[1]侯 越,赵 妍,王友明,等.脑卒中患者血清胱抑素C水平与卒中后认知障碍相关性的Meta分析[J].现代检验医学杂志,2022,37(02):142-147.[doi:10.3969/j.issn.1671-7414.2022.02.029]
 HOU Yue,ZHAO Yan,WANG You-ming,et al.Meta Analysis of the Correlation between Cystatin C Level in Stroke Patientis and Post Stroke Cognitive Impairment[J].Journal of Modern Laboratory Medicine,2022,37(02):142-147.[doi:10.3969/j.issn.1671-7414.2022.02.029]
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脑卒中患者血清胱抑素C水平与卒中后认知障碍相关性的Meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年02期
页码:
142-147
栏目:
论 著
出版日期:
2022-03-15

文章信息/Info

Title:
Meta Analysis of the Correlation between Cystatin C Level in Stroke Patientis and Post Stroke Cognitive Impairment
文章编号:
1671-7414(2022)02-142-06
作者:
侯 越1赵 妍1王友明2张如路2王敏佳2
(1. 河北工程大学临床医学院,河北邯郸 056000;2. 河北工程大学附属医院,河北邯郸 056000)
Author(s):
HOU Yue1 ZHAO Yan1 WANG You-ming2 ZHANG Ru-lu2WANG Min-jia2
(1.Hebei University of Engineering Clinical Medical College,Hebei Handan 056000,China;2. Affiliated Hospital of Hebei Engineering University, Hebei Handan 056000,China)
关键词:
卒中后认知障碍胱抑素CMeta分析
分类号:
R743.33;R446.11
DOI:
10.3969/j.issn.1671-7414.2022.02.029
文献标志码:
A
摘要:
目的 应用Meta 系统评价脑卒中患者血清胱抑素C(Cystatin C,Cys C)水平与卒中后认知障碍(post-stroke cognitive impairment,PSCI)的相关性。方法 通过检索PubMed,EMBASE,Web of Science,The Cochrane Library,WANFANG,谷歌学术、中国知网(CNKI)和维普中文期刊数据库(VIP),收集关于PSCI 和Cys C 相关性的文献。检索时间自数据库建库至2020 年12 月。对符合纳入标准的文献提取相关信息,采用RevMan 5. 3 及Stata14. 0 统计软件进行 Meta 分析。结果 共纳入10 项研究,病例组728 例,对照组898 例。Meta 分析结果显示:PSCI 组血清CysC 水平明显高于对照组(MD=0.37,95%CI:0.25~0.49,P < 0.000 01),病例组按照PSCI 病程时间进行亚组分析,结果显示病程< 14 天与≥ 14 天PSCI 亚组患者血清CysC 水平均高于对照组(MD=0.39,95%CI:0.11~0.68,P < 0.000 01;MD=0.41,95%CI :0.17~0.66,P < 0.000 01),差异均有统计学意义。结论 PSCI 患者的血清Cys C 水平高于卒中后认知正常患者,为PSCI 早期识别与筛查提供了部分客观的医学证据。
Abstract:
Objective To evaluate the correlation between cognitive impairment after stroke and the levels of cystatin C in stroke patientis by the system of Meta. Methods The databases including PubMed,Embase,Web of Science,the Cochrane Library,WanFang,Google Scholar,CNKI and VIP were searched to collect the literature about post stroke cognitive impairment and cystain C.The retrieval time was from the establishment of the database to December 2020. Extract the relevant information on literature met the inclusion criteria, using RevMan 5. 3 and Stata14. 0 statistical software Meta-analysis. Results  Ten studies were included, with 728 cases in the case group and 898 cases in the control group.Meta analysis results showed that the level of serum Cys C in the PSCI group was significantly higher than that in the control group (MD=0.37, 95%CI: 0.25 ~0.49, P < 0.000 01). Subgroup analysis was conducted according to the course of PSCI.The results showed that the serum Cys C level of the PSCI group was higher than that of the control group in the <14 days group and the ≥ 14 days group (MD=0.39, 95%CI: 0.11 ~ 0.68, P < 0.000 01; MD=0.41, 95%CI: 0.17 ~ 0.66, P < 0.000 01), the differences were statistically significant (all P < 0.05). Conclusion The results of this study indicated that the serum Cys C level of PSCI patients was higher than that of patients with normal post-stroke cognition, which provides some objective evidence-based medical evidence for the early identification and screening of PSCI.

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备注/Memo

备注/Memo:
基金项目:2019 年度河北省邯郸市科技局项目 ( 编号:19422083011-14)。
作者简介:侯越(1995-),女,在读硕士,医师,研究方向:卒中后认知障碍,E-mail:18839376226@163.com。
通讯作者:王友明,男,主任医师,硕士生导师,E-mail:wymhsm@126.com。
更新日期/Last Update: 1900-01-01