[1]肖武强,徐敏丹,吴先正.脓毒症患者血清肠型脂肪酸结合蛋白、二胺氧化酶水平检测对早期肠组织损伤及预后的评估价值[J].现代检验医学杂志,2021,36(01):10-13.[doi:10.3969/j.issn.1671-7414.2021.01.003]
 XIAO Wu-qiang,XU Min-dan,WU Xian-zheng.Evaluation Value of Serum Intestinal Fatty Acid Binding Protein and Diamine Oxidase in the Early Stage of Intestinal Tissue Injury and Prognosis in Patients with Sepsis[J].Journal of Modern Laboratory Medicine,2021,36(01):10-13.[doi:10.3969/j.issn.1671-7414.2021.01.003]
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脓毒症患者血清肠型脂肪酸结合蛋白、二胺氧化酶水平检测对早期肠组织损伤及预后的评估价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
10-13
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Evaluation Value of Serum Intestinal Fatty Acid Binding Protein and Diamine Oxidase in the Early Stage of Intestinal Tissue Injury and Prognosis in Patients with Sepsis
文章编号:
1671-7414(2021)01-010-05
作者:
肖武强徐敏丹吴先正
(同济大学附属同济医院急诊医学科 , 上海 200065)
Author(s):
XIAO Wu-qiang XU Min-dan WU Xian-zheng
(Department of Emergency Medicine, Tongji Hospital Affiliated to Tongji University, Shanghai 200065,China)
关键词:
脓毒症肠组织损伤肠型脂肪酸结合蛋白二胺氧化酶
分类号:
R631;R446.112
DOI:
10.3969/j.issn.1671-7414.2021.01.003
文献标志码:
A
摘要:
目的 探讨血清肠型脂肪酸结合蛋白( I-FABP),二胺氧化酶( DAO)对脓毒症患者早期肠组织损伤及预后的评估价值。方法 选择 2019年 4~12月于同济大学附属同济医院急诊科收治的 80例脓毒症患者及 40例同期健康体检者(对照组)。脓毒症患者又根据急性胃肠损伤分级 (AGI)分为非 AGI组(n=35),AGI组(n=45)。根据入院 28天内死亡情况,将患者分为存活组( n=51)与死亡组( n=29)。比较各组患者血清 I-FABP,DAO及其他临床特征,采用 logistic回归分析脓毒症患者 28天内预后的危险因素。结果 与对照组比较,非 AGI组和 AGI组患者 I-FABP(20.28±3.37, 26.15±4.67μg/L vs 17.16±2.44 μg/L),DAO(2.49±0.63, 3.28±0.87mmol/L vs 1.31±0.34 mmol/L)水平升高( F=65.92, 94.24, P<0.05);与非 AGI组比较, AGI组 I-FABP,DAO水平亦显著升高( P<0.05)。I-FABP,DAO与 CRP,D-乳酸呈显著正相关( r=0.415,0.477,0.426和 0.465,均 P<0.05),而与 TNF-α,IL-6无明显相关性( P>0.05)。与存活组比较,死亡组年龄较大, MV时间明显延长, CRP,PCT,APACHE II评分, SOFA评分, AGI评分, I-FABP,DAO显著升高( t=2.27~11.21,均 P<0.05)。多因素 logistic回归分析显示,APACHE II评分( OR=3.13,95%CI:1.67~4.48), AGI分级( OR=2.36,95%CI:1.38~3.49),I-FABP(OR=1.73,95%CI:1.24~2.51),DAO(OR=1.42,95%CI:1.13~1.84)均是 28天内死亡的独立危险因素( χ2=9.37~20.67,均 P<0.05)。结论 脓毒症患者血清 I-FABP和 DAO明显升高,与 CRP和 D-乳酸间有良好相关性,可反映早期肠组织损伤,有效预测脓毒症患者预后。

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备注/Memo

备注/Memo:
基金项目:上海市卫生计生系统重要薄弱学科建设计划项目(编号:2016ZB0204)。
作者简介:肖武强(1983-) ,男,本科,主治医师,研究方向:肠源性脓毒症的诊治,E-mail:wuhanqiang2020@163.com。
通讯作者:吴先正(1962-),男,博士,主任医师,研究方向:脓毒症患者的内分泌系统调节,E-mail:wuxianzheng1962@163.com。
更新日期/Last Update: 2021-02-05