[1]泽汪格玛,杨建蓉,欧仕颖,等.慢性HBV感染患者血清CP，HNF1α与肝组织病理分级及分期的相关性研究[J].现代检验医学杂志,2022,37(03):177-181.[doi:10.3969/j.issn.1671-7414.2022.03.037]
　ZE Wanggema,YANG Jian-rong,OU Shi-ying,et al.Correlation between Serum CP, HNF 1α and Pathological Grading, Staging of Liver Tissues in Patients with Chronic HBV Infection[J].Journal of Modern Laboratory Medicine,2022,37(03):177-181.[doi:10.3969/j.issn.1671-7414.2022.03.037]
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慢性HBV感染患者血清CP，HNF1α与肝组织病理分级及分期的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
177-181
栏目:
检验与临床
出版日期:
2022-05-15

文章信息/Info

Title:
Correlation between Serum CP, HNF 1α and Pathological Grading, Staging of Liver Tissues in Patients with Chronic HBV Infection
文章编号:
1671-7414（2022）03-177-05
作者:
泽汪格玛; 杨建蓉; 欧仕颖; 余长芳
（甘孜藏族自治州人民医院 ，四川甘孜 626000）
Author(s):
ZE Wanggema;  YANG Jian-rong;  OU Shi-ying;  YU Chang-fang
(Ganzi Tibetan Autonomous Prefecture People’s Hospital, Sichuan Ganzi 626000, China)
关键词:
乙型肝炎病毒; 铜蓝蛋白; 肝细胞核因子1α; 肝组织炎症; 纤维化
分类号:
R512.62；R446
DOI:
10.3969/j.issn.1671-7414.2022.03.037
文献标志码:
A
摘要:
目的　分析慢性乙型肝炎病毒（ hepatitis B virus，HBV）感染者血清铜蓝蛋白（ ceruloplasmin，CP）、肝细胞核因子 1α（hepatocyte nuclear factor 1α，HNF 1α）与肝组织病理分级及分期的相关性。方法　选取 2018年 2月～ 2020年 12月于甘孜藏族自治州人民医院就诊并接受肝脏活组织检查的慢性 HBV感染者 158例，并选取同期医院内体检正常者 50例为对照组，检测血清 CP，HNF 1α，丙氨酸氨基转移酶（ alanine transferase，ALT）和天门冬氨酸氨基转移酶（aspartate amino transferase ，AST），并对慢性 HBV感染患者进行肝穿刺病理检查，评估组织炎症分级（ G0～ G3）和纤维化分期（ F0～ F4），分析患者血清 CP，HNF 1α水平与肝组织病理分级及分期的相关性。结果　感染组 CP（205.63±18.74 mg/L）和 HNF 1α（3.25±0.91 ng/ml）水平低于对照组（ 283.59±22.35 mg/L，6.38±0.83 ng/ml）， ALT（149.67±23.91 U/L）和 AST（109.84±19.23 U/L.）水平高于对照组（ 25.13±5.62 U/L，19.93±4.37 U/L），差异具有统计学意义（ t=21.634～ 36.457，均 P＜ 0.05）。＜ G2级患者 CP（211.37±20.54 mg/L）和 HNF 1α（3.42±1.05 ng/ml）水平高于 ≥ G2级者（ 186.86±15.32 mg/L，2.69±0.83 ng/ml）； ALT（134.56±17.68 U/L）和 AST（92.53±17.93 U/L）水平低于≥ G2级者（ 199.08±22.34 U/L，166.45±20.58 U/L），差异具有统计学意义（ t=3.872～ 21.183，均 P＜ 0.05）。＜ F2期患者 CP（215.69±21.37 mg/L）和 HNF 1α（3.58±1.12 ng/ml）水平高于 ≥ F2期者（ 171.54±16.64 mg/L，2.13±0.55 ng/ml）；ALT（130.25±16.52 U/L）和 AST（84.53±18.23 U/L）水平低于≥ F2期者（215.48±21.69 U/L，195.61±21.37 U/L），差异均具有统计学意义（ t=7.431～ 30.857，均 P＜ 0.05）。血清 CP和 HNF 1α升高分别是肝组织炎症（ OR=0.776，0.832）或纤维化显著（ OR=0.753，0.848）的独立保护因素（均 P＜ 0.05）；CP，HNF 1α分别与 ALT和 AST呈负相关性（r=-0.452，-0.429；-0.521，-0.483，均 P＜ 0.05）。结论　血清 CP和 HNF 1α水平与慢性 HBV感染患者病情严重程度密切相关，可反映肝组织炎症及纤维化进程。
Abstract:
Objective　To analyze the correlation between serum ceruloplasmin (CP), hepatocyte nuclear factor 1α (HNF 1α) and pathological grading, staging of liver tissues in patients with chronic hepatitis B virus (HBV) infection. Methods　A total of 158 patients with chronic HBV infection undergoing liver biopsy in Ganzi Tibetan Autonomous Prefecture People’s Hospital were enrolled from February 2018 to December 2020, while other 50 normal controls during the same period were enrolled as control group. The levels of serum CP, HNF 1α, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected. The pathological examination of liver puncture was applied in patients with chronic infection. The grading of tissue inflammation (G0 ～ G3) and fibrosis staging (F0 ～ F4) were assessed. The correlation between serum CP and HNF 1α levels and pathological grading, staging of liver tissues were analyzed. Results　The levels of CP (205.63±18.74 mg/L) and HNF 1α(3.25±0.91 ng/ml) in infection group were lower than those in control group（283.59±22.35 mg/L, 6.38±0.83 ng/ml）, while levels of ALT (149.67±23.91 U/L) and AST (109.84±19.23 U/L) were higher than those in control group（25.13±5.62 U/L，19.93±4.37 U/L）, the differences were statistically significant (t=21.634 ~ 36.457, all P ＜ 0.05). The levels of CP (211.37±20.54 mg/L) and HNF 1α (3.42±1.05 ng/ml) in ＜ G2 patients were higher than those in ≥ G2 patients （186.86±15.32 mg/L，2.69±0.83 ng/ml）, while levels of ALT (134.56±17.68 U/L) and AST (92.53±17.93 U/L) were lower than those in ≥ G2 patients（199.08±22.34 U/L, 166.45±20.58 U/L）, the differences were statistically significant (t=3.872 ～ 21.183, all P ＜ 0.05). The levels of CP (215.69±21.37 mg/L) and HNF 1α (3.58±1.12 ng/ml) in ＜ F2 patients were higher than those in ≥ F2 patients（171.54±16.64 mg/L，2.13±0.55 ng/ml）, while levels of ALT (130.25±16.52 U/L) and AST (84.53±18.23 U/L) were lower than those in ≥ F2 patients（215.48±21.69 U/L，195.61±21.37 U/L）, the differences were statistically significant (t=7.431 ~ 30.857, all P ＜ 0.05). The increased serum CP and HNF 1α were independent protective factors of significant inflammation (OR=0.776 ，0.832) or fibrosis (OR=0.753, 0.848) in liver tissues (P ＜ 0.05). CP and HNF 1αwere negatively correlated with ALT and AST (r=-0.452, -0.429; -0.521，-0.483, all P ＜ 0.05), respectively. Conclusion　The levels of serum CP and HNF 1αwere closely related to the conditions of patients with chronic HBV infection, which can reflect the process of inflammation and fibrosis in liver tissues.

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备注/Memo

备注/Memo:
作者简介：泽汪格玛（1984-），女，本科，主管检验师，研究方向：分子诊断，E-mail：zwgm21470@163.com。
更新日期/Last Update: 1900-01-01