[1]左二冬,代 卫,陆 晔,等.放疗相关性贫血患者血清Hepcidin,EPO 表达特征[J].现代检验医学杂志,2020,35(02):43-45.[doi:10.3969/j.issn.1671-7414.2020.02.013]
 ZUO Er-dong,DAI Wei,LU Ye,et al.Expression Features of Serum Hepcidin and EPO in Tumor Patients withRadiotherapy-Related Anemia[J].Journal of Modern Laboratory Medicine,2020,35(02):43-45.[doi:10.3969/j.issn.1671-7414.2020.02.013]
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放疗相关性贫血患者血清Hepcidin,EPO 表达特征()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
43-45
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Expression Features of Serum Hepcidin and EPO in Tumor Patients withRadiotherapy-Related Anemia
文章编号:
1671-7414(2020)02-043-03
作者:
左二冬代 卫陆 晔程 旭潘湘涛
( 苏州大学附属太仓医院,江苏太仓 215400)
Author(s):
ZUO Er-dong DAI Wei LU Ye CHENG Xu PAN Xiang-tao
(Taicang Hospital of Suzhou University,Jiangsu Taicang 215400, China)
关键词:
放疗贫血铁调素促红细胞生成素发病机制肿瘤
分类号:
R556;R392.11
DOI:
10.3969/j.issn.1671-7414.2020.02.013
文献标志码:
A
摘要:
目的 研究放疗相关性贫血患者血清铁调素(Hepcidin,Hep)和促红细胞生成素(EPO)表达特征及其意义。方法 对接受放疗的92 例肿瘤患者和20 例对照组测定血红蛋白(Hb),并应用双抗夹心生物素- 亲和素- 酶联免疫吸附试验方法检测Hep 和EPO,并分析其相关关系和临床意义。结果 ① 92 例患者在放疗前和放疗后以及20 例对照组的Hb 水平分别为127.33±17.12,119.41±17.05 和132.80±11.80g/L,差异有统计学意义(F=11.70,P<0.01)。放疗前后实际贫血例数分别为14 例和27 例(χ2=8.68,P<0.01)。②放疗前、放疗后和对照组的Hep 分别为3.38±2.4,2.37±1.37和3.22±1.10mg/ml,差异有统计学意义(F=3.88,P< 0.05)。③放疗前、放疗后和对照组EPO分别为5.05±3.50,5.75±1.99和3.81±1.15mg/ml,差异有统计学意义(F=9.18,P < 0.01)。④放疗前Hepcidin 与Hb 呈负相关关系(r=-0.293 8,t=2.908 9,P<0.01),而放疗后Hep 与Hb 无相关性(r= -0.011 1,P > 0.05)。⑤放疗前和放疗后的EPO 与Hep 之间均无相关性(r=0.123 4,0.035 5,均P > 0.05)。结论 放疗可以引起肿瘤患者发生贫血。贫血负反馈抑制Hepcidin的表达,同时EPO 代偿性高表达。Hep 与EPO 无相关性。

参考文献/References:

[1] NEMETH E, GANZ T. Anemia of inflammation[J].Hematology-Oncology Clinics of North America, 2014,28(4): 671-681, vi.
[2] SASU B J, LI Hongyan, ROSE M J, et al. Serum hepcidinbut not prohepcidin may be an effective marker for anemiaof inflammation (AI)[J]. Blood Cells Molecules andDiseases, 2010, 45(3): 238-245.
[3] GANZ T, OLBINA G, GIRELLI D, et al. Immunoassayfor human serum hepcidin[J]. Blood, 2008, 112(10):4292-4297.
[4] KWON H Y, KIM B R, KIM Y W. Association ofpreoperative anemia and perioperative allogenicred blood cell transfusion with oncologic outcomesin patients with nonmetastatic colorectal cancer[J].Current Oncology, 2019, 26(3): e357-e366.
[5] 赵灵琴,张英丽,方晨燕,等.宫颈癌放化疗患者贫血及其治疗现状的调查研究[J].中国现代医生,2019,57(16):131-135.   ZHAO Lingqin, ZHANG Yingli, FANG Chenyan,et al. Investigation on anemia and its treatmentstatus in patients with cervical cancer undergoingradiotherapy and chemotherapy [J]. Modern ChineseMedicine,2019,57(16):131-135.
[6] WANG Yong, PROBIN V, ZHOU Daohong. Cancertherapy-induced residual bone marrow injurymechanismsof induction and implication for therapy[J].Current Cancer Therapy Reviews, 2006, 2(3): 271-279.
[7] FUKUDA H, TAKEKUMA M, HIRASHIMA Y.Vitamin B12 deficiency anemia and polyneuropathydue to chronic radiation enteritis[J]. Internal Medicine ,2019, 11(18): 3695-3699.
[8] 潘湘涛,陆晔,程旭,等.癌症患者血清Hepcidin及炎症介质细胞因子表达特点及其与贫血的关系[J]. 现代检验医学杂志,2011,26(4):22-24, 27.   PAN Xiangtao,LU Ye,CHENG Xu,et al. Expressioncharacters of serum Hepcidin,inflammatory mediatorsand cytokines in patients with cancer and the relationsbetween anemia and them [J].Journal of ModernLabortory Medicine, 2011,26(4):22-24, 27.
[9] BHAT K, SANDLER K, DUHACHEK-MUGGY S, etal. Serum erythropoietin levels, breast cancer and breastcancer-initiating cells[J]. Breast Cancer Research, 2019,21(1): 17.
[10] 陆晔,程旭,王金湖,等.IDA 患者血清铁调素、铁幼素、膜铁转运蛋白和转铁蛋白受体2 的表达特点及意义[J].现代检验医学杂志,2013,28(3):24-26.   LU Ye, CHENG Xu, WANG Jinhu, et al. Expressionfeature and significance of Hepcidin,Hemojuvelin,Ferroportin and TFR2 in patients with irondeficiency anemia[J].Journal of Modern LabortoryMedicine,2013,28(3):24-26.
[11] LU Ye, CHENG Xu, LI Rong, et al. The expressionand clinical significance of ferroportin and hepcidinin breast cancer patients[J]. The Journal of the KuwaitMedical Association, 2016, 48(4): 323-327.

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备注/Memo

备注/Memo:
作者简介:左二冬(1981-),男,硕士,副主任医师,主要从事肿瘤放疗的基础与临床研究。通讯作者:潘湘涛,E-mail:panxiangtao@csco.ac.cn。收稿日期:2019-11-26修回日期:2020-01-02
更新日期/Last Update: 2020-04-30