[1]贾艳增,时东彦.替加环素与临床常用抗生素对碳青霉烯耐药高毒力肺炎克雷伯菌体外联合药敏试验[J].现代检验医学杂志,2021,36(03):113-117.[doi:10.3969/j.issn.1671-7414.2021.03.026]
 JIA Yan-zeng,SHI Dong-yan.Tigecycline in Combination with Commonly Used Antibiotics AgainstClinicalIsolates of Hypervirulent and Carbapenem-Resistant KlebsiellaPneumoniae in Vitro[J].Journal of Modern Laboratory Medicine,2021,36(03):113-117.[doi:10.3969/j.issn.1671-7414.2021.03.026]
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替加环素与临床常用抗生素对碳青霉烯耐药高毒力肺炎克雷伯菌体外联合药敏试验()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
113-117
栏目:
研究简报·实验技术
出版日期:
2021-05-31

文章信息/Info

Title:
Tigecycline in Combination with Commonly Used Antibiotics AgainstClinicalIsolates of Hypervirulent and Carbapenem-Resistant KlebsiellaPneumoniae in Vitro
文章编号:
1671-7414(2021)03-113-05
作者:
贾艳增时东彦
(河北医科大学第二医院检验科,石家庄 050017)
Author(s):
JIA Yan-zeng SHI Dong-yan
(1.Department of Clinical Laboratory, the Second Affiliated Hospital ofHebei Medical University, Shijiazhuang 050017,China)
关键词:
碳青霉烯耐药高毒力肺炎克雷伯菌(CR-HvKP)替加环素多黏菌素体外联合药敏试验
分类号:
R378.996;R446.5
DOI:
10.3969/j.issn.1671-7414.2021.03.026
文献标志码:
A
摘要:
目的 研究替加环素与临床常用抗生素对碳青霉烯耐药高毒力肺炎克雷伯菌(hypervirulent and carbapenemresistant Klebsiella pneumonia, CR-HvKP)的体外联合抗菌活性。方法 收集 2017~2019 年河北医科大学第二医院临床分离非重复性 CR-HvKP 共 20 株。应用微量肉汤稀释法测定替加环素与 5 种抗生素的最低抑菌浓度(MIC),采用棋盘稀释法检测替加环素与 5 种抗生素(多黏菌素、头孢哌酮钠 / 舒巴坦钠、美罗培南、阿米卡星、磷霉素钠)的联合药敏试验。结果 20 株 CR-HvKP 主要来源于呼吸 ICU 13 例(65%),均为 ST11 型,碳青霉烯酶基因均为 KPC-2 型。血清型 12 株(60%)为 K2 型,为主要的血清型,1 株(5%)为 K1 型。拉丝试验及毒力基因 rmpA2 均为阳性。替加环素与多黏菌素出现协同作用,百分比为 60%。替加环素与美罗培南、磷霉素钠、头孢哌酮钠 / 舒巴坦钠均未出现协同作用。结论 替加环素与多黏菌素体外联合有协同作用,可供临床作为参考治疗 CR-HvKP 感染。

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:贾艳增(1990-),女,硕士研究生,主要从事细菌耐药机制的研究,E-mail: 2243433281@qq.com。
通讯作者:时东彦,E-mail:shidongyan73@163.com。
更新日期/Last Update: 1900-01-01