[1]李文生,周小鸽.关于淋巴瘤概念及诊断标准的再思考和认识——兼“低度恶性潜能淋巴肿瘤”病理诊断名词的提出[J].现代检验医学杂志,2018,33(02):1-4，7.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　LI Wen-sheng,ZHOU Xiao-ge.Rethink and Understanding of the Concept and Diagnostic Criteria of Lymphoma —Presentation of the Concept of “Low-Grade Malignant Potential Lymphoid Neoplasms”[J].Journal of Modern Laboratory Medicine,2018,33(02):1-4，7.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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关于淋巴瘤概念及诊断标准的再思考和认识——兼“低度恶性潜能淋巴肿瘤”病理诊断名词的提出()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
1-4，7
栏目:
述评
出版日期:
2018-04-05

文章信息/Info

Title:
Rethink and Understanding of the Concept and Diagnostic Criteria of Lymphoma —Presentation of the Concept of “Low-Grade Malignant Potential Lymphoid Neoplasms”
文章编号:
1671-7414(2018)02-001-05
作者:
李文生1; 周小鸽2
1.陕西省人民医院/西安交通大学第三附属医院病理科,西安 710068; 2.首都医科大学附属北京友谊医院病理科,北京 100050
Author(s):
LI Wen-sheng1; ZHOU Xiao-ge2
1.Department of Pathology, Shaanxi Provincial People's Hospital/the Third Affiliated Hospital of the Medicine School of Xi'an Jiaotong University,Xi'an 710068,China; 2.Department of Pathology, Beijing Friendship Hospital,Capital Medicine University,Beijing 100050,China
关键词:
近年来新发现一类生物学行为偏良性的单克隆增生淋巴组织病变; 常被诊断为淋巴瘤; 但其病变恶性潜能十分有限; 几乎不进展; 这对传统淋巴瘤概念及诊断标准都是一个挑战。基于此; 笔者在理论层面提出了“良性淋巴瘤”的概念并从克隆性及淋巴细胞流动性两个方面探讨了其存在的可能性; 同时基于临床实践及诊断策略层面考虑; 又首次提出“低度恶性潜能淋巴肿瘤”新的病理诊断名词; 既表明这类病变不同于恶性淋巴瘤; 避免过度治疗; 同时又提醒临床和患者注意随访观察; 防止少数病例复发。希望通过此文引发学者们对淋巴瘤生物学本质的共同思考和探讨。
分类号:
R446.8
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
近年来新发现一类生物学行为偏良性的单克隆增生淋巴组织病变,常被诊断为淋巴瘤,但其病变恶性潜能十分有限,几乎不进展,这对传统淋巴瘤概念及诊断标准都是一个挑战。基于此,笔者在理论层面提出了“良性淋巴瘤”的概念并从克隆性及淋巴细胞流动性两个方面探讨了其存在的可能性,同时基于临床实践及诊断策略层面考虑,又首次提出“低度恶性潜能淋巴肿瘤”新的病理诊断名词,既表明这类病变不同于恶性淋巴瘤,避免过度治疗,同时又提醒临床和患者注意随访观察,防止少数病例复发。希望通过此文引发学者们对淋巴瘤生物学本质的共同思考和探讨。
Abstract:
Abstract:Some monoclonal lymphoid tissue lesions showingbenign biological behavior have been found recently,they usually were diagnosedwith lymphoma,their malignant potential is extremely limited and almost does not develop.However,it presents a challenge to the concept of lymphoma and itsdiagnostic standard.Based on this,the auther propose the concept of “benign lymphoma” at the theoretical level,and discusses the possibility of its existence from two aspects of clonality and lymphocyte fluidity.At the same time,based on clinical practice and diagnostic strategies,propose the “Low-grade malignant potential lymphoid neoplasms “diagnostic terms for the first time,on theone hand,it show that this type of lesion is different from lymphoma and avoidsovertreatment,on the other hand,clinicians and patients were reminded to follow up observation to prevent recurrence of a small number of cases, so as to trigger the discussion on the biological essence of lymphoma.

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备注/Memo

备注/Memo:
基金项目:陕西省科技攻关课题(2010K12-02); 陕西省卫生计生科研基金(2016D035)。 作者简介:李文生(1968-),男,医学博士,主任医师,研究方向:肿瘤病理诊断及淋巴瘤病理及发病机制研究,E-mail:liwensheng263@sohu.com。 周小鸽(1959-),男,主任医师,研究方向:淋巴瘤、EB病毒相关性淋巴增殖性疾病、免疫组织化学,E-mail:zhouxiaoge59@hotmail.com。
更新日期/Last Update: 2018-04-16