[1]徐　燕,李　晶.孕早期妇女血清人吻素、网膜素-1和Lipasin水平检测对早期预测妊娠期糖尿病发生风险的价值[J].现代检验医学杂志,2022,37(03):119-123.[doi:10.3969/j.issn.1671-7414.2022.03.025]
　XU Yan,LI Jing.Value of Serum Human Kisspeptin, Omentin-1 and Lipasin Levels in Early Pregnant Women for Early Prediction of the Risk of Gestational Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2022,37(03):119-123.[doi:10.3969/j.issn.1671-7414.2022.03.025]
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孕早期妇女血清人吻素、网膜素-1和Lipasin水平检测对早期预测妊娠期糖尿病发生风险的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
119-123
栏目:
论　著
出版日期:
2022-05-15

文章信息/Info

Title:
Value of Serum Human Kisspeptin, Omentin-1 and Lipasin Levels in Early Pregnant Women for Early Prediction of the Risk of Gestational Diabetes Mellitus
文章编号:
1671-7414（2022）03-119-06
作者:
徐　燕; 李　晶
（廊坊市第四人民医院/ 承德医学院附属医院产科，河北廊坊 065700）
Author(s):
XU Yan;  LI Jing
（Department of Obstetrics, the Fourth People’s Hospital of Langfang /Affiliated Hospital of Chengde Medical College, Hebei Langfang 065700, China）
关键词:
人吻素; 网膜素- １; Lipasin; 妊娠期糖尿病
分类号:
R714.256；R392.11
DOI:
10.3969/j.issn.1671-7414.2022.03.025
文献标志码:
A
摘要:
目的　探讨孕早期妇女血清人吻素（ human kisspeptin）、网膜素 -1（omentin-1）和 Lipasin水平检测对早期预测妊娠糖尿病 (gestational diabetes mellitus，GDM)发生风险的价值。方法　选取 2018年 3月～ 2021年 3月廊坊市第四人民医院接受定期产前检查的孕妇 256例，根据孕中期口服葡萄糖耐量实验（ OGTT）检查结果分为 GDM 组（n=136）和非 GDM 组（n=120）。比较两组一般临床资料、孕早期人吻素、网膜素 -１和 Lipasin血清水平。结果　①与非 GDM 组比较，GDM组孕早期人吻素（3.35 ± 0.95 nmol/L vs 2.19 ± 0.76 nmol/L）, Lipasin(3.29 ± 0.43 ng/ml vs 1.07 ± 0.06 ng/ml)血清水平增高 (t=4.964，16.798，均 P＜ 0.01)，孕早期网膜素 -１(216.73 ± 70.16 ng/ml vs 278.09 ± 93.45 ng/ml)血清水平降低 (t=3.326，P＜ 0.05) ，差异均有统计学意义。②孕早期人吻素血清水平与孕前 BMI，孕 24周前增重、 TG，FBG，1hPG，2hPG，FINS和 HOMA-IR呈正相关 ( r=0.286～ 0.564，均 P <0.05)，与 HOMA-β呈负相关 (r=-0.391，P <0.01)；网膜素 -１与孕前 BMI，孕 24周前增重、 FBG，1hPG，2hPG，FIN和 HOMA-IR呈负相关 (r=-0.619 ~ -0.206，均 P <0.05)，与 HOMA-β呈正相关 ( r=0.505，P <0.01)；Lipasin与孕 24周前增重、 TG，FBG， 1hPG，2hPG，FIN和 HOMA-IR呈正相关 ( r=0.363～ 0.611，均 P <0.01)，与 HOMA-β呈负相关 ( r=-0.496，P <0.01)。③孕 24周前增重、HOMA-IR，人吻素、网膜素 -１、Lipasin为 GDM发生的独立影响因素。④孕早期人吻素、网膜素 -１和 Lipasin血清水平预测 GDM发生风险的 AUC分别为 0.795，0.683和 0.619。三者联合检测的 AUC为 0.827，高于以上单一指标检测（ Z=-2.168，-2.509，-2.651，均 P＜ 0.05）。结论　GDM患者孕早期人吻素和 Lipasin血清水平升高，网膜素 -１血清水平降低，人吻素、网膜素 -１和 Lipasin均与糖脂代谢异常、 GDM发病有关，三者联合检测可用于 GDM早期诊断。
Abstract:
Objective　To investigate the value of the serum levels of human kisspeptin, omentin-1 and Lipasin in early pregnant women for early prediction of the risk of gestational diabetes mellitus(GDM). Methods　A total of 256 pregnant women who received regular prenatal examination in the Fourth People’s Hospital of Langfang from March 2018 to March 2021 were selected and divided into GDM group (n=136) and non-GDM group (n=120) according to the results of oral glucose tolerance test (OGTT) in mid-pregnancy.General clinical data, serum levels of human kisspeptin, Omentin-1, Lipasin and adverse pregnancy outcomes in the first trimester were compared between the two groups. Results　① Compared with the non-GDM group,the serum levels of human kisspeptin in early pregnancy (3.35 ± 0.95 nmol/L vs 2.19 ± 0.76 nmol/L) and Lipasin (3.29 ± 0.43 ng/ml vs 1.07 ± 0.06 ng/ml) in GDM group were higher (t=4.964，16.798，all P< 0.01), and the serum level of Omentin-1 (216.73 ± 70.16 ng/ml vs 278.09 ± 93.45 ng/ml) in early pregnancy was lower (t=3.326，P< 0.05)，the differences were statistically significant，respectively. ② The serum level of human kisspeptin in early pregnancy were positively correlated with BMI before pregnancy, weight gain before 24 weeks of pregnancy, TG, FBG, 1hPG, 2hPG, FINS and HOMA-IR (r=0.286 ～ 0.564, all P <0.05), but negatively correlated with HOMA-β (r=-0.391，P<0.05). The serum level of Omentin-1 in early pregnancy was negatively correlated with BMI before pregnancy, weight gain before 24 weeks of pregnancy, FBG, 1hPG, 2hPG, FINS and HOMA-IR (r = -0.619 ~ -0.206，all P <0.05)), and positively correlated with HOMA-β (r=0.505，P <0.01). The serum level of Lipasin in early pregnancy was positively correlated with weight gain before 24 weeks of pregnancy, TG, FBG, 1hPG, 2hPG, FINS and HOMA-IR(r=0.363 ～ 0.611，all P <0.01), and negatively correlated with HOMA-β (r=-0.496， P <0.01). ③ Weight gain before 24 weeks of pregnancy, HOMA-IR, human kisspeptin, Omentin-1 and Lipasin were the independent influencing factors for the occurrence of GDM. ④ The AUC of human kisspeptin, omentin-1 and Lipasin in predicting the risk of GDM were 0.795, 0.683 and 0.619, respectively. The AUC of the three indexes combined was 0.827, which higher than the above single indexes. Conclusion　In the early pregnancy of GDM patients, the serum levels of human kisspeptin and Lipasin increased, while the levels of Omentin-1 decreased. kisspeptin, Omentin-1 and Lipasin were associated with abnormal glucose and lipid metabolism, the incidence of GDM，the combined detection of GDM can be used for early diagnosis of GDM.

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备注/Memo

备注/Memo:
作者简介：徐燕（1980-），女，本科，主管护师，研究方向：妊娠期糖尿病风险预测，E-mail: well98765@163.com。
更新日期/Last Update: 1900-01-01