[1]王阳斌,夏永泉.银纳米颗粒与抗生素对耐甲氧西林金黄色葡萄球菌的协同抗菌效应研究[J].现代检验医学杂志,2019,34(05):130-132.[doi:10.3969/j.issn.1671-7414.2019.05.032]
 WANG Yang-bin,XIA Yong-quan.Study on Synergistic Antibacterial Effect of Silver Nanoparticles and Antibiotics on Methicillin-Resistant Staphylococcus Aureus[J].Journal of Modern Laboratory Medicine,2019,34(05):130-132.[doi:10.3969/j.issn.1671-7414.2019.05.032]
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银纳米颗粒与抗生素对耐甲氧西林金黄色葡萄球菌的协同抗菌效应研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
130-132
栏目:
研究简报·实验技术
出版日期:
2019-10-29

文章信息/Info

Title:
Study on Synergistic Antibacterial Effect of Silver Nanoparticles and Antibiotics on Methicillin-Resistant Staphylococcus Aureus
文章编号:
1671-7414(2019)05-130-03
作者:
王阳斌夏永泉
(南京大学医学院附属鼓楼医院检验科,南京 210008)
Author(s):
WANG Yang-binXIA Yong-quan
(Department of Laboratory Medicine,Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)
关键词:
银纳米颗粒 耐甲氧西林金黄色葡萄球菌 抗生素 细菌耐药
分类号:
R378.11; R446.5
DOI:
10.3969/j.issn.1671-7414.2019.05.032
文献标志码:
A
摘要:
目的 观察传统抗生素与银纳米颗粒联用时的体外抗菌效果。方法 以耐甲氧西林金黄色葡萄球菌为研究对象,通过纸片扩散法评估银纳米颗粒与抗生素联用时的协同抗菌效应。结果 青霉素、红霉素、头孢西丁、阿米卡星等传统抗生素的抑菌效果在与银纳米颗粒联用后均出现了不同程度的增强,抑菌环增比率可达0.62~3.69。结论 传统抗生素与银纳米颗粒之间具有协同抗菌效应,两者结合使用可有效提高抗菌效率,降低临床抗生素的使用量。
Abstract:
Objective To observe the antibacterial effect of traditional antimicrobial drugs in vitro when associated with silver nanoparticles.Methods Used methicillin-resistant Staphylococcus aureus as the research object,the antibacterial effect of silver nanoparticles and antimicrobial drugs was tested by paper diffusion method.Results The bacteriostatic effects of penicillin,erythromycin,cefoxitin,a Amikacin and other traditional antimicrobial agents were enhanced in different degrees after being used in connection with silver nanoparticles,and thebacteriostatic ring increase rate could reach 0.62~3.69.ConclusionThere is a synergistic antibacterial effect between traditional antimicrobial drugs and silver nanoparticles,both of which can effectively improveantimicrobial efficiency and reduce the amount of clinical antibiotics used.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:王阳斌(1976-),男,大学本科,技师,主要从事检验技术研究,E-mail: 438090040@qq.com。 通讯作者:夏永泉,男,副主任技师,主要从事检验技术研究,E-mail:xyq2002xyq@aliyun.com。
更新日期/Last Update: 2019-10-20