[1]董璐艳,李 锋,袁 笑,等.宁夏回族自治区正常人群四项肝功能项目通用参考区间的调查研究[J].现代检验医学杂志,2020,35(01):115-119.[doi:10.3969/j.issn.1671-7414.2020.01.030]
　DONG Lu-yan,LI Feng,YUAN Xiao,et al.Investigation on the Common Reference Intervals of Four Liver Function Tests of Normal Population in Ningxia Hui Autonomous Region[J].Journal of Modern Laboratory Medicine,2020,35(01):115-119.[doi:10.3969/j.issn.1671-7414.2020.01.030]
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宁夏回族自治区正常人群四项肝功能项目通用参考区间的调查研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
115-119
栏目:
研究简报·实验技术
出版日期:
2020-02-29

文章信息/Info

Title:
Investigation on the Common Reference Intervals of Four Liver Function Tests of Normal Population in Ningxia Hui Autonomous Region
文章编号:
1671-7414(2020)01-115-05
作者:
董璐艳1; 李 锋2; 袁 笑1; 白 玉1;  杨 萍2; 彭新国1
(1.滨州医学院附属医院检验科,山东滨州 256600; 2.宁夏医科大学总医院医学实验中心,银川 750004)
Author(s):
DONG Lu-yan1; LI Feng2; YUAN Xiao1; BAI Yu1; YANG Ping2; PENG Xin-guo2 ( 1.Department of Clinical Laboratory; Affiliated Hospital of Binzhou Medical University; Shangdong Binzhou 256600;  China; 2
( 1.Department of Clinical Laboratory,Affiliated Hospital of Binzhou Medical University,Shangdong Binzhou 256600, China; 2.Department of Clinical Laboratory,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
关键词:
正常人群;  宁夏回族自治区;  肝功能;  参考区间
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2020.01.030
文献标志码:
A
摘要:
目的 探索宁夏回族自治区建立四项肝功能项目通用参考区间(RI)的可行性。方法 收集2015年10月～2016年12月宁夏回族自治区六家医院体检人群包括该研究中四项肝功能[总蛋白(TP)、清蛋白(ALB)、丙氨酸氨基转移酶(ALT)和天门冬氨酸转移酶(AST)]结果在内的相关体检数据。确定参考人群,采用三级嵌套方差分析(3-Level Nested ANOVA)确定是否需要分组,最终使用非参数法建立该地区RI。比较新建与现用RI及其他多中心研究结果的差异。结果 TP的SDR-地区、SDR-性别、SDR-年龄分别是0.25,0.01和0.07; ALB的SDR-地区、SDR-性别、SDR-年龄分别是0.18,0.26和0.27; TP及ALB在地区、年龄及性别间差异无统计学意义(均SDR <0.3)。ALT的SDR-地区、SDR-性别、SDR-年龄分别是0.31,0.44和0.03; AST的SDR-地区、SDR-性别、SDR-年龄分别是0.34,0.31和0.25,ALT及AST在地区及性别间差异有统计学意义(SDR均>0.3)。除银川市外,其余五地ALT,AST的新建与现用RI及其他多中心研究结果存在一定的差异(上、下限差异>10% )。结论 可在该地区建立TP,ALB的通用RI,但需进一步验证; 因ALT,AST存在地域差异,需分组建立RI。某些地区ALT,AST的新建与现用RI不一致,需对其现用RI进行验证。
Abstract:
Objective The purpose of this study was to explore the feasibility of establishing common reference intervals for four liver function tests in Ningxia Hui Autonomous Region using data from the physical examination population.Methods Collected the physical examination data of six hospitals in Ningxia Hui Autonomous Region including 4 liver functions [total protein(TP), albumin(ALB), alanine aminotransferase in this study(ALT), and aspartate transferase(AST)] from October 2015 to December 2016.Identify the reference population,and applied a 3-level nested ANOVA to determine if grouping is required,the reference intervals in this region were established using nonparametric method Finally.Compared the differences between the new and current reference intervals and other multicenter studies.Results The SDR-region, SDR-gender and SDR-age of TP were 0.25, 0.01 and 0.07 respectively, the SDR-region, SDR-gender, and SDR-age of ALB were 0.18, 0.26 and 0.27, respectively. There was no statistic difference between region,age and gender in TP and ALB(SDRs were all<0.3). The SDR-region, SDR-sex and SDR-age of ALT were 0.31, 0.44 and 0.03 respectively, the SDR-region, SDR-sex, and SDR-age of AST were 0.34, 0.31 and 0.25, respectively.Significant differences between region and gender were observed in ALT and AST(SDRs were all>0.3 ).There were some differences between the new and current reference intervals and other multi-center research results of ALT and AST in the other five places except Yinchuan(the differences between lower limits or upper limits was more than 10%). Conclusion Common reference intervals of TP and ALB can be established in this region,but further verification is needed.Due to regional differences in ALT and AST, RI needs to be established in groups.In some areas, the new and current reference intervals of ALT and AST are inconsistent, and further verification of the current reference intervals is required.

参考文献/References:

[1] LA'ULU S L, ROBERTS W L. Second-trimester reference intervals for thyroid tests: the role of ethnicity[J]. Clinical Chemistry, 2007, 53(9): 1658-1664.
[2] 李婷婷,赵海建,王薇,等.京津冀地区56家临床检验结果互认实验室18个常规化学项目参考区间结果分析[J].现代检验医学杂志,2017,32(6):154-159. LI Tingting,ZHAO Haijian,WANG Wei,et al. Analysis of reference intervals of 18 routine biochemistry in 56 mutual recognition laboratories in Beijing-Tianjing-Hebei Region [J].J Mod Lab Med,2017, 32(6):154-159.
[3] ICHIHARA K. Statistical considerations for harmonization of the global multicenter study on reference values[J]. Clinica Chimica Acta, 2014, 432(6): 108-118.
[4] ICHIHARA K, BOYD J C, IFCC Committee on Reference Intervals and Decision Limits(C-RIDL). An appraisal of statistical procedures used in derivation of reference intervals[J]. Clinical Chemistry and Laboratory Medicine, 2010, 48(11): 1537-1551.
[5] BAKAN E, POLAT H, OZARDA Y, et al. A reference interval study for common biochemical analytes inEastern Turkey:a comparison of a reference population with laboratory datamining[J]. Biochemia Medica, 2016, 26(2): 210-223.
[6] 鲁彦,岳建云,李德红,等.间接法建立亚高原地区成年人血清甲状腺激素生物参考区间[J].国际检验医学杂志,2018,39(22):2832-2835,2841. LU Yan,YUE Jianyun,LI Dehong,et al.To establish reference interval for serum thyroid hormone in adults of subaltitude determined by indirect method[J].Int J Lab Med, 2018,39(22):2832-2835,2841.
[7] 郭玮,宋斌斌,沈隽霏,等.基于实验室数据信息库建立丙氨酸转氨酶生物参考区间[J].中华医学杂志,2015,95(32):2599-2602. GUO Wei,SONG Binbin,SHEN Junfei,et al. Establishing biological reference intervals of alanine transaminase for clinical laboratory stored database [J].Natl Med J China, 2015, 95(32):2599- 2602.
[8] 沈宇欢,夏骏.运用间接法建立杭州地区血清钾,钠,氯,钙,镁,磷的参考区间[J].中国卫生检验杂志,2018,28(20):2475-2478. SHEN Yuhuan,XIA Jun. Establishing of the reference intervals of serum K, Na, Cl, Ca, Mg and P in Hangzhou by indirect method [J]. Chinese Journal of Health Laboratory Technology,2018, 28(20):2475-2478
[9] MU Runqing, CHEN Wenxiang, PAN Baishen, et al. First definition of reference intervals of liver function tests in China: a large-population-based multi-center study about healthy adults[J]. PLoS One, 2013, 8(9): e72916.
[10] 朱月平,陈显秋,陈倩倩,等.长春地区白蛋白参考区间适用性验证探讨[J].中国实验诊断学,2016,20(7):1118-1120. ZHU Yueping,CHEN Xianqiu,CHEN Qianqian,et al.Discussion on applicability verification of albumin reference interval in Changchun[J]. Chinese Journal of Laboratory Diagnosis,2016, 20(7):1118-1120.
[11] 徐华,陈佳,梁英杰,等.盘锦地区ALT参考区间的建立以及血脂(TG,TC)对ALT的影响[J].中国现代医生,2017,55(17):112-115. XU Hua,CHEN Jia,LIANG Yingjie, et al. The establishment of ALT reference interval and the effect of blood lipid(TG, TC)on ALT in Panjin area [J].China Mordern Doctor,2017,55(17):112-115.
[12] RUHL C E, EVERHART J E. Upper limits of normal for alanine aminotransferase activity in the United States population[J]. Hepatology(Baltimore, Md.), 2012, 55(2): 447-454.
[13] XIA Liangyu, CHEN Ming, LIU Min, et al. Nationwide multicenter reference interval study for 28 common biochemical analytes in China[J]. Medicine, 2016, 95(9): e2915.
[14] OZARDA Y, ICHIHARA K, ASLAN D, et al. A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers[J]. Clinical Chemistry and Laboratory Medicine, 2014, 52(12): 1823-1833.

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备注/Memo

备注/Memo:
基金项目:宁夏地区基层医院检验科卫生服务现状研究(2016003)。 作者简介:董璐艳(1984-),女,硕士学位,主管技师,主要研究方向为实验室管理,E-mail:124571043@qq.com。 通讯作者:彭新国(1971-),男,研究生,副主任技师,研究方向为实验室管理,E-mail:bzyfxxyl@126.com。收稿日期:2019-08-18 修回日期:2020-01-01
更新日期/Last Update: 2020-03-30