[1]侯 娟,蒋树立,滕长财.基于TCGA 数据库卵巢癌患者的miR-301b 表达量与生存状况生物信息学分析[J].现代检验医学杂志,2020,35(04):37-40.[doi:10.3969/j.issn.1671-7414.2020.04.009]
 HOU Juan,JIANG Shu-li,TENG Chang-cai.Bioinformatics Analysis of Mir-301b Expression and Survival Status of Patients with Ovarian Cancer Based on TCGA Database[J].Journal of Modern Laboratory Medicine,2020,35(04):37-40.[doi:10.3969/j.issn.1671-7414.2020.04.009]
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基于TCGA 数据库卵巢癌患者的miR-301b 表达量与生存状况生物信息学分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
37-40
栏目:
论 著
出版日期:
2020-09-05

文章信息/Info

Title:
Bioinformatics Analysis of Mir-301b Expression and Survival Status of Patients with Ovarian Cancer Based on TCGA Database
文章编号:
1671-7414(2020)04-037-04
作者:
侯 娟蒋树立滕长财
(滨州医学院附属医院,山东滨州 256603)
Author(s):
HOU JuanJIANG Shu-liTENG Chang-cai
(the Affiliated Hospital of Binzhou Medical College, Shandong Binzhou 256603, China)
关键词:
卵巢癌miR-301b抑癌因子 肿瘤基因图谱数据库
分类号:
R737.31;R730.43
DOI:
10.3969/j.issn.1671-7414.2020.04.009
文献标志码:
A
摘要:
目的 研究肿瘤基因图谱(the cancer genome atlas,TCGA)数据库中microRNA-301b(miR-301b)在478 例卵巢癌患者中的表达量与卵巢癌患者生存状况的关系。方法 对TCGA 数据库中478 例卵巢癌患者的miR-301b 表达量与生存状况进行分析,预测其靶基因及生物学活性。结果 miR-301b 高表达患者具有更长的生存时间, 是卵巢癌患者预后的保护因素(OS:P<0.001, DFS:P<0.05),综合3 个靶基因数据库的预测结果得到12 个靶基因,编码的蛋白多数与肿瘤的发生发展有关,其中靶基因TEA 结构域家族成员1(TEA domain family member 1,TEAD1) 与胞质多糖基化元件结合蛋白4(cytoplasmic polyadenylation element binding protein 4, CPEB4)的表达量与卵巢癌患者的预后相关(TEAD1:P<0.05,CPEB4:P<0.05)。结论 miR-301b 表达对卵巢癌患者的预后具有重要的意义,表现出抑癌因子的作用,对卵巢癌的预后评估和治疗具有重要的指导意义。

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备注/Memo

备注/Memo:
收稿日期:2020-04-05 修回日期:2020-05-07基金项目:滨州医学院科技计划项目(BY2017KJ02)。作者简介:侯娟(1990-),女,本科,初级检验师,研究方向:肿瘤分子生物学,E-mail:1244568188@qq.com。
更新日期/Last Update: 2020-10-08