[1]周莉莉a,刘 栋a,耿 丹a,等.陕西铜川地区＜ 18 岁健康人群血清CK，CK-MB，LDH 参考区间的建立与验证[J].现代检验医学杂志,2023,38(02):176-180.[doi:10.3969/j.issn.1671-7414.2023.02.033 ]
　ZHOU Li-lia,LIU Donga,GENG Dana,et al.Establishment and Verification of Reference Interval of Serum CK, CK-MB and LDH in Healthy Population Under 18 Years Old in Tongchuan Area of Shaanxi[J].Journal of Modern Laboratory Medicine,2023,38(02):176-180.[doi:10.3969/j.issn.1671-7414.2023.02.033 ]
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陕西铜川地区＜ 18 岁健康人群血清CK，CK-MB，LDH 参考区间的建立与验证()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年02期
页码:
176-180
栏目:
检验与临床
出版日期:
2023-03-15

文章信息/Info

Title:
Establishment and Verification of Reference Interval of Serum CK, CK-MB and LDH in Healthy Population Under 18 Years Old in Tongchuan Area of Shaanxi
文章编号:
1671-7414（2023）02-176-05
作者:
周莉莉a; 刘 栋a; 耿 丹a; 宋宏庆a; 刘 涛a; 陈 斌a; 张碧莹a; 叶宝妮b; 王剑峰a
（铜川市人民医院 a.检验科；b.儿科，陕西铜川 727000）
Author(s):
ZHOU Li-lia;  LIU Donga;  GENG Dana;  SONG Hong-qinga;  LIU Taoa;  CHEN Bin1;  ZHANG Bi-yinga;  YE Bao-nib;  WANG Jian-fenga
(a. Department of Clinical Laboratory；b. Department of Pediatrics, Tongchuan People’s Hospital ,, ()Shaanxi Tongchuan 727000，China)
关键词:
肌酸激酶; 肌酸激酶同工酶; 乳酸脱氢酶; 儿童; 青少年; 参考区间
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2023.02.033
文献标志码:
A
摘要:
目的 建立和验证陕西铜川地区＜ 18岁健康人群血清肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）及乳酸脱氢酶（LDH）参考区间。方法 选取 2019年 1月～2021年 12月在铜川市人民医院进行健康体检的＜ 18岁健康儿童及青少年 1 606例作为研究对象，其中男性 804例，女性 802例。按年龄分为 5组，其中 1～12月龄组 325例，1～3岁组 328例，4～6岁组 322例，7～12岁组 326例，13～18岁组 305例。采用日立 7600全自动生化分析仪检测血清 CK，CK-MB和 LDH水平，通过计算相邻两组间 Z和 Z*，进一步比较不同性别和不同年龄组间是否可以合并。合并后各组采用百分位数法确定其参考区间。根据合并后各组特征，每组于 2022年 1～2月随机选取健康体检的 20例样本验证已建立的血清 CK，CK-MB和 LDH的参考区间。结果 ①陕西铜川地区＜ 18岁健康人群血清 CK，CK-MB和 LDH活性与年龄呈负相关（r = -0.407，-0.946，-0.968，均 P＜ 0.05）。②按性别分组：血清 CK在 13～18岁组男、女检测值 Z＞ Z*（7.81>3.38），不可合并，三个项目其他各年龄组男、女检测值均为 Z＜ Z*，可合并。按年龄分组：血清 CK-MB （Z和 Z*）在 1～3岁组与 4～6岁组为 9.10>4.94，7～12岁与 13～18岁组为 8.38>4.87；血清 LDH（Z和 Z*）在 1～3岁组与 4～6岁组为 7.84>4.94，4～6岁组与 7～12岁组为 9.13>4.93，7～12岁组与 13～18岁组为 10.64>4.87，均为 Z>Z*，不可合并。其他各组间检测值均为 Z
Abstract:
Objective To establish and verify the reference interval of serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) for healthy children and adolescents aged 1 month to 18 years in Tongchuan area. Methods 1 606 healthy children and adolescents aged 1 month to 18 years old who underwent physical examination in Tongchuan People’s Hospital from January 2019 to December 2021 were selected as the research objects, including 804 males and 802 females. They were divided into 5 groups according to age, including 325 cases in the 1～12-month-old group, 328 cases in the 1～3-year-old group, 322 cases in the 4～6-year-old group, and 326 cases in the 7～12-year-old group, 305 cases in 13～18 years old group. To detect serum CK, CK-MB and LDH levels by using Hitachi 7600 automatic biochemical analyzer, calculate Z and Z* between two adjacent groups, and compare whether there was combination between different genders and different age groups. After the combination, each group uses the percentile method to determine its reference interval.According to the characteristics of each group after the combination, each group selected 20 samples of physical examination to verify the established reference interval of CK, CK-MB and LDH from January 2022 to February 2021. Results ① CK, CK-MB and LDH activity were negatively correlated with age (r = -0.407，-0.946, -0.968, all P <0.05). ② According to gender grouping CK in 13~18 years old group male and female test value Z>Z*(7.81>3.38), could not be combined. Three items other age groups male, female test values were Z>Z*, which can be combined. According to age group Z and Z* in CK-MB group of 1～3 years old and group of 4～6 years old (9.10>4.94), the group aged 7～12 years old and 13～18 years old was (8.38>4.87)，LDH was (7.84>4.94) in the group aged 1～3 years old and the group aged 4～6 years old, the groups aged 4～6 years old and 7～12 years old were 9.13>4.93, and the groups aged 7～12 years old and 13～18 years old were 10.64>4.87. All were Z>Z* and cannot be merged. The detection values among other groups were Z

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相似文献/References:

[1]游青青a,杨海健a,杨宇b,等.抑郁症患者血清脂质及CK,LDH水平与疾病程度的相关性分析[J].现代检验医学杂志,2019,34(01):79.[doi:10.3969/j.issn.1671-7414.2019.01.020]
　YOU Qing-qinga,YANG Hai-jiana,YANG Yub,et al.Correlation Analysis of Serum Lipids，CK，LDH and Course of Disease in Patients with Depression[J].Journal of Modern Laboratory Medicine,2019,34(02):79.[doi:10.3969/j.issn.1671-7414.2019.01.020]

备注/Memo

备注/Memo:
收稿日期：2022-08-28修回日期：2022-11-07
基金项目：2020年西安市卫生健康委员会科研项目（NO2020yb74）。
作者简介：夏爱军（1968-），女，主任技师，硕士，研究方向：免疫血型血清学， E-mail:417962396@qq.com。

更新日期/Last Update: 2023-03-15