[1]郑　茂a,陈宗耀a,鄂建飞a,等.高毒力肺炎克雷伯菌对碳青霉烯类耐药机制研究进展[J].现代检验医学杂志,2022,37(01):207-212.[doi:10.3969/j.issn.1671-7414.2022.01.043]
　ZHENG Maoa,CHEN Zong-yaoa,E Jian-feia,et al.Research Progress on the Mechanism of Hypervirulent Klebsiella Pneumoniae Resistance to Carbapenems[J].Journal of Modern Laboratory Medicine,2022,37(01):207-212.[doi:10.3969/j.issn.1671-7414.2022.01.043]
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高毒力肺炎克雷伯菌对碳青霉烯类耐药机制研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年01期
页码:
207-212
栏目:
综　述
出版日期:
2022-01-15

文章信息/Info

Title:
Research Progress on the Mechanism of Hypervirulent Klebsiella Pneumoniae Resistance to Carbapenems
文章编号:
1671-7414（2022）01-207-06
作者:
郑　茂a; 陈宗耀a; 鄂建飞a; 邹　玉b
（德阳市人民医院a. 检验科；b. 输血科，四川德阳 618000）
Author(s):
ZHENG Maoa; CHEN Zong-yaoa; E Jian-feia; ZOU Yub
（a. Department of Clinical Laboratory; b. Department of Blood Transfusion, People’s Hospital of Deyang City,Sichuan Deyang 618000, China）
关键词:
高毒力肺炎克雷伯菌; 碳青霉烯酶; 毒力; 耐药; 质粒
分类号:
R378.996；R446.5
DOI:
10.3969/j.issn.1671-7414.2022.01.043
文献标志码:
A
摘要:
高毒力肺炎克雷伯菌（ hypervirulent Klebsiella pneumoniae, hvKP）在临床分离株中检出率日益增加，携带多种毒力基因，致病力强，常导致严重的社区获得性感染。通常 hvKP耐药率低，临床治愈率高，但碳青霉烯类耐药株（carbpenem-resistant hypervirulent Klebsiella pneumoniae, CR-hvKP）的出现打破了这一平衡。 CR-hvKP集合高毒力、高耐药等特性，亦有“超级细菌”之称，极易造成致命性传播，迅速引发全球高度关注。该文将 hvKP对碳青霉烯类耐药机制作如下综述，旨在明确 CR-hvKP的形成途径，为遏制 CR-hvKP的出现及传播提供参考。
Abstract:
The detection rate of hypervirulent Klebsiella pneumoniae (hvKP) in clinical isolates is increasing. It carries multiplevirulence genes and is highly pathogenic, often leading to serious community-acquired infections. Generally, hvKP has a low drugresistance rate and a high clinical cure rate. However, the emergence of carbpenem-resistant hypervirulent Klebsiella pneumoniae(CR-hvKP) has broken this balance. CR-hvKP combines high virulence, high drug resistance and other characteristics, and is alsoknown as “superbug”. It is easy to cause fatal transmission and quickly arouses global attention. This article summarizes themechanism of hvKP resistance to carbapenems, aiming to clarify the formation theory of CR-hvKP, and provide a reference forcurbing the emergence and spread of CR-hvKP.

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备注/Memo

备注/Memo:
基金项目：德阳市科技计划重点研发项目（No.2020SZZ087）。
作者简介：郑茂（1989-），男，硕士，主管检验师，研究方向：临床微生物与感染，E-mail：zhengmao322@163.com。
通讯作者：邹玉，主管检验师，研究方向：临床微生物与感染，E-mail：676091264@qq.com。
更新日期/Last Update: 1900-01-01