[1]欧鲤娴,孙清己,侯俊霞,等.脑梗死患者血清sdLDL，GSH-Px，Hcy及SDF-1水平与血管狭窄的相关性研究[J].现代检验医学杂志,2021,36(06):83-86.[doi:10.3969/j.issn.1671-7414.2021.06.017]
　OU Li-xian,Sun Qing-ji,HOU Jun-xia,et al.Study on the Correlation between Serum sdLDL, GSH-Px, Hcy and SDF-1 Levels and Vascular Stenosis in Patients with Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2021,36(06):83-86.[doi:10.3969/j.issn.1671-7414.2021.06.017]
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脑梗死患者血清sdLDL，GSH-Px，Hcy及SDF-1水平与血管狭窄的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
83-86
栏目:
论　著
出版日期:
2021-12-15

文章信息/Info

Title:
Study on the Correlation between Serum sdLDL, GSH-Px, Hcy and SDF-1 Levels and Vascular Stenosis in Patients with Cerebral Infarction
文章编号:
1671-7414（2021）06-083-05
作者:
欧鲤娴; 孙清己; 侯俊霞; 等
（1.宁德师范学院附属宁德市医院神经内科，福建宁德 352100；2.宁德市中医院脑病科；福建宁德 352100）
Author(s):
OU Li-xian;  Sun Qing-ji;  HOU Jun-xia;  et al
（1.Department of Neurology, Ningde Hospital Affiliated to Ningde Normal University，Fujian Ningde 352100，China；2.Department of Brain Disease, Ningde Traditional Chinese Medicine Hospital，Fujian Ningde 352100，China）
关键词:
小而密低密度脂蛋白; 谷胱甘肽过氧化物酶; 基质细胞衍生因子; 脑梗死
分类号:
R743.33；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.06.017
文献标志码:
A
摘要:
目的　研究脑梗死患者血清中小而密低密度脂蛋白(sdLDL)、谷胱甘肽过氧化物酶（GSH-Px）、同型半胱氨酸(Hcy)及基质细胞衍生因子1 (SDF-1)水平与血管狭窄的关系。方法　选取2018年1月～2020年5月期间宁德师范学院附属宁德市医院收治的120例脑梗死患者作为研究对象，按照有无血管狭窄分为狭窄组患者50例（轻度狭窄患者14例，中度狭窄患者16例，重度狭窄患者20例）和非狭窄组70例，另选取同期健康体检120例志愿者作为对照组，分析观察组与对照组、狭窄组与非狭窄组、不同狭窄程度的sdLDL，GSH-Px，Hcy及SDF-1水平之间的差异，研究血清sdLDL，GSH-Px，Hcy及SDF-1水平与脑梗死患者血管狭窄的相关性。结果　观察组患者的sdLDL，Hcy，SDF-1水平显著高于对照组（t=21.492，36.909，69.163，均P<0.05），GSH-Px水平显著低于对照组（t=11.190，P<0.05），差异均有统计学意义。狭窄组患者的sdLDL，SDF-1，Hcy水平显著高于非狭窄组（t=3.862，6.417，9.337，均P<0.05），GSH-Px水平显著低于非狭窄组（t=10.873，P<0.05），差异均有统计学意义。通过两两比较，三组患者的sdLDL（t =2.394~4.675，均P<0.05），SDF-1（t=4.111~9.112，均P<0.05），Hcy（t=2.346~5.938，均P<0.05）从高到低依次为重度组、中度组和轻度组，GSH-Px从高到低依次为轻度组、中度组和重度组（t=2.622~11.484，均P<0.05），差异均有统计学意义。Spearman相关性分析显示，患者的Hcy，sdLDL，SDF-1与血管狭窄程度呈正相关（r=0.334，0.526，0.741，均P＜0.05），患者的GSH-Px与血管的狭窄程度呈负相关（r=-0.441，P＜0.05）。结论　血清sdLDL，GSH-Px，Hcy和SDF-1水平与脑梗死患者血管狭窄呈显著相关性，可为临床的诊断提供重要依据。
Abstract:
Objective　To study the relationship between serum levels of sdLDL, GSH-Px and SDF-1 and vascular stenosis in patients with cerebral infarction. Methods　120 patients with cerebral infarction treated in Ningde Hospital Affiliated to Ningde Normal University from January 2018 to May 2020 were selected as the research objects. According to the presence or absence of vascular stenosis, they were divided into 50 patients in the stenosis group (14 patients with mild stenosis, 16 patients with moderate stenosis and 20 patients with severe stenosis) and 79 patients in the non stenosis group. In addition, 120 healthy volunteers in the same period were selected as the control group. The differences of sdLDL, GSH-Px, Hcy and SDF-1 levels between observation group and control group, stenosis group and non stenosis group, and different degrees of stenosis were analyzed to study the correlation between serum sdLDL, GSH-Px, Hcy and SDF-1 levels and vascular stenosis in patients with cerebral infarction. Results　The levels of sdLDL, Hcy and SDF-1 in observation group were significantly higher than those in control group (t=21.492, 36.909, 69.163, all P<0.05), while the level of GSH-Px in observation group was significantly lower than that in control group (t=11.190, P<0.05), with statistical significance. The levels of sdLDL, SDF-1 and Hcy in the stenosis group were significantly higher than those in the non-stenosis group (t=3.862, 6.417, 9.337, all P<0.05), and the level of GSH-Px was significantly lower than that in the non-stenosis group (t=10.873, P<0.05), with statistically significant differences. By pairings comparison, sdLDL (t=2.394~4.675, all P<0.05), SDF-1 (t=4.111~9.112, all P<0.05), Hcy (t=2.346~5.938, all P<0.05) from high to low were severe group, moderate group and mild group, GSH-Px from high to low were mild group, moderate group and severe group (t=2.622~11.484, all P<0.05), the differences were statistically significant. Spearman correlation analysis showed that sdLDL, SDF-1 and Hcy were positively correlated with the degree of vascular stenosis (r =0.334, 0.526, 0.741, all P < 0.05), while GSH-Px was negatively correlated with the degree of vascular stenosis (r =-0.441, P < 0.05).Conclusion　Serum sdLDL, GSH-Px and SDF-1 levels were significantly correlated with vascular stenosis in patients with cerebral infarction, which can be used as an important basis for clinical diagnosis in the future.

参考文献/References:

[1] 薛桥臻，王彤，李敬敬，等．血清sdLDL-C 水平与急性脑梗死发生及颈动脉粥样硬化斑块稳定性的关系[J]. 山东医药, 2019, 59(1):70-72.XUE Qiaozhen, WANG Tong, LI Jingjing, et al.Relationship between serum sdLDL-C level andoccurrence of acute cerebral infarction and stability ofcarotid atherosclerotic plaque [J]. Shandong MedicalJournal, 2019,59 (1): 70-72.
[2] 许位, 张园园, 高敬华, 等. 急性脑梗死患者血清sdLDL-C 与PTX-3 水平与颈动脉粥样硬化斑块性质的关系[J]. 中风与神经疾病杂志, 2019, 36(8): 704-707.XU Wei, ZHANG Yuanyuan, GAO Jinghua, et al. Therelationship between serum levels of sdLDL-C andPTX-3 and the occurrence of acute cerebral infarctionand the stability of carotid atherosclerotic plaque [J].Journal of Apoplexy and Nervous Diseases, 2019,36(8): 704-707.
[3] 康建华, 杨立顺, 袁海生. 脂蛋白相关磷脂酶A2 与急性脑梗死危险因素的相关性[J]．中国老年学杂志,2017, 37(2): 333-336.KANG Jianhua, YANG Lishun, YUAN Haisheng. Thecorrelation between lipoprotein-associated phospholipaseA2 and risk factors of acute cerebral infarction[J].Chinese Journal of Gerontology,2017,37(2):333-336.
[4] 朱同华，沈昊，沈国荣，等．老年脑梗死患者血清小而密低密度脂蛋白胆固醇水平与颈动脉狭窄的相关性[J]. 中国老年学杂志, 2012, 32(24):5405-5406．ZHU Tonghua, SHEN Hao, SHEN Guorong, et al.Correlation between serum small dense low densitylipoprotein cholesterol level and carotid artery stenosisin elderly patients with cerebral infarction [J]. ChineseJournal of Gerontology, 2012,32 (24): 5405-5406.
[5] 王胜奎, 周俊. 小而密低密度脂蛋白胆固醇在心脑血管系统相关疾病中的意义[J]. 检验医学, 2019,34(1):19-22.WANG Shengkui, ZHOU Jun. Role of small and denselow-density lipoprotein cholesterol in cardiovascularand cerebrovascular diseases [J]. Laboratory Medicine,2019,34 (1): 19-22.
[6] HU Guojie,FENG Yugong,LU Wenpeng, et al. Effect ofcombined VEGF(165)/ SDF-1 gene therapy on vascularremodeling and blood perfusion in cerebral ischemia[J].Journal of Neurosurgery, 2017, 127(3): 670-678.
[7] 杨云凤, 刘菊华, 刘利, 等. 超低频重复经颅磁刺激治疗老年人急性脑梗死吞咽障碍的疗效及对生存质量的影响[J]. 海南医学院学报,2020,26(3):214-218，225.YANG Yunfeng, LIU Juhua, LIU Li , et al. Effect ofultra-low frequency repetitive transcranial magneticstimulation on dysphagia in eld-erly patients with acutecerebral infarction and quality of life [J]. Journal ofHainan Medical University, 2020, 26(3): 54-59.
[8] POYURAN R, SRINIVAS B H, BADHE BA. Vasculitis causing massive infarction: a rarepresentation of primary cerebral phaeohyphomycosis[J].Tropical Doctor, 2018, 48(1): 40-43.
[9] XU Ji，ZHANG Yuan，LIANG Zhouyuan，et al.Normobaric hyperoxia retards the evolution of ischemicbrain tissue toward infarction in a rat model of transientfocal cerebral ischemia[J]. Neurological Research,2016, 38(1): 75-79.
[10] LIN Tingchun, LEE J D, LIN Yahui, et al. Timing ofsymptomatic infarct swelling following intravenousthrombolysis in acute middle cerebral artery infarction:A case–control study[J]. Clinical and Applied Thrombosis/Hemostasis, 2017, 23(7) : 814-820.
[11] SU Yingying, FAN Linlin, ZHANG Yunzhou, et al.Improved neurological outcome with mild hypothermiain surviving patients with massive cerebral hemisphericinfarction[J]. Stroke, 2016, 47(2): 457-463.
[12] 程小兵，罗娟娟，陈燕，等．血清小而密低密度脂蛋白胆固醇、同型半胱氨酸与颈动脉粥样硬化关系研究[J]．中国循证心血管医学杂志, 2021,13(2):173-177.CHENG Xiaobing, LUO Juanjuan, CHEN Yan, etal. Relationship among small and dense low densitylipoprotein cholesterol, homocysteine and carotidatherosclerosis [J]. Chinese Journal of Evidence-BasesCardiovascular Medicine, 2021, 13(2):173-177.
[13] KAUW F, BENNINK E, DE JONG H, e t a l .Intracranial cerebrospinal fluid volume as a predictor ofmalignant middle cerebral artery infarction[J]. Stroke,2019, 50(6): 1437-1443.
[14] 张珊珊，季一飞，张翼，等．音猬因子、小而密低密度脂蛋白胆固醇、25- 羟维生素D、转铁蛋白水平与老年急性脑梗死患者病情严重程度及预后的关系研究[J]. 实用医院临床杂志, 2020, 17(1): 33-36．ZHANG Shanshan, JI Yifei, ZHANG Yi, et al. Theassociation of the levels of SHH, sdLDL, 25 (OH) Dand TRF with severity and prognosis of elderly patientswith acute cerebral infarction [J]. Practical Journal ofClinical Medicine, 2020,17 (1): 33-36
[15] 阎其均, 朱付英, 胡明林. 冠心病患者血清sdLDL-C水平与冠状动脉病变程度的关系及其预后评价价值[J]. 检验医学与临床, 2021, 18(7): 1003-1004.YAN Qijun, ZHU Fuying, HU Minglin. Therelationship between serum sdLDL-C level and thedegree of coronary artery disease in patients withcoronary heart disease and its prognostic value[J].Laboratory Medicine and Clinic, 2021, 18(7): 1003-1004.
[16] 王宇鹏，王宏波，石婷，等．血清HCY 及LP(a) 的水平与冠心病的严重程度的相关性研究[J]. 湖南师范大学学报（医学版）,2021, 18(2):1-3.WANG Yupeng, WANG Hongbo, SHI Ting, et al.The research of correlation of serum homocysteineand lipoprotein (a) level with severity of coronaryatherosclerotic heart disease[J]. Journal of HunanNormal University(Medical Science), 2021, 18(2): 1-3.
[17] LI Weijuan, JIN Cheng, VAIDYA A, et al. Bloodpressure trajectories and the risk of intracerebralhemorrhage and cerebral infarction: a prospectivestudy[J]. Hypertension (Dallas, Tex. : 1979), 2017,70(3): 508-514.
[18] LI Zhiguo, ZHOU Xia . Correlation between thecondition of patients with acute cerebral infarction andserumβ2-microglobulin levels[J]. Journal of AcuteDisease, 2016, 5(4): 281-285.
[19] 陈霏，王碧．血清PDGF 及SDF-1 水平与急性脑梗死患者脑侧支循环建立的相关性研究[J]．现代检验医学杂志, 2020, 35(1):82-85.CHEN Fei, WANG Bi. Study on the correlationbetween levels of PDGF and SDF-1 in serum andthe establishment of cerebral collateral circulation inpatients with acute cerebral infarction [J]. Journal ofModern Laboratory Medicine, 2020,35 (1): 82-85.

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备注/Memo

备注/Memo:
作者简介：欧鲤娴（1990-），女，硕士，医师，主要从事神经内科相关方面的研究。通讯作者：侯俊霞（1980-），女，硕士，副主任医师，主要研究方向：脑血管病，E-mail：272580323@163.com。
更新日期/Last Update: 1900-01-01