[1]郭蔚虹,孙琼其,陈瑞娟.创伤性脑损伤患者血清IL-1β，MMP-9及TSPO水平与疾病程度及预后评估的价值研究[J].现代检验医学杂志,2021,36(06):162-165.[doi:10.3969/j.issn.1671-7414.2021.06.035]
　GUO Wei-hong,SUN Qiong-qi,CHEN Rui-juan.Value of Levels of Serum IL-1 β, MMP-9 and TSPO in Evaluating the Severity and Prognosis of Traumatic Brain Injury[J].Journal of Modern Laboratory Medicine,2021,36(06):162-165.[doi:10.3969/j.issn.1671-7414.2021.06.035]
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创伤性脑损伤患者血清IL-1β，MMP-9及TSPO水平与疾病程度及预后评估的价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
162-165
栏目:
检验与临床
出版日期:
2021-12-15

文章信息/Info

Title:
Value of Levels of Serum IL-1 β, MMP-9 and TSPO in Evaluating the Severity and Prognosis of Traumatic Brain Injury
文章编号:
1671-7414（2021）06-162-04
作者:
郭蔚虹; 孙琼其; 陈瑞娟
（海口市120急救中心急救科，海口 570311)
Author(s):
GUO Wei-hong;  SUN Qiong-qi;  CHEN Rui-juan
（Department of Emergency, 120 Emergency Center of Haikou City, Haikou 570311，China）
关键词:
创伤性脑损伤; 白细胞介素-1β; 基质金属蛋白酶-9; 转运蛋白; 预后评估
分类号:
R651.15；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.06.035
文献标志码:
A
摘要:
目的　探讨创伤性脑损伤（traumatic brain injury, TBI）患者血清白细胞介素-1β（IL-1β）、基质金属蛋白酶-9（MMP-9）及转运蛋白（translocator protein, TSPO）水平与疾病程度及预后评估的价值。方法　选取2018年1月~2020年10月海口市120急救中心收治的TBI患者117例，根据28天预后情况分为存活组（n=85）和死亡组（n=32）。采用格拉斯哥昏迷评分（GCS）分为轻度组（n=8，13~15分）、中度组（n=62，9~12分）和重度组（n=47，3~8分）。比较各组血清IL-1 β, MMP-9及TSPO水平。应用受试者工作特征（ROC）曲线分析血清IL-1β, MMP-9及TSPO水平预测TBI患者死亡的价值。结果　死亡组血清IL-1β（78.35±25.16ng/L），MMP-9（65.90±20.28 ng/L）及TSPO（8.26±3.15 ng/L ）水平均明显高于存活组（46.20±11.38ng/L，27.63±6.82ng/L和2.17±0.73ng/L）差异均有统计学意义（t=11.540，14.713和15.258，均P<0.001）。重度组血清IL-1β（72.74±23.90 ng/L），MMP-9（60.82±19.12 ng/L）及TSPO（6.70±2.84 ng/L）水平均明显高于轻中度组（51.36±13.15 ng/L，31.74±7.08ng/L和3.52±1.36ng/L），差异均有统计学意义（t=9.226，11.510和10.417，均P<0.001）。ROC曲线显示，IL-1 β, MMP-9及TSPO三项联合预测TBI患者死亡的曲线下面积（0.928，95%CI ：0.870~0.991）最大，其敏感度和特异度分别为95.0%和87.6%。相关分析显示，死亡组血清IL-1 β, MMP-9及TSPO水平之间均呈正相关（r=0.735~0.817，均P<0.001）。结论　血清IL-1β，MMP-9及TSPO水平升高与TBI患者的病情严重程度有关，三项联合检测对评估TBI患者的预后具有较好的价值。
Abstract:
Objective　To investigate the value of serum interleukin-1β (IL-1β), matrix metalloproteinase-9 (MMP-9) and transporter protein (TSPO) levels in patients with traumatic brain injury (TBI) and the degree of disease and prognosis. Methods　 117 patients with TBI admitted to 120 Emergency Center of Haikou City from January 2018 to October 2020 were selected and divided into survival group (n=85) and death group (n=32) according to the 28 days prognosis. Glasgow Coma Score (GCS) were divided into mild group (n=8, 13~15 Score), moderate group (n=62, 9~12 Score), severe group (n=47, 3~8 Score). The levels of serum IL-1β, MMP-9 and TSPO were compared in each group. Receiver operating characteristic (ROC) curves were used to analyze the value of serum IL-1β, MMP-9, and TSPO levels in predicting mortality in patients with TBI. Results　The levels of serum IL-1 β (78.35±25.16 ng/L), MMP-9 (65.90±20.28 ng/L) and TSPO (8.26±3.15 ng/L) in the death group were significantly higher than those in the survival group (46.20±11.38ng/L，27.63±6.82ng/L and 2.17±0.73ng/L), the differences were statistically significant(t=11.540, 14.713, 15.258, all P< 0.001) respectively. The levels of serum IL-1 β (72.74±23.90 ng/L), MMP-9 (60.82±19.12 ng/L) and TSPO (6.70±2.84 ng/L) in severe group were significantly higher than those in mild and moderate group (51.36±13.15 ng/L，31.74±7.08ng/L and 3.52±1.36ng/L), the differences were statistically significant(t=9.226, 11.510 and 10.417, all P< 0.001), respectively. The ROC curve showed that the area under the curve (0.928，95%CI ：0.870~0.991) of three items of IL-1β, MMP-9 and TSPO combined to predict the death of TBI patients was the largest, and its sensitivity and specificity were 95.0% and 87.6%, respectively. Correlation analysis showed that the levels of serum IL-1 β, MMP-9 and TSPO were positively correlated in the death group (r=0.735~0.817, all P<0.001). Conclusion　The elevated levels of serum IL-1β, MMP-9 and TSPO werer associated with the severity of the disease in patients with TBI, and the combination of these three tests has a good value in evaluating the prognosis of patients with TBI.

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备注/Memo

备注/Memo:
作者简介：郭蔚虹（1981-）,女，本科，主治医师，主要从事临床急诊急救医学研究，E-mail:reinbow2000@163.com。
更新日期/Last Update: 1900-01-01