18992695209，E-mail：609037148@qq.com。
更新日期/Last Update: 2017-06-25