[1]纪逸群,姚佳璐,何 杨.细胞外泛素及其受体CXCR4与AMI相关性研究进展[J].现代检验医学杂志,2019,34(02):160-164.[doi:10.3969/j.issn.1671-7414.2019.02.041]
 JI Yi-qun,YAO Jia-lu,HE Yang.Research Progress of Extracellular Ubiquitinand Its Receptor CXCR4 in Acute -Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2019,34(02):160-164.[doi:10.3969/j.issn.1671-7414.2019.02.041]
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细胞外泛素及其受体CXCR4与AMI相关性研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
160-164
栏目:
综述
出版日期:
2019-05-11

文章信息/Info

Title:
Research Progress of Extracellular Ubiquitinand Its Receptor CXCR4 in Acute -Myocardial Infarction
文章编号:
1671-7414(2019)02-160-05
作者:
纪逸群1姚佳璐2何 杨1
(1.苏州大学唐仲英血液学研究中心,江苏苏州 215123; 2.南京医科大学附属苏州医院/苏州市立医院,江苏苏州 215008)
Author(s):
JI Yi-qun1YAO Jia-lu2HE Yang1
(1.Cyrus Tang Hematology Center,Soochow University,Jiangsu Suzhou 215123,China; 2.Suzhou Hospital Affiliatedto Nanjing Medical University/Suzhou Municipal Hospital,Jiangsu Suzhou215008,China)
关键词:
细胞外泛素 趋化因子受体4(CXCR4) 急性心肌梗死
分类号:
R542.3; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.02.041
文献标志码:
A
摘要:
急性心肌梗死为供养心肌的冠状动脉在粥样硬化斑块基础上发生急性、持久性缺血缺氧所致的心肌坏死,是全球死亡率最高的疾病之一。提高梗死区心肌细胞的存活、逆转进行性心室重构是提高预后的关键。泛素是细胞内参与蛋白质降解的小分子多肽,而体液中的细胞外泛素可通过受体CXCR4发挥多种功能。近来相关研究显示细胞外泛素及其受体CXCR4对心肌组织的细胞形态和功能均有影响,对急性心肌梗死(AMI)后心肌组织具有保护作用,笔者将对此作一综述,以期为解决AMI难题提供新的思路和靶点。
Abstract:
Acute myocardial infarction is one of the most deadly diseases in the world.Promoting cardiomyocytes survival in the infarctedarea and reversing the myocardial remodeling are the keys to improve the prognosis of AMI.Ubiquitin is a small polypeptide involved in protein degradation in cells,whereas extracellular ubiquitin in body fluid can function through its receptor CXCR4.Recent studies have shown that extracellular ubiquitin and CXCR4 have effects on the morphology and function of cardiomyocytes and can efficientlyimprove the heart function and survival after myocardial infarction.This reviewsummarizes the role of extracellular ubiquitin in myocardial remodeling and mayprovide a new and potentially useful therapy for solving the problem of acute myocardial infarction(AMI).

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81700235)。 作者简介:纪逸群(1994-),女,在读硕士研究生,学士学位,专业:临床检验诊断学,E-mail:475099453@qq.com。 通讯作者:何 杨,E-mail:heyang1963@163.com。 收稿日期:2019-02-25 修回日期:2019-03-14
更新日期/Last Update: 2019-04-30