[1]武小亮,韩 娟,王 靖,等.外周血T细胞受体删除环(TRECs)定量测定在评估骨髓移植术后免疫重建中的应用概况及进展[J].现代检验医学杂志,2019,34(04):1-5.[doi:10.3969/j.issn.1671-7414.2019.04.001]
 WU Xiao-liang,HAN Juan,WANG Jing,et al.Quantitative Determination of Peripheral Blood T Cell Receptor Rearrangement Excision Circle(TRECs)and Its Application and Progress in Evaluating Immune Reconstitution after Bone Marrow Transplantation[J].Journal of Modern Laboratory Medicine,2019,34(04):1-5.[doi:10.3969/j.issn.1671-7414.2019.04.001]
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外周血T细胞受体删除环(TRECs)定量测定在评估骨髓移植术后免疫重建中的应用概况及进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
1-5
栏目:
述评
出版日期:
2019-08-20

文章信息/Info

Title:
Quantitative Determination of Peripheral Blood T Cell Receptor Rearrangement Excision Circle(TRECs)and Its Application and Progress in Evaluating Immune Reconstitution after Bone Marrow Transplantation
文章编号:
1671-7414(2019)04-001-06
作者:
武小亮韩 娟王 靖卢林纲
(农业农村部食物与营养发展研究所评价研究室,北京 100081)
Author(s):
WU Xiao-liangHAN JuanWANG JingLU Lin-gang
(Food and Nutrition Assessment Lab, Institute of Food and Nutrition Development,Ministry of Agriculture,Beijing 100081,China)
关键词:
T细胞受体删除环(TRECs) 骨髓移植 免疫重建
分类号:
R457.7; R392.4
DOI:
10.3969/j.issn.1671-7414.2019.04.001
文献标志码:
A
摘要:
骨髓移植成功的关键在于移植后免疫系统的重建状况,特别是T细胞数量及功能的重建。T细胞受体删除环(TRECs)作为胸腺近期输出naive T细胞含量的标志,在细胞中十分稳定,可作为评价胸腺近期的输出功能及T细胞免疫重建状况的指标。鉴于TRECs对评价骨髓移植术后免疫重建状况具有重要现实意义,该文就TRECs的定量检测及其在评价骨髓移植后免疫重建状况中的应用概况及进展进行综述。
Abstract:
The key to success of bone marrow transplantation depends on the immune reconstitution after transplantation,Especially thereconstruction of the number and function of T cells.T cell receptor rearrangement excision circle(TRECs)represent the number of naive T cell of thymus output,and are very stable in cells,which can be used as an index to evaluate the recent thymic emigrants and T cell immune reconstitution.In view of the important practical significance of TRECs in evaluating immune reconstitution afterbone marrow transplantation.The article will review the quantitative detectionof TRECs and its application and progress in evaluation of immune reconstitution after bone marrow transplantation.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(31802306); 中国农业科学院创新工程项目(CAAS ASTIP32018IFND)。 作者简介:武小亮(1994-),男,硕士研究生,研究方向:食物营养与健康,E-mail: 82101172218@caas.cn。 通讯作者:韩娟(1983-),E-mail:hanjuan@caas.com。收稿日期:2019-05-05 修回日期:2019-05-15
更新日期/Last Update: 2019-07-30