[1]吕亚玲.血清GLU 和尿液mALB 水平检测对白内障发生的预测价值评价[J].现代检验医学杂志,2020,35(04):154-157.[doi:10.3969/j.issn.1671-7414.2020.04.039]
 L? Ya-ling.Evaluation of Predictive Value of Serum GLU and Urine mALB Levels in Cataract Development[J].Journal of Modern Laboratory Medicine,2020,35(04):154-157.[doi:10.3969/j.issn.1671-7414.2020.04.039]
点击复制

血清GLU 和尿液mALB 水平检测对白内障发生的预测价值评价()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
154-157
栏目:
检验与临床
出版日期:
2020-09-05

文章信息/Info

Title:
Evaluation of Predictive Value of Serum GLU and Urine mALB Levels in Cataract Development
文章编号:
1671-7414(2020)04-154-04
作者:
吕亚玲
(南京宁益眼科中心,南京 210000)
Author(s):
L? Ya-ling
(Ningyi Ophthalmic Center of Nanjing, Nanjing 210000, China)
关键词:
白内障尿微量清蛋白血葡萄糖Logistic 回归
分类号:
R776.1;R446
DOI:
10.3969/j.issn.1671-7414.2020.04.039
文献标志码:
A
摘要:
目的 采用Logistic 回归及受试者工作特征(ROC)曲线综合评价实验室常规检测项目对白内障发生的预测价值。方法 收集2018 年1~12 月于南京宁益眼科中心就诊的50 例白内障患者及同期50 例非白内障患者,检测分析实验室常规检测项目尿素(BUN)、肌酐(CREA)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride ,TG)、血糖(GLU)、纤维蛋白原(fibrinogen, FIB)、活化部分凝血活酶时间(APTT)、超敏C 反应蛋白(hs-CRP)和尿微量清蛋白(mALB)的水平,对有统计学意义的指标, 先采用多因素Logistic 回归模型分析,再进行ROC 分析模型的预测价值。结果 ①白内障患者组GLU 及mALB 均高于非白内障组,差异具有统计学意义(t=3.68, P=0.000; t=2.06,P=0.042)。② Logistic回归分析,GLU (OR=2.532, 95% CI:1.224~5.237) 和 mALB (OR=1.155, 95% CI:1.070~1.247) 与白内障发生发展存在相关性(P<0.05)。据此构建的白内障发生的风险预测模型为Y=1/[1+e- (0.929X1+0.144X2-7.852) ]。③两者联合诊断白内障的ROC曲线下面积(AUC)大于GLU 和mALB 单项检测的AUC。结论 GLU 和mALB 与白内障疾病发生发展显著相关, 白内障风险预测模型有一定的预测价值。

参考文献/References:

[1] LEE C M, AFSHARI N A. The global state of cataractblindness[J]. Current Opinion in Ophthalmology, 2017,28(1): 98-103.
[2] 姚克.我国白内障研究发展方向及面临的问题[J].中华眼科杂志,2015, 51(4): 241-244. YAO Ke. Cataract in China: research and developmentdirection and problems encountered[J]. Chinese Journalof Ophthalmology, 2015, 51(4): 241-244.
[3] ALIMAW Y A, HUSSEN M S, TEFERA T K, et al.Knowledge about cataract and associated factors amongadults in gondar town, northwest ethiopia [J]. PLoSOne, 2019, 14(4): e02158094.
[4] 张小梅,杨剑锋.长沙市老年性白内障患病率及其影响因素分析[J].湖南师范大学学报(医学版),2015, 12(2): 40-43. ZHANG Xiaomei,YANG Jianfeng. Analysis on theprevalence and influence factors of senile cataractof Changsha City[J]. Journal of Hunan NormalUniversity(Medical Sciences), 2015, 12(2): 40-43.
[5] 徐莉,孙堂胜.白内障发生的相关影响因素[J].中国当代医药, 2018, 25(34): 19-22. XU Li, SUN Tangsheng. Related influence factors ofthe occurrence of cataract[J]. China Modern Medicine,2018, 25(34): 19-22.
[6] 汪怿,徐洁慧,杨杰,等.中老年白内障患者凝血功能与血液流变学变化分析[J].中国卫生检验杂志,2018, 28(11): 1358-1359, 1364. WANG Yi, XU Jiehui, YANG Jie, et al. Changes andanalysis of coagulation function and hemorheologyin middle-aged and elderly patients with cataract[J].Chinese Journal of Health Laboratory Technology,2018, 28(11): 1358-1359, 1364.
[7] 李圣杰,邵明希,吉建,等.中老年白内障患者临床生化指标的相关性分析[J].中华检验医学杂志,2016, 39(6): 448-453. LI Shengjie, SHAO Mingxi, JI Jian, et al. Thecorrelation analysis between clinical biochemicalindexes and cataract of middle aged and senior [J].Chinese Journal of Laboratory Medicine, 2016, 39(6):448-453.
[8] 许戎. 糖尿病肾病生物学标记物新进展[J].中华检验医学杂志, 2015, 38(9): 583-585. XU Rong. Recent progress of biomarkers for diabetickidney disease [J]. Chinese Journal of LaboratoryMedicine, 2015,38 (9): 583-585.
[9] 卫冬,穆寅东.高血压合并白内障患者血脂水平分析[J].中华心脏与心律杂志(电子版),2019,7(2):102-103. WEI Dong, MU Yindong. Analysis of blood lipidlevels in patients with hypertension complicatedwith cataract[J]. Chinese Journal of Heart and HeartRhythm(Electronic Edition) ,2019, 7(2): 102-103.
[10] 苏洋,梅秋雁.血浆NGAL,Cys C 和尿NAG/Crea联合检测对早期糖尿病肾病诊断价值的研究[J].现代检验医学杂志,2018, 33(1): 99-101, 105. SU Yang, MEI Qiuyan. Study on combined determinationplasma NGAL,Cys C and urinary NAG/Crea for the diagnosisof early diabetic nephropathy [J].Journal of ModernLaboratory Medicine, 2018, 33(1): 99-101, 105.

相似文献/References:

[1]张杰良,邓文成,梁映亮,等.尿微量清蛋白(mALB)五种非线性校准方法研究及测量偏倚分析[J].现代检验医学杂志,2015,30(06):101.[doi:10.3969/j.issn.1671-7414.2015.06.030]
 ZHANG Jie-liang,DENG Wen-cheng,LIANG Ying-liang,et al.Research of Five Nonlinear Calibration Methods and Analysis of Measurement Bias of Urine Microalbumin[J].Journal of Modern Laboratory Medicine,2015,30(04):101.[doi:10.3969/j.issn.1671-7414.2015.06.030]
[2]霍豆,秦爽,邢瑞青,等.西安地区健康成人尿液mAlb, Cr 水平以及mAlb/Cr 比值参考区间的建立[J].现代检验医学杂志,2020,35(05):118.[doi:10.3969/j.issn.1671-7414.2020.05.030]
 HUO Dou,QIN Shuang,XING Rui-qing,et al.Establishment of Reference Interval for UmAlb,Ucr and UmAlb/ UCr in Healthy Adults in Xi’an Area[J].Journal of Modern Laboratory Medicine,2020,35(04):118.[doi:10.3969/j.issn.1671-7414.2020.05.030]
[3]段金利.原发性高血压并发肾病患者尿微量清蛋白 / 尿肌酐比值与心率变异性的相关性研究[J].现代检验医学杂志,2021,36(03):122.[doi:10.3969/j.issn.1671-7414.2021.03.028]
 DUAN Jin-li.Study on the Correlation between Heart Rate Variability and UrinaryMicroalbumin/Urinary Creatinine Ratio in Patients with EssentialHypertension and Kidney Disease[J].Journal of Modern Laboratory Medicine,2021,36(04):122.[doi:10.3969/j.issn.1671-7414.2021.03.028]

备注/Memo

备注/Memo:
收稿日期:2020-01-08修回日期:2020-04-15作者简介:吕亚玲(1973-),女,本科,主管技师,主要从事临床生物化学检验,E-mail:514729372@qq.com。
更新日期/Last Update: 2020-10-08