[1]刘亚东,齐 茗,王海晶,等.急性ST段抬高型心肌梗死患者Lp-PLA2基因多态性对PCI术后发生不良心脑血管事件的预测价值分析[J].现代检验医学杂志,2021,36(04):81-86.[doi:10.3969/j.issn.1671-7414.2021.04.017]
 LIU Ya-dong,QI Ming,WANG Hai-jing,et al.Analysis of the Predictive Value of Lp-PLA2 Gene Polymorphism in Patientswith Acute ST-Segment Elevation Myocardial Infarction for the Occurrenceof Adverse Cardiovascular and Cerebrovascular Events after PCI[J].Journal of Modern Laboratory Medicine,2021,36(04):81-86.[doi:10.3969/j.issn.1671-7414.2021.04.017]
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急性ST段抬高型心肌梗死患者Lp-PLA2基因多态性对PCI术后发生不良心脑血管事件的预测价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
81-86
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Analysis of the Predictive Value of Lp-PLA2 Gene Polymorphism in Patientswith Acute ST-Segment Elevation Myocardial Infarction for the Occurrenceof Adverse Cardiovascular and Cerebrovascular Events after PCI
文章编号:
1671-7414(2021)04-081-07
作者:
刘亚东齐 茗王海晶马利军屈晓威王丽萍冯莉莉
(延安大学附属医院心脑血管病区,陕西延安 716000)
Author(s):
LIU Ya-dong QI Ming WANG Hai-jing MA Li-jun QU Xiao-wei WANG Li-ping FENG Li-li
(Cardiovascular and Cerebrovascular Hospital, Affiliated Hospital of Yan’an University,Shaanxi Yan’an 716000,China)
关键词:
脂蛋白相关磷脂酶A2 基因多态性急性ST 段抬高型心肌梗死经皮冠状动脉介入治疗不良心脑血管事件
分类号:
R542.22;Q786
DOI:
10.3969/j.issn.1671-7414.2021.04.017
文献标志码:
A
摘要:
目的 探讨急性ST 段抬高型心肌梗死(acute ST-segment elevation myocardial infarction,STEMI)患者脂蛋白相关磷脂酶A2(lipoproteinassociated phospholipase A2,Lp-PLA2)基因多态性对经皮冠状动脉介入治疗(percutaneouscoronary intervention,PCI)术后心脑血管不良事件(major adverse cardiac and cerebral vascular events,MACCE)的预测价值。方法 选择2018 年1 月~2019 年8 月在延安大学附属医院确诊并行PCI 术的STEMI 患者183 例,PCI 术前采集静脉血,检测实验室指标及Lp-PLA2 基因R92H,V279F 和A379V 位点基因型,通过电话及门诊等方式随访1 年,记录MACCE,根据是否发生MACCE 将随访到的患者分为MACCE 组和非MACCE 组,通过t 检验、χ2 检验和Kaplan-Meier 生存曲线及COX 回归分析两组一般资料及Lp-PLA2 基因R92H,V279F 和A379V 基因型的差异。结果 随访1 年,共随访到168 例患者,其中58 例患者发生MACCE,占34.52%。MACCE 组和非MACCE 组Lp-PLA2 基因R92H 基因频率和等位基因频率差异有统计学意义(χ2=8.602 和11.409,均P < 0.005)。Lp-PLA2 基因R92H 位点RR 基因型与RH+HH 基因型患者MACCE,再次心肌梗死及心脏骤停比例差异有统计学意义(χ2=9.602,4.079 和7.348,均P < 0.05),Kaplan-Meier 生存曲线显示同样的结果(Log Rank 检验,χ2=8.373,4.309,8.937,均P < 0.05)。COX 回归显示Lp-PLA2 基因R92H 位点为RH+HH 基因型的STEMI 患者较RR 基因型PCI 术后发生MACCE 风险增加(OR=1.977,95%CI=1.396~3.221,P=0.007)。结论 STEMI 患者Lp-PLA2 基因R92H 位点基因多态性与PCI 术后发生MACCE 风险相关。

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备注/Memo

备注/Memo:
基金项目:陕西省教育厅专项科研计划项目(项目编号:20JK0981)。
作者简介:刘亚东(1988-),男,本科,主管检验师,研究方向:心血管疾病检验诊断。
通讯作者:冯莉莉,E-mail:769505260@qq.com。
更新日期/Last Update: 1900-01-01