[1]唐元艳,张利铭,张江召,等.骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析[J].现代检验医学杂志,2017,32(06):71-73.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　TANG Yuan-yan,ZHANG Li-ming,ZHANG Jiang-zhao,et al.Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients[J].Journal of Modern Laboratory Medicine,2017,32(06):71-73.[doi:10.3969/j.issn.1671-7414.2017.06.001]
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骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年06期
页码:
71-73
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients
文章编号:
1671-7414(2017)06-071-03
作者:
唐元艳; 张利铭; 张江召; 熊 涛; 梁 艳; 余卓君; 刘荟敏; 刘 敏; 黄知平
华中科技大学同济医学院附属荆州医院血液内科,湖北荆州 434020
Author(s):
TANG Yuan-yan; ZHANG Li-ming; ZHANG Jiang-zhao; XIONG Tao;  LIANG Yan; YU Zhuo-jun; LIU Hui-min; LIU Min; HUANG Zhi-ping
Department of Hematology,Jingzhou Hospital Affilited to TongjiMedical College of Huazhong University of Science and Technology,Hubei Jingzhou 434020,China
关键词:
骨髓增生异常综合征;  发育异常;  荧光原味杂交
分类号:
R551.3; R446.113
DOI:
10.3969/j.issn.1671-7414.2017.06.001
文献标志码:
A
摘要:
目的 总结分析骨髓增生异常综合征患者(MDS)细胞形态学异常与染色体异常的相关性。方法 回顾性分析82例MDS患者完整的病例资料,探讨MDS细胞形态学异常与FISH检测染色体异常的相关性。结果 82例MDS患者中,染色体异常45例,+8为出现频率最高的染色体异常,其中单纯+8异常8例,-5和5q-各6例、20q- 7例、-7和7q-各5例、复杂核型(>3种异常)6例、+8伴20q- 1例,5q-伴20q- 1例。核型异常组与核型正常组之间原始细胞比例、幼红细胞巨幼样变及核畸形、巨核细胞系发育异常(单圆核巨核细胞、多圆核巨核细胞、小巨核细胞)比例差异有统计学意义(P<0.05)。高危组与低危组间、低危组与中危组间核型异常比例差异有统计学意义(P<0.05)。结论 MDS患者的染色体异常与形态学改变可能相关。
Abstract:
Abstract:Objective To investigate the correlation between morphological abnormalities and abnormal myelodysplastic syndromes(MDS)cloning.Methods 82 cases of MDS were collected with completeFISH and morphological abnormalities.The relationship between MDS cell morphology and chromosome abnormality was investigated.Results 45 cases of chromosomal abnormalities were found,and +8 were the most frequent chromosomal abnormalities.8 cases were +8,-5 and 5q- were 6,20q- were 7,-7and 7q- were 5,complex karyotypes(>3 abnormalities)were 6.There were statistically significant differences in the proportion of primordial cells,megakaryocyte dysplasia,megakaryocyte abnormalities between karyotype abnormal group andkaryotype normal group(P<0.05).There were statistically significant differences in the proportion of abnormal karyotype among high risk group and low risk group,the low risk group and medium risk group(P<0.05).Conclusion The chromosomal abnormalities of MDS patients would be relatedto morphological changes.

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备注/Memo

备注/Memo:
作者简介:唐元艳(1980-),女,副主任医师,主要从事血液病规范化诊疗,E-mail:huangsir8@126.com。
更新日期/Last Update: 2017-12-26