[1]薛飞肖,王海峰,李琼阁a,等.神经退行性疾病与载脂蛋白E 基因及多种心脑血管因素的相互影响分析[J].现代检验医学杂志,2020,35(01):9-12.[doi:10.3969/j.issn.1671-7414.2020.01.003]
　XUE Fei-xiao,WANG Hai-feng,LI Qiong-gea,et al.Study on the Interaction between Neurodegenerative Diseases and Apolipoprotein E Gene and Various Cardiovascular and Cerebrovascular Factors[J].Journal of Modern Laboratory Medicine,2020,35(01):9-12.[doi:10.3969/j.issn.1671-7414.2020.01.003]
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神经退行性疾病与载脂蛋白E 基因及多种心脑血管因素的相互影响分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
9-12
栏目:
论　　著
出版日期:
2020-02-29

文章信息/Info

Title:
Study on the Interaction between Neurodegenerative Diseases and Apolipoprotein E Gene and Various Cardiovascular and Cerebrovascular Factors
文章编号:
1671-7414(2020)01-009-04
作者:
薛飞肖1; 王海峰1; 李琼阁2a; 郭桂萍3; 张璐璐2b; 关 月3
(1.西安市第三医院检验科,西安 710018; 2.西安市第四医院 a.药剂科; b. 神经内科,西安 710004; 3.空军军医大学西京医院药剂科,西安710032)
Author(s):
XUE Fei-xiao1; WANG Hai-feng1; LI Qiong-ge2a; GUO Gui-ping3; ZHANG Lu-lu2b;  GUAN Yue3
(1. Department of Clinical Laboratory, the Third Hospital of Xi'an, Xi'an 710018,China; 2a.Department of Pharmacy; 2b.Department of Neurology, the Fourth Hospital ofXi'an,Xi'an 710004,China; 3. Department of Pharmacy, Xijing Hospital of Air Force Medical University,Xi'an 710032,China)
关键词:
载脂蛋白E;  神经退行性疾病;  血脂;  心脑血管疾病
分类号:
R749.16; R446.11
DOI:
10.3969/j.issn.1671-7414.2020.01.003
文献标志码:
A
摘要:
目的 分析神经退行性疾病(neurodegenerative diseases,ND)与载脂蛋白E(apolipoprotein E,ApoE)基因及多种心脑血管因素的相互影响。方法 回顾性收集2017年8月～2019年7月住院的阿尔茨海默病(Alzheimer's Disease,AD)、血管性痴呆(Vascular Dementia,VD)、帕金森病(Parkinson's Disease,PD)、轻度认知功能障碍(mild cognitive impairment,MCI)及其他痴呆患者的ApoE基因型、心脑血管因素、血脂水平等指标,并对其与ND疾病相互影响进行统计分析。结果 患者年龄、是否患有高血压及脑梗死史对ND不同病种存在影响,差异具有统计学意义(χ2=88.691,F=45.429,46.691,均P<0.05),其中AD年龄最高,其次是VD; 同时高血压史可能与AD(61.90%)及VD(85.71%)增加相关,脑梗死史可能与MCI(96.43%)及VD(63.53%)增加相关。ND患者ApoE基因型均以ε3/ε3基因型为主,其中AD中携带ε4基因患者(47.62%)高于VD(21.43%),PD(25.00%),MCI(20.00%)及其他痴呆(28.00%)患者,差异具有统计学意义(χ2=11.687,P<0.05),而携带ε2基因的患者比例相当,差异无统计学意义(χ2=0.531,P>0.05)。不同ApoE基因型之间总胆固醇(TC)水平比较,差异具有统计学意义(F=4.932,P<0.05),同时亚组分析指出携带ε2基因患者TC水平<ε3/ε3患者<携带ε4基因患者。结论 ND可能是年龄、ApoE基因、高血压、脑梗死等多种因素作用的结果,这对ND的早期诊断具有一定参考价值。
Abstract:
Objective To analyze on the interaction between neurodegenerative diseases(ND)and apolipoprotein E(Apo E)gene and various cardiovascular and cerebrovascular factors. Methods Retrospective collection of hospitalized patients with Alzheimer's Disease(AD), Vascular Dementia,(VD), Parkinson's Disease(PD), Mild Cognitive Impairment(MCI)and other indicators of dementia patients' ApoE genotype, cardiovascular and cerebrovascular factors, blood lipid level and other indicators were analyzed statistically. Results The age of the patients, the history of hypertension and cerebral infarction had statistical significance(χ2=88.691,F=45.429,46.691,all P<0.05), among which the age of AD was the highest, followed by VD. Meanwhile, the history of hypertension could be associated with increased AD(61.90%), VD(85.71%), and the history of cerebral infarction couldbe associated with increased MCI(96.43%)and VD(63.53%). The ApoE genotypes of ND patients were dominated by epsilon 3/epsilon 3 genotypes, among which patients with epsilon 4 gene in AD group(47.62%)were higher than VD(21.43%),PD(25.00%),MCI(20.00%)and other dementia patients(28.00%), and the difference was statistically significant(χ2=11.687, P<0.05), but patients with epsilon 2 gene were the same, and the difference was not statistically significant(χ2=0.531, P>0.05).The difference in TC level between different ApoE genotypes was statistically significant(F=4.932,P<0.05),simultaneous subcomponet the TC level of patients was with epsilon 2 gene < epsilon 3/epsilon 3<epsilon 4. Conclusion The development of ND may be the result of a combination of age, ApoE gene, hypertension, cerebral infarction and other factors, this has certain reference value for the early diagnosis of ND.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(项目编号:2018SF-090),西安市第四医院院内孵化基金项目(项目编号:FZ-31)。 作者简介:薛飞肖(1990-),女,硕士,主管检验技师,研究方向:神经系统疾病研究,E-mail:xuefx0225@sina.com。 通讯作者:关月,女,博士,副主任药师,研究方向:神经系统疾病发病机理研究,E-mail:23395691@qq.com。 收稿日期:2019-10-15 修回日期:2019-11-18
更新日期/Last Update: 2020-03-30