[1]茹 平,黄 刚.桥本甲状腺炎患者外周血液MCP-1 和CD195 水平检测的临床意义及相关性研究[J].现代检验医学杂志,2020,35(01):86-89.[doi:10.3969/j.issn.1671-7414.2020.01.023]
　RU Ping,HUANG Gang.Clinical Significance and Correlation of Levels of MCP-1 and CD195 in Peripheral Blood of Patients with Hashimoto’s Thyroiditis[J].Journal of Modern Laboratory Medicine,2020,35(01):86-89.[doi:10.3969/j.issn.1671-7414.2020.01.023]
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桥本甲状腺炎患者外周血液MCP-1 和CD195 水平检测的临床意义及相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
86-89
栏目:
论　　著
出版日期:
2020-02-29

文章信息/Info

Title:
Clinical Significance and Correlation of Levels of MCP-1 and CD195 in Peripheral Blood of Patients with Hashimoto’s Thyroiditis
文章编号:
1671-7414(2020)01-086-04
作者:
茹 平1; 黄 刚2
(1.西安市第八医院检验科,西安 710061; 2.陕西中医药大学附属医院检验科, 陕西 咸阳 712000)
Author(s):
RU Ping1; HUANG Gang2
(1. Department of Clinical Laboratory,the Eighth Hospital of Xi’an, Xi’an 710061,China; 2.Affiliated Hospital of Traditional Chinese Medicine University of Shaanxi, Shaanxi Xianyang 712000,China)
关键词:
桥本甲状腺炎;  甲状腺功能减退;  峡部厚径;  收缩期峰值流速;  单核细胞趋化蛋白1;  白细胞分化抗原195
分类号:
R581.4; R392.11
DOI:
10.3969/j.issn.1671-7414.2020.01.023
文献标志码:
A
摘要:
目的 探讨桥本甲状腺炎(Hashimoto’s thyroiditis,HT)患者外周血液单核细胞趋化蛋白1(monocyte chemotactic protein 1,MCP-1)及白细胞分化抗原(cluster of differentiation,CD)195水平检测的临床意义及相关性。方法 选择2017年7月～2019年 7月在西安市第八医院和陕西中医药大学附属医院就诊的82例HT患者作为研究对象,依据患者的甲状腺功能状况分为正常组(40例)和甲状腺功能减退组(甲减组,42例),选择35例同期体检健康者作为对照组。分析促甲状腺激素(thyroid stimulating hormone,TSH)、游离三碘甲状腺原氨酸(triiodothyronine,FT3)、游离甲状腺素(free thyroxine, FT4)及甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPO-Ab),MCP-1及CD195水平,甲状腺峡部厚径及甲状腺上动脉收缩期峰值流速(peak systolic velocity,PSV)的变化与HT的相关性。采用流式细胞仪分析CD195阳性细胞百分比,采用酶联免疫吸附法检测血清MCP-1水平,采用彩色超声诊断仪分析甲状腺峡部厚径及PSV。结果 在对照组、 正常组和甲减组中,MCP-1(pg/ml)水平和CD195阳性细胞百分比(%)分别为17.19±3.27,25.38±4.18,38.23±4.97和13.27±3.52,19.39±5.12, 31.20±8.67。甲减组和正常组的MCP-1水平和CD195阳性细胞百分比均高于对照组,其中甲减组的MCP-1水平和CD195阳性细胞百分比增高更显著(F=58.67～62.19,均P=0.000)。在对照组、正常组和甲减组中,PSV(cm/s)及峡部厚径(cm)分别为29.39±8.77,32.50±9.21,53.12±11.37和0.26±0.05,0.39±0.08,0.52±0.10,甲减组和正常组的峡部厚径及PSV均高于对照组,其中甲减组的峡部厚径和PSV增高更显著(F=25.64～37.36,均P=0.000)。相关性分析显示,甲减组和正常组的MCP-1水平和CD195阳性细胞百分比分别呈正相关性(r=0.835,0.819,均P<0.01)。在甲减组中,MCP-1水平和CD195阳性细胞百分比分别与TSH,TPO-Ab,PSV及峡部厚径呈正相关性,而与FT3和FT4水平呈负相关性(rMCP-1=0.827,0.798,0.809,0.772,-0.789和-0.821,均P<0.01; rCD195=0.813,0.803,0.791,0.783,-0.807和-0.843,P均<0.01)。在正常组中,MCP-1水平和CD195阳性细胞百分比分别与TPO-Ab,PSV及峡部厚径呈正相关性(rMCP-1=0.772,0.813和0.805,均P<0.01; rCD195=0.763,0.799和0.817,均P<0.01)。结论 分析外周血液MCP-1和CD195水平的变化与HT的相关性,进而为HT的治疗提供更多的依据.

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备注/Memo

备注/Memo:
作者简介:茹平(1984-),男,本科,主管检验师,研究方向:甲状腺疾病的诊断,E-mail:3383418063@qq.com。通讯作者:黄刚(1979-),男,大学本科,主管检验师,研究方向:甲状腺疾病的诊断,E-mail:3436309161@qq.com。收稿日期:2019-11-10 修回日期:2019-12-18
更新日期/Last Update: 2020-03-30