[1]李 娟,张芬红,徐卓婧,等.老年急性 ST 段抬高型心肌梗死患者血浆 miR-499-5p 表达水平对并发急性心力衰竭的预测价值[J].现代检验医学杂志,2021,36(03):48-51.[doi:10.3969/j.issn.1671-7414.2021.03.011]
 LI Juana,ZHANG Fen-honga,XU Zhuo-jinga,et al.Predictive Value of Plasma miR-499-5p for Acute Heart Failure afterAcute ST-Elevated Myocardial Infarction in Elderly Patients[J].Journal of Modern Laboratory Medicine,2021,36(03):48-51.[doi:10.3969/j.issn.1671-7414.2021.03.011]
点击复制

老年急性 ST 段抬高型心肌梗死患者血浆 miR-499-5p 表达水平对并发急性心力衰竭的预测价值()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
48-51
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Predictive Value of Plasma miR-499-5p for Acute Heart Failure afterAcute ST-Elevated Myocardial Infarction in Elderly Patients
文章编号:
1671-7414(2021)03-048-05
作者:
李 娟张芬红徐卓婧
(西安市第五医院 a. 心血管二病区;b. 呼吸内科 , 西安 710082)
Author(s):
LI JuanaZHANG Fen-hongaXU Zhuo-jingaZHANG Taob
(a.Cardiovascular Second Ward;b.Department of Respiratory Medicine, Xi’an No. 5 Hospital, Xi’an 710082, China)
关键词:
急性心肌梗死急性心力衰竭微小核糖核酸 -499-5p
分类号:
R542.22;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.03.011
文献标志码:
A
摘要:
目的 探讨老年急性 ST 段抬高型心肌梗死(STEMI)患者血浆微小核糖核酸 -499-5p(miR-499-5p)水平对并发急性心力衰竭(AHF)的预测价值。方法 连续性收集 2019 年 1 月 ~12 月就诊于西安市第五医院的 135 例老年急性STEMI 患者纳入病例组,并根据发病 48h 内是否发生急性心力衰竭(AHF)将病例组分为 AHF 亚组和非 AHF 亚组。另随机选择同期在该院行健康体检的志愿者 50 例为对照组。采用实时荧光定量 PCR(RT-qPCR)法检测血浆 miR-499-5p 的相对表达水平。结果 病例组血浆 miR-499-5p 相对表达水平显著高于对照组(Z=10.434,P < 0.001)。AHF 亚组血浆 miR-499-5p 相对表达水平显著高于非 AHF 亚组(Z=5.817,P < 0.001)。病例组患者血浆 miR-499-5p 相对表达水平与 cTnI,CK-MB,BNP 和 Killip 分级均呈正相关关系(r=0.339,0.243,0.477,0.581,均 P < 0.01)。多因素分析结果显示老年急性 STEMI 患者血浆 miR-499-5p 表达升高是并发 AHF 的独立危险因素(OR=3.192,P=0.011)。血浆miR-499-5p 预测 AHF 的 AUC 为 0.797(0.725,0.869)。结论 老年急性 STEMI 患者血浆 miR-499-5p 表达水平显著升高,可能是并发 AHF 的独立危险因素。

参考文献/References:

[1] SHAH M, PATNAIK S, PATEL B, et al. The day of theweek and acute heart failure admissions: Relationshipwith acute myocardial infarction, 30-day readmissionrate and in-hospital mortality[J]. Int J Cardiol, 2017,249:292-300.
[2] 黄 晖 , 郭玉刚 , 朱伟俊 . 强离子隙对急性心肌梗死致急性心力衰竭的预测作用研究 [J]. 现代检验医学杂志 ,2020,35(4):143-146. HUANG Hui, GUO Yugang, ZHU Weijun. Effect ofstrong ion gap on prediction of acute heart failureinduced by myocardial infarction[J].Journal of ModernLaboratory Medicine,2020,35(4):143-146.
[3] LEE J S, SONG D W, PARK J H, et al. MiR-374promotes myocardial hypertrophy by negativelyregulating vascular endothelial growth factor receptor-1signaling[J]. BMB Rep, 2017, 50(4):208-213.
[4] VIRTUE A, JOHNSON C, LOPEZ-PASTRA?A J,et al. MicroRNA-155 deficiency leads to decreasedatherosclerosis, increased white adipose tissue obesityand nonalcoholic fatty liver disease: a novel mousemodel of obesity paradox[J]. J Biol Chem, 2017,292(4):1267-1287.
[5] ZHOU Rui, HUANG Wenjun, FAN Xinrong, et al.miR-499 released during myocardial infarction causesendothelial injury by targeting α7-nAchR[J]. J CellMol Med, 2019, 23(9): 6085-6097.
[6] PINCHI E, FRATI P, AROMATARIO M, et al. MiR1, miR-499 and miR-208 are sensitive markers todiagnose sudden death due to early acute myocardialinfarction[J]. J Cell Mol Med, 2019, 23(9): 6005-6016.
[7] LI Ping, LI Siyao, LIU Ming, et al. Value of the expression of miR-208, miR-494, miR-499 and miR-1303 inearly diagnosis of acute myocardial infarction[J]. LifeSci, 2019, 232: 116547.
[8] 中华医学会心血管病学分会 , 中华心血管病杂志编辑委员会 . 急性 ST 段抬高型心肌梗死诊断和治疗指南 [J]. 中华心血管病杂志 , 2015, 43(5):380-393. Chinese Society of Cardiology, Editorial Board ofChinese Journal of Cardiovascular Diseases. Guidelinesfor the diagnosis and management of patients with STsegment elevation myocardial infarction[J]. ChineseJournal of Cardiology, 2015, 43(5):380-393.
[9] 中华医学会心血管病学分会 , 中华心血管病杂志编辑委员会 . 中国心力衰竭诊断和治疗指南 2014[J].中华心血管病杂志 , 2014, 42(2):98-122. Chinese Society of Cardiology, Editorial Board of ChineseJournal of Cardiovascular Diseases. Guidelines fordiagnosis and treatment of heart failure in China 2014[J].Chinese Journal of Cardiology, 2014, 42(2):98-122.
[10] KAGIYAMA N, KITAI T, HAYASHIDA A, et al.Prognostic value of bnp reduction during hospitalizationin patients with acute heart failure[J]. J Card Fail, 2019,25(9): 712-721.
[11] 李慧娣 , 向定成 , 张金霞 , 等 . 急性心肌梗死早期脑钠肽浓度的动态演变规律及其对心力衰竭的诊断价值 [J]. 南方医科大学学报 , 2018, 38(1):112-116. LI Huidi, XIANG Dingcheng, ZHANG Jinxia, etal. Dynamic changes of brain natriuretic peptideconcentration and its diagnostic value for heart failurein early phase of acute myocardial infarction[J]. Journalof Southern Medical University, 2018, 38(1):112-116.
[12] 薛剑 , 马明军 , 臧秀敏 , 等 . 甲状腺激素水平对急性心肌梗死后心力衰竭发生的预测价值 [J]. 心肺血管病杂志 , 2017, 36(12):996-998,1003. XUE Jian, MA Mingjun, ZANG Xiumin, et al. Theclinical significance of thyroid hormone to the heartfailure after acute myocardial infarction[J]. Journalof Cardiovascular and Pulmonary Diseases, 2017,36(12):996-998,1003.
[13] GIDL?F O, ANDERSSON P, VAN DER PALS J, etal. Cardiospecific microRNA plasma levels correlatewith troponin and cardiac function in patients withST elevation myocardial infarction, are selectivelydependent on renal elimination, and can be detected inurine samples[J]. Cardiology, 2011, 118(4): 217-226.
[14] 肖蕾 , 沈飞燕 , 洪斌 , 等 . 血液微小 RNA-499 对早期诊断急性心肌梗死价值的Meta分析[J]. 安徽医药,2018, 22(1):50-54. XIAO Lei, SHEN Feiyan, HONG Bin, et al. The valueof microRNA-499 in blood for early diagnosis ofacute myocardial infarction:a Meta-analysis[J]. AnhuiMedical and Pharmaceutical Journal, 2018,22(1):50-54.
[15] 蔡新宇, 程绩, 苏晴, 等. 急性心肌梗死患者microRNA- 499 的表达及临床意义 [J]. 疑难病杂志 , 2018,17(6):541-544. CAI Xinyu, CHENG Ji, SU Qing, et al. Expressionand clinical significance of microRNA-499 in patients with acute myocardial infarction[J]. Chinese Journal ofDifficult and Complicated Cases, 2018, 17(6):541-544.
[16] SHIEH J T C, HUANG Yu, GILMORE J, et al.Elevated miR-499 levels blunt the cardiac stressresponse[J]. PLoS One, 2011, 6(5):e19481.
[17] TIJSEN A J, CREEMERS E E, MOERLAND P D,et al. MiR423-5p as a circulating biomarker for heartfailure[J]. Circ Res, 2010, 106(6): 1035-1039.
[18] CORSTEN M F, DENNERT R, JOCHEMS S, et al.Circulating microRNA-208b and microRNA-499reflect myocardial damage in cardiovascular disease[J]. Circ Cardiovasc Genet, 2010, 3(6): 499-506.

相似文献/References:

[1]宋 倩a,张 雯b.急性心肌梗死患者血浆PCSK9 水平对临床不良事件发生的预测价值分析[J].现代检验医学杂志,2020,35(03):72.[doi:10.3969/j.issn.1671-7414.2020.03.018]
 SONG Qiana,ZHANG Wenb.Analysis of the Predictive Value of Plasma PCSK9 Level on Clinical Adverse Events in Patients with Acute Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2020,35(03):72.[doi:10.3969/j.issn.1671-7414.2020.03.018]
[2]达晶,张超,吴红葵,等.急性心肌梗死患者血浆miRNA-423-5p 与整合素连接激酶水平表达对评价近期临床预后的价值[J].现代检验医学杂志,2020,35(05):33.[doi:10.3969/j.issn.1671-7414.2020.05.009]
 DA Jing,ZHANG Chao,WU Hong-kui,et al.Expression of Plasma miRNA-423-5p and Integrin-linked Kinase Levels in Patients with Acute Myocardial Infarction for Evaluating Recent Clinical Outcomes[J].Journal of Modern Laboratory Medicine,2020,35(03):33.[doi:10.3969/j.issn.1671-7414.2020.05.009]
[3]何 平.急性心力衰竭病人血清 Hcy 与 NA-ProBNP,LP(a) 水平及性别的相关性研究[J].现代检验医学杂志,2020,35(06):176.[doi:doi:10.3969/j.issn.1671-7414.2020.06.043]
 HE Ping.Correlation between Serum Hcy,NA-ProBNP,LP (a) Levels and Gender inPatients with Heart Failure[J].Journal of Modern Laboratory Medicine,2020,35(03):176.[doi:doi:10.3969/j.issn.1671-7414.2020.06.043]
[4]刘 云,孙静芳,马 萍.外周血血细胞参数在急性主动脉夹层与急性心肌梗死鉴别中的价值[J].现代检验医学杂志,2021,36(01):132.[doi:10.3969/j.issn.1671-7414.2021.01.033]
 LIU Yun,SUN Jing-fang,MA Ping.Value of Peripheral Blood Cell Parameters in Differentiating Acute Aortic Dissection from Acutemyocardial Infarction[J].Journal of Modern Laboratory Medicine,2021,36(03):132.[doi:10.3969/j.issn.1671-7414.2021.01.033]
[5]杜春娟,李 丹,王 岑,等.急性心肌梗死并发阿斯综合征患者血清和肽素与 Adropin 水平联合检测的早期诊断价值研究[J].现代检验医学杂志,2021,36(03):97.[doi:10.3969/j.issn.1671-7414.2021.03.022]
 DU Chun-juan,WANG Cen,HUYAN-Li,et al.Study on the Early Diagnostic Value of Serum Copeptin and Adropin Levels in Patients with Acute Myocardial Infarction Complicated with Adams-stokes Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(03):97.[doi:10.3969/j.issn.1671-7414.2021.03.022]
[6]刘 蕾a,赵 鹏b,张 军a,等.急性心肌梗死患者血浆外泌体miR-21-3p/PTEN/AKT 表达水平及诊断价值研究[J].现代检验医学杂志,2022,37(05):118.[doi:10.3969/j.issn.1671-7414.2022.05.023]
 LIU Leia,ZHAO Pengb,ZHANG Juna,et al.Serum Exosomal miR-21-3p/PTEN/AKT Expression and Diagnostic Value in Patients with Acute Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2022,37(03):118.[doi:10.3969/j.issn.1671-7414.2022.05.023]
[7]柴亮听,张 卉,冯 艳,等.急性心肌梗死患者血清miR-423-5P,Bcl-2 和LC3-II 水平表达与预后相关性研究[J].现代检验医学杂志,2023,38(01):117.[doi:10.3969/j.issn.1671-7414.2023.01.022]
 CHAI Liang-ting,ZHANG Hui,FENG Yan,et al.Correlation between Serum of miR-423-5p, Bcl-2 and LC3-II and Prognosis in Patients with Acute Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2023,38(03):117.[doi:10.3969/j.issn.1671-7414.2023.01.022]

备注/Memo

备注/Memo:
作者简介:李娟(1987-),女,硕士,主治医师,研究方向:心内、糖尿病,E-mail:xianlijuan19870513@163.com。
通讯作者:张涛(1980-),男,硕士,主治医师,研究方向:重症呼吸,E-mail:1113003531@qq.com。
更新日期/Last Update: 1900-01-01