[1]霍豆,秦爽,邢瑞青,等.西安地区健康成人尿液mAlb, Cr 水平以及mAlb/Cr 比值参考区间的建立[J].现代检验医学杂志,2020,35(05):118-120,163.[doi:10.3969/j.issn.1671-7414.2020.05.030]
　HUO Dou,QIN Shuang,XING Rui-qing,et al.Establishment of Reference Interval for UmAlb,Ucr and UmAlb/ UCr in Healthy Adults in Xi’an Area[J].Journal of Modern Laboratory Medicine,2020,35(05):118-120,163.[doi:10.3969/j.issn.1671-7414.2020.05.030]
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西安地区健康成人尿液mAlb, Cr 水平以及mAlb/Cr 比值参考区间的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
118-120,163
栏目:
研究简报·实验技术
出版日期:
2020-11-01

文章信息/Info

Title:
Establishment of Reference Interval for UmAlb,Ucr and UmAlb/ UCr in Healthy Adults in Xi’an Area
文章编号:
1671-7414（2020）05-118-04
作者:
霍豆; 秦爽; 邢瑞青; 刘杨; 陈健康; 彭道荣; 赵茜
空军军医大学第一附属医院临床检验研究所，西安 710032
Author(s):
HUO Dou; QIN Shuang; XING Rui-qing; LIU Yang; CHEN Jian-kang; PENG Dao-rong; ZHAO Qian
Research Institute of Clinical Laboratory Medicine, the First Affiliated Hospital of the Air Force Medical University, Xi’an 710032, China
关键词:
健康成人; 尿微量清蛋白; 尿肌酐; 参考区间
分类号:
R446.12
DOI:
10.3969/j.issn.1671-7414.2020.05.030
文献标志码:
A
摘要:
目的　建立西安地区健康成人尿微量清蛋白（urine microalbumin，UmAlb），尿肌酐（urine creatinine， Ucr）以及尿微量清蛋白/ 尿肌酐比值（urinary microalbumin /urinary creatinine ratio，UACR）的参考区间。方法　依据 NCCLS C28-A2 推荐方法，收集2019 年5 ~ 10 月来空军军医大学第一附属医院体检的1 388 例健康成人进行UmAlb 和 Ucr 水平检测，其中男性651 人，女性737 人，通过问卷调查和体格检查排除内分泌系统、心血管系统、炎症、肿瘤等 疾病。UmAlb 检测采用散射比浊法，Ucr 检测采用透射比浊法，按照性别、年龄分组（分为6 个年龄组：20~29 岁， 30~39 岁，40~49 岁，50~59 岁，60~69 岁和≥ 70 岁），并对检测结果进行统计分析。结果　西安地区健康成人不同性 别比较，UmAlb 差异不具有统计学意义（Z= -1.405，P>0.05），Ucr 及UACR 差异均具有统计学意义（Z= -10.627， -7.503 ， 均P ＜ 0.05）。不同年龄组两两比较，UmAlb：20~49 岁各组与≥ 50 岁各组，50~69 岁各组与≥ 70 岁组差 异均具有统计学意义（均P ＜ 0.05）；Ucr：20~39 岁各组与≥ 40 岁各组差异均具有统计学意义（均P ＜ 0.05）； UACR：各个年龄组间两两比较差异均具有统计学意义（均P ＜ 0.05）。且随着年龄的增长UmAlb 有上升趋势，Ucr 有下降趋势，UACR 有上升趋势。结论　各实验室应按不同年龄和不同性别建立适合该地区人群UmAlb，Ucr 以及 UACR 的参考区间。
Abstract:
Objective　To establish reference intervals of urine microalbumin（UmAlb）, urine creatinine （Ucr）and urine microalbumin / urine creatinine ratio（UACR）for healthy adults in Xi’an Areas. Methods　According to the guidelines of NCCLS C28-A2 , the UmAlb and Ucr levels of 1 388 healthy adults examined in the First Affiliated Hospital of the Air Force Medical University from May to October 2019 were detected with 651 males and 737 females. Endocrine system, cardiovascular system, inflammation, tumor and other diseases were excluded through questionnaire survey and physical examination. UmAlb was detected by nephelometry while Ucr was detected by turbidimetry. There were classified according to gender and age (divided into 6 age groups： 20~29 years, 30~39 years, 40~49 years, 50~59 years, 60~69 years and ≥ 70 years). The results were statistically analyzed the urine microalbumin were detected by nephelometry and the urine creatinine were detected by turbidimetry. Results　There was no difference in urine microalbumin between different genders（Z= -1.405，P>0.05）. The urine creatinine and UACR levels of healthy adults in Xi’an area were significantly different between different genders and microalbumin （Z= -10.627，-7.503，all P ＜ 0.05）. In different age groups, the levels of urine microalbumin were significantly different between 20~49 age groups and 50~69 age groups， 20~69 age groups and ≥ 70 groups（P ＜ 0.05）. Urine creatinine was different between 20~39 age groups and ≥ 40 age groups（P ＜ 0.05）, and UACR was different among different age groups.With the increase of age, UmAlb had an upaward trend, UCR had a downward trend and UACR had an upward trend. Conclusion　Each laboratory should establish reference intervals for UmAlb, Ucr and UACR of the local population according to different ages and sexes.

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备注/Memo

备注/Memo:
作者简介：霍豆 (1989-)，女，本科，技师，主要从事临床免疫学检验工作，E-mail ：huodou1@163.com。
通讯作者：赵茜（1987-），女，本科，技师，主要从事临床免疫学检验及临床相关疾病的研究工作，E-mail:690092966@qq.com。
更新日期/Last Update: 2020-10-30