[1]杨 洋,张利侠,田蕊萍,等.血清白介素-2水平表达与卒中后抑郁相关性的Meta分析[J].现代检验医学杂志,2021,36(02):79-84.[doi:doi:10.3969/j.issn.1671-7414.2021.02.019]
 YANG Yang,ZHANG Li-xia,TIAN Rui-ping,et al.Meta Analysis of the Correlation between Serum Interleukin-2 Expression and Post-stroke Depression[J].Journal of Modern Laboratory Medicine,2021,36(02):79-84.[doi:doi:10.3969/j.issn.1671-7414.2021.02.019]
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血清白介素-2水平表达与卒中后抑郁相关性的Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
79-84
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Meta Analysis of the Correlation between Serum Interleukin-2 Expression and Post-stroke Depression
文章编号:
1671-7414(2021)02-079-07
作者:
杨 洋张利侠田蕊萍
(1.西安医学院,西安710068;2.陕西省人民医院检验科,西安710068)
Author(s):
YANG Yang ZHANG Li-xia TIAN Rui-ping et al
(1. Xi’an Medical University,Xi’an 710068,China;2.Department of Clinical Laboratory,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)
关键词:
血清白介素-2卒中后抑郁Meta分析
分类号:
R749.13;R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.019
文献标志码:
A
摘要:
目的 评价血清白介素-2(serum interleukin-2, sIL-2)水平表达与卒中后抑郁(post-stroke depression, PSD)的关系。方法 计算机检索中国生物医学文献(CBM),CNKI,WANFANG,PubMed和Embase等数据库,筛选有关sIL-2与PSD关系的病例对照研究,检索时间均从建库至2020年3月。根据纳入与排除标准,最终纳入9篇文献,共898例样本量,采用Review Manager 5.3软件进行统计学分析。结果 sIL-2的表达在入院次日PSD组与脑梗死恢复期组间[SMD=4.39, 95%CI (3.38, 5.41), P<0.000 01]、入院7天PSD组与脑梗死急性期组间[SMD=-1.68, 95%CI (-2.19, -1.16), P<0.000 01]、入院1月时PSD组与对照组(同期脑梗死组)间[SMD=2.82, 95%CI (0.99, 4.66), P=0.003],以及PSD组中轻度与中度抑郁组间[SMD=1.06, 95%CI (0.35, 1.76), P=0.003]、中度与重度抑郁组间[SMD=0.90, 95%CI (0.19, 1.60), P=0.01]差异均有统计学意义。结论 目前的文献证据表明,sIL-2水平可能在PSD的发病机制中起重要作用,并且随着PSD程度的加重而升高。但还需要更多设计良好的前瞻性研究来进行验证。

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备注/Memo

备注/Memo:
作者简介:杨洋(1992-),女,在读硕士,初级检验医师,研究方向:临床检验诊断,E-mail:1484304693@qq.com。
通讯作者:张利侠,女,主任技师,硕士生导师,E-mail:2541871021@we.com。
更新日期/Last Update: 2021-04-10