[1]那将超,狄长安.甲状腺乳头状癌患者术后血清MMIF 和IL-6 表达水平与甲状旁腺功能减退持续时间的相关性研究[J].现代检验医学杂志,2023,38(01):191-194.[doi:10.3969/j.issn.1671-7414.2023.01.036]
　NA Jiang-chao,DI Chang-an.Correlation between Postoperative Serum MMIF and IL-6 Expression Levels and Duration of Hypoparathyroidism in Patients with Papillary Thyroid Cancer[J].Journal of Modern Laboratory Medicine,2023,38(01):191-194.[doi:10.3969/j.issn.1671-7414.2023.01.036]
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甲状腺乳头状癌患者术后血清MMIF 和IL-6 表达水平与甲状旁腺功能减退持续时间的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年01期
页码:
191-194
栏目:
检验与临床
出版日期:
2023-01-15

文章信息/Info

Title:
Correlation between Postoperative Serum MMIF and IL-6 Expression Levels and Duration of Hypoparathyroidism in Patients with Papillary Thyroid Cancer
文章编号:
1671-7414（2023）01-191-04
作者:
那将超; 狄长安
（北京市平谷区医院普外科，北京 101200）
Author(s):
NA Jiang-chao;  DI Chang-an
（Department of General Surgery, Beijing Pinggu Hospital, Beijing 101200, China）
关键词:
巨噬细胞移动抑制因子; 白细胞介素-6; 甲状腺乳头状癌; 甲状旁腺功能减退
分类号:
R736.1；R730.43
DOI:
10.3969/j.issn.1671-7414.2023.01.036
文献标志码:
A
摘要:
目的 探究甲状腺乳头状癌患者术后血清巨噬细胞移动抑制因子（macrophage movement inhibitory factor ，MMIF）和白细胞介素（interleukin ，IL）-6 表达水平与甲状旁腺功能减退持续时间的关系。方法 选取北京市平谷区医院2020 年5 月～ 2022 年2 月133 例甲状腺乳头状癌术后甲状旁腺功能减退患者，根据甲状旁腺功能减退持续时间的中位数将其分为长时组（＞ 8 周，n=65）和短时组（≤ 8 周，n=68）。酶联免疫吸附法检测血清MMIF 和IL-6 水平，并分析二者与甲状旁腺功能减退持续时间的关系。结果 长时组和短时组的年龄、女性占比、体质量指数、肿瘤直径、双侧中央区淋巴结清扫占比、术后引流量、包膜侵犯占比、甲状旁腺意外切除占比、术前血钙和甲状旁腺激素、术后第1 天的肿瘤坏死因子-α 水平，差异均无统计学意义（t/χ2/Z=0.123 ～ 1.401，均P ＞ 0.05）。与短时组相比，长时组的手术时间[114（102，139）min vs 101（95，114）min]、术后第1 天的MMIF(2.38±0.26 ng/ml vs 2.09±0.19ng/ml） 和IL-6 水平[14.10（12.47，15.13）ng/L vs 12.42（11.61，13.38）ng/L] 均升高， 差异具有统计学意义（Z/t=3.419 ～ 7.185，均P ＜ 0.05）。Pearson 分析结果显示log10（甲状旁腺功能减退持续时间）与MMIF 呈正相关关系（r=0.397，P=0.000）。Spearman 分析结果显示甲状旁腺功能减退持续时间与手术时间和IL-6 均呈正相关关系（rs=0.363，P=0.000；rs=0.281，P=0.001）。线性回归分析结果显示手术时间（t=2.734，P=0.007）、MMIF（t=4.265，P=0.000）和IL-6（t=3.006，P=0.003）均与甲状旁腺功能减退持续时间独立相关。结论 MMIF 和IL-6 与甲状旁腺功能减退持续时间呈正相关关系，二者水平高提示患者甲状旁腺功能减退持续时间长。
Abstract:
Objective To investigate the relationship between postoperative serum macrophage movement inhibitory factor (MMIF) and interleukin-6 (IL-6) expression levels and the duration of postoperative hypoparathyroidism in patients with papillary thyroid cancer. Methods 133 patients with postoperative hypoparathyroidism in papillary thyroid cancer in Beijing Pinggu Hospital from May 2020 to February 2022 were selected as the study subjects. Patients were divided into the long duration group (＞ 8 weeks, n=65) and the short duration group (≤ 8 weeks, n=68) based on the median duration of hypoparathyroidism. Serum MMIF and IL-6 levels were measured by enzyme-linked immunosorbent assay（ELISA）, and their relationship with the duration of hypoparathyroidism was analyzed. Results The differences of age, proportion of females, body mass index, tumour diameter, percentage of lymph node dissection in the central region bilaterally, postoperative drainage, percentage of envelope violations, accidental parathyroidectomy, preoperative blood calcium and parathyroid hormone, and tumour necrosis factor-α on postoperative day 1th in the long duration group and the short duration group were not statistically significant (t/χ2/Z=0.123 ～ 1.401, all P ＞ 0.05). Compared with the short duration group, the levels of operative time [114 (102, 139) min vs 101 (95, 114) min], MMIF (2.38±0.26 ng/ml vs 2.09±0.19 ng/ml) and IL-6 [14.10 (12.47, 15.13) ng/L vs 12.42 (11.61, 13.38) ng/L] in the long duration group were elevated (Z/t=3.419 ～ 7.185, all P ＜ 0.05). Pearson analysis showed a positive correlation between log10 (duration of hypoparathyroidism) and MMIF (r=0.397, P=0.000). Spearman analysis showed a positive correlation between the duration of hypoparathyroidism and both the operation time and IL-6 (rs=0.363, 0.281, P=0.000, 0.001). Linear regression analysis showed that operation time (t=2.734, P=0.007), MMIF (t=4.265, P=0.000) and IL-6 (t=3.006, P=0.003) were all independently associated with the duration of hypoparathyroidism. Conclusion MMIF and IL-6 were positively correlated with the duration of hypoparathyroidism. The high levels of MMIF and IL-6 indicate that the duration of hypoparathyroidism would be long.

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备注/Memo

备注/Memo:
基金项目：北京市平谷区医院科研项目（pgyy2021-05）。
作者简介：那将超（1980-），男，硕士，副主任医师，主要从事甲状腺手术相关研究。
通讯作者：狄长安（1965-），男，本科，主任医师，Email：pinggudca65@163.com。
更新日期/Last Update: 2023-01-15