[1]陶红莉,鲁晓波,吴　怡,等.急性脑损伤患者血清Tau，HMGB1水平检测在判断并发认知功能障碍风险的应用价值[J].现代检验医学杂志,2021,36(05):159-163.[doi:10.3969/j.issn.1671-7414.2021.05.035]
　TAO Hong-li,LU Xiao-bo,WU Yi,et al.Application Value of Serum Tau and HMGB1 Levels in Patients with AcuteBrain Injury in Judging the Risk of Cognitive Impairment[J].Journal of Modern Laboratory Medicine,2021,36(05):159-163.[doi:10.3969/j.issn.1671-7414.2021.05.035]
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急性脑损伤患者血清Tau，HMGB1水平检测在判断并发认知功能障碍风险的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年05期
页码:
159-163
栏目:
检验与临床
出版日期:
2021-10-14

文章信息/Info

Title:
Application Value of Serum Tau and HMGB1 Levels in Patients with AcuteBrain Injury in Judging the Risk of Cognitive Impairment
文章编号:
1671-7414（2021）05-159-05
作者:
陶红莉1; 鲁晓波2; 吴　怡1; 孙帼英1; 黄　刚1; 宋　雷1
（1. 咸阳市中心医院精神心理科，陕西咸阳712000；2. 宝鸡市康复医院心身科，陕西宝鸡721001）
Author(s):
TAO Hong-li1; LU Xiao-bo2; WU Yi1; SUN Guo-ying1; HUANG Gang1; SONG Lei1
（1.Department of Psychiatry, Xianyang Central Hospital, Shaanxi Xianyang 712000, China;2.Department ofPsychosomatic,Baoji Rehabilitation Hospital,Shaanxi Baoji 721001,China）
关键词:
血清Tau; 血清高迁移率组蛋白B1; 急性脑损伤
分类号:
R651.15；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.05.035
文献标志码:
A
摘要:
目的　研究血清Tau，高迁移率组蛋白B1（mobility group box-1 protein，HMGB1）联合检测判断急性脑损伤（acute brain injury，ABI）后并发认知功能障碍风险的临床价值。方法　收集2018年4月～2020年4月咸阳市中心医院168例ABI患者作为研究对象，随访记录认知障碍发生率。比较两组患者血清Tau和HMGB1水平，采用Logistic多因素分析法分析ABI后发生认知功能障碍的独立影响因素，采用受试者工作曲线（receiver operating characteristic，ROC）分析血清Tau和HMGB1联合预测认知功能障碍的价值。结果　168例患者中36例发生认知障碍，为观察组，另132例为对照组。观察组血清Tau和HMGB水平分别为347.84±75.51pg/ml和6.79±2.29μg/L，对照组分别为298.67±80.16pg/ml和4.96±1.08μg/L，两组间比较，差异均有统计学意义（t=3.30，6.84，均P<0.05）。不同血清Tau和血清HMGB1水平ABI患者文化程度、脑损伤程度、蒙特利尔认知评估量表（Montreal cognitive assessment，MoCA）评分及蛛网膜下腔出血、脑挫裂伤CT征象发生率比较，差异有统计学意义（χ2=7.37~34.30，6.74~50.60，均P<0.05）。Logistic多因素分析结果显示，文化程度、脑损伤程度、脑挫裂伤、血清Tau及血清HMGB1是ABI后认知功能障碍的独立影响因素（P<0.05）。基于Logistic多因素分析结果建立预测模型，Y1=1.03-0.75X1+0.46X2+0.56X3+0.62X4+0.81X5（X1=文化程度，X2=脑损伤程度，X3=脑挫裂伤，X4=血清Tau，X5=血清HMGB1）。Y2=1.03+0.62X4+0.81X5。Y1与Y2预测模型判断ABI患者并发认知障碍的AUC分别为0.85和0.84，两种预测模型判断认知障碍风险的AUC值比较，差异无统计学意义（P>0.05）。结论　血清Tau和血清HMGB1联合检测对判断ABI后认知功能障碍风险具有较高准确性。
Abstract:
Objective　To study the clinical value of combined detection of serum Tau and mobility group box-1 protein(HMGB1) in judging the risk of cognitive impairment after acute brain injury (ABI). Methods　168 patients with ABI inXianyang Central Hospital from April 2018 to April 2020 were selected as the research objects, and the incidence of cognitiveimpairment was recorded by followed up.The serum levels of Tau and HMGB1 were compared between the two groups,theLogistic multivariate analysis was used to analyze the independent influence factors of cognitive impairment after ABI.Thereceiver operating characteristic (ROC) was used to analyze the value of serum Tau and HMGB1 in predicting cognitiveimpairment. Results　Among 168 patients, 36 cases with cognitive impairment were as the observation group, and another 132cases were as the control group.The levels of Tau and HMGB1 in the observation group were 347.84±75.51pg/ml and6.79±2.29μg/L,the control group were 298.67±80.16pg/ml and 4.96±1.08μg/L, and the differences between the two groupswere statistically significant (t=3.30, 6.84, all P<0.05).There were significant differences in educational level,brain injurydegree,montreal cognitive assessment (MoCA) score,the incidence of subarachnoid hemorrhage and cerebral contusion andlaceration in patients with ABI of different levels of serum Tau, serum HMGB1 (χ2=7.37~34.30 and 6.74~50.60, all P<0.05).TheLogistic multivariate analysis showed that the education level, degree of brain injury, brain contusion, serum tau and serumHMGB1 were independent influence factors of cognitive impairment after ABI (all P<0.05).The prediction model was establishedbased on the results of logistic multivariate analysis,Y1=1.03-0.75X1+0.46X2+0.56X3+0.62X4+0.81X5 (X1 = educational level, X2 =degree of brain injury, X3 = brain contusion, X4 = serum tau, X5 = serum HMGB1),Y2=1.03+0.62X4+0.81X5.The AUC of Y1 and Y2prediction models for ABI patients with cognitive impairment were 0.85 and 0.84, respectively, and there was no significantdifference in AUC between the two models to judge the risk of cognitive impairment (P>0.05). Conclusion　The combineddetection of serum Tau and HMGB1 has high accuracy in judging the risk of cognitive impairment after ABI.

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备注/Memo

备注/Memo:
作者简介：陶红莉(1975-), 女，副主任医师，研究方向：双向情感障碍、抑郁症，E-mail:xiantaohongl@163.com.
通讯作者：吴怡(1986-)，女，主治医师，研究方向：生物精神病学，E-mail:1290711872@qq.com.
更新日期/Last Update: 1900-01-01