[1]陈健康,彭道荣,陈慧昱,等.尿液膀胱肿瘤抗原水平检测在膀胱癌诊断中的意义[J].现代检验医学杂志,2019,34(06):135-137.[doi:10.3969 ／ j.issn.1671-7414.2019.06.034]
　CHEN Jian-kang,PENG Dao-rong,CHEN Hui-yu,et al.Significance of Urine Bladder Tumor Antigen Level in the Diagnosis of Bladder Cancer[J].Journal of Modern Laboratory Medicine,2019,34(06):135-137.[doi:10.3969 ／ j.issn.1671-7414.2019.06.034]
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尿液膀胱肿瘤抗原水平检测在膀胱癌诊断中的意义 ()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
135-137
栏目:
检验与临床
出版日期:
2019-12-30

文章信息/Info

Title:
Significance of Urine Bladder Tumor Antigen Level in the Diagnosis of Bladder Cancer
文章编号:
1671-7414（2019）06-135-03
作者:
陈健康; 彭道荣; 陈慧昱; 房　艳; 邢瑞青; 刘　杨; 吴永昌
（空军军医大学第一附属医院检验科，西安　710032）
Author(s):
CHEN Jian-kang;  PENG Dao-rong;  CHEN Hui-yu;  FANG Yan;  XING Rui-qing;  LIU Yang;  WU Yong-chang
（Department of Clinical Laboratory, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032,China）
关键词:
膀胱癌; 尿液膀胱癌肿瘤抗原; 化学发光; 标志物
分类号:
R737.14；R730.43
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.034
文献标志码:
A
摘要:
目的 　评估尿液膀胱肿瘤抗原（BTA）水平在膀胱癌诊断中的价值。方法　收集98 例膀胱癌患者、57 例非膀 胱癌患者以及68 例健康体检者晨尿标本，利用化学发光分析仪进行各样本中BTA 水平的检测。通过ROC 曲线下面积 计算，分析BTA 对膀胱癌的诊断灵敏度、特异度及最佳临界值。结果　膀胱癌患者尿液中BTA 水平[486.56（66.27， 2 013.81）] U/ml 明显高于健康对照组[25.71（10.40，53.39）] U/ml 及非膀胱癌组[55.47（26.55，296.24）] U/ml，差异 具有统计学意义（χ2=64.172，P <0.01）；BTA 诊断膀胱癌的ROC 曲线下面积为0.816，与参考线下面积相比，差异具 有统计学意义（P <0.01），BTA 诊断膀胱癌的最佳临界值为84.38U/ml，诊断敏感度为70.8%，特异度为93.5%。结论　 尿液BTA 的检测在膀胱癌的诊断筛查中具有较高的临床价值，可用于膀胱癌的早期筛查。
Abstract:
Objective　To evaluate the application value of urinary bladder tumor antigen (BTA) detection in the diagnosis of bladder cancer. Methods　The morning urine was collected respectively from the 98 bladder cancer samples, 57 patients with non-bladder cancer, and 68 healthy subjects. The level of BTA was detected using a chemiluminescence analyzer. Through the calculation of the area under the ROC curve, analyzed the sensitivity, specificity and optimal threshold of BTA for the diagnosis of bladder cancer. Results　The level of BTA in the urine of patients with bladder cancer [486.56（66.27，2013.81）] U/ml was significantly higher than that of the normal control group[25.71（10.40，53.39）] U/ml and non-bladder cancer patients group[55.47（26.55，296.24）] U/ml, and significant difference was shown (χ2=64.172，P <0.01). The area under the ROC curve for the diagnosis of bladder cancer of BTA was 0.816, compared with the area under the reference line, which was significant difference (P <0.01). The cut-off value for BTA diagnosis of bladder cancer was 84.38 U/ml, the diagnostic sensitivity was 70.8%,and the specificity was 93.5%.Conclusion 　Detection of urinary BTA has a higher clinical value in the diagnosis of bladder cancer, and can be used for early screening of bladder cancer.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：陈健康（1991-）男, 硕士, 初级技师, 主要从事临床免疫学检验工作，E-mail:chengjiankang1934@163.com。 通讯作者：吴永昌，E-mail：sxxawyc@163.com。收稿日期：2019-08-04
更新日期/Last Update: 2019-12-25