[1]秦辛玲,石青峰.高泌乳素患者不同时间段泌乳素水平研究[J].现代检验医学杂志,2015,30(01):85-87.[doi:10.3969/j.issn.1671-7414.2015.01.023]
　QIN Xin-ling,SHI Qing-feng.Study of Prolactin Level Changes of Patients with Hyperprolactinemia in Different Time Period[J].Journal of Modern Laboratory Medicine,2015,30(01):85-87.[doi:10.3969/j.issn.1671-7414.2015.01.023]
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高泌乳素患者不同时间段泌乳素水平研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
85-87
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Study of Prolactin Level Changes of Patients with Hyperprolactinemia in Different Time Period
文章编号:
1671-7414(2015)01-085-03
作者:
秦辛玲; 石青峰
桂林医学院附属医院检验科,广西桂林 541001
Author(s):
QIN Xin-ling; SHI Qing-feng
Departement ofClinical Medicine, the Affiliated Hospital of Guilin Medical College,Guangxi Guilin 541001,China
关键词:
泌乳素;  巨泌乳素;  采样时间;  高泌乳素血症
分类号:
R584; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.01.023
文献标志码:
A
摘要:
目的 探讨高泌乳素血症患者泌乳素水平在不同时间段的变化。方法 使用电化学发光法、罗氏E170全自动免疫分析仪测定124例高泌乳素(PRL>880 uIU/ml),女性患者在7:30AM,10:00AM及4:00PM不同时间段血浆泌乳素(PRL)水平,并根据经聚乙二醇(PEG)6000沉淀巨泌乳素后的PRL回收率分成巨泌乳素组(回收率≤40%)、单泌乳素组(回收率>60%)、可疑泌乳素组(40%<回收率≤60%),同时检测45例正常对照组的PRL水平。结果 高泌乳素组巨泌乳素阳性率(33.1%)与正常对照组中巨泌乳素阳性率(0.0%)比较,差异有统计学意义(χ2=17.886 7,P<0.05),巨泌乳素组及单体泌乳素组经PEG处理前在10:00AM时间段的泌乳素浓度(1160±714 uIU/ml,885±801 uIU/ml)与7:30AM时间段的泌乳素浓度(1 521±914 uIU/ml,1 497±845 uIU/ml)差异均有统计学意义(t=1.993,4.46,P<0.05),巨泌乳素组及单体泌乳素组经PEG处理后在10:00AM时间段的泌乳素浓度(316±231 uIU/ml,766±611 uIU/ml)与7:30AM时间段的泌乳素浓度(488±394 uIU/ml,1235±912 uIU/ml)差异均有统计学意义(t=2.411 4,3.625 2,P<0.05),单泌乳素组4:00PM时间段处理前的泌乳素浓度(1 033±911 uIU/ml)与7:30AM时间段处理前的泌乳素浓度(1 497±845 uIU/ml)差异也有统计学意义(t=3.168 6,P<0.05)。结论 不同时间段泌乳素水平有变化,确定正确的采血时间,有助于临床对高泌乳素血症的诊断。
Abstract:
Objective To investigate prolactin(PRL)levelsin patient with hyperprolactinemia in different period of time.Methods Used electrochemical luminescence method,Roche E170 automatic immune analyzer determination of detect 124 cases female patients of hyperprolactinemia(PRL>880 uIU/ml)at 7:30AM,10:00AM and 4:00PM respectivelye of plasmaPRL level,and in accordance with the polyethylene glycol(PEG)6000 precipitate PRL after A PRL recovery rate of into macroprolactin(MPRL)group(A PRL recovery rate of ≤40%),single PRL group(A PRL recovery rate of > 60%),suspiciousPRL group(40%<A PRL recovery rate of ≤60%),and simultaneous detect PRL levels in 45 cases of normal control group.Results MPRL positive rate(33.1%)of high PRL group and MPRL positive rate(0%)of normal control group comparison,showed significant differences(χ2=17.886 7,P<0.05).MPRL group and single PRL group untreated by PEG at 10:00AM the PRL levels(1 160±714 uIU/ml,885±801 uIU/ml)and at 7:30AM the PRL levels(1 521±914uIU/ml,1 497±845 uIU/ml)showed significantdifferences(t巨=1.993,t单=4.46,P<0.05).MPRL group and single PRL group treated by PEG at 10:00AMof the PRL levels(316±231 uIU/ml,766±611 uIU/ml)and at 7:30AM of the PRLlevels(488±394 uIU/ml,1 235±912 uIU/ml)showed significant differences(t巨=2.411 4,t单=3.625 2,P<0.05).Single PRL group untreated by PEG at 4:00PM PRL levels(1 033±911 uIU/ml)and at 7:30AM PRL levels(1 497±845uIU/ml)also showed significant differences(t=3.168 6,P<0.05).Conclusion PRL levels was changed in different time.Determiningthe sampling time correct,conduce to the diagnosis of hyperprolactinemia clinical.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:广西壮族自治区卫生厅自筹经费科研课题(Z2009060)。
作者简介:秦辛玲(1971-),女,研究生,副主任技师,主要从事临床免疫检验及研究工作,E-mail:gyqxl1@163.com。
通讯作者:石青峰,E-mail:sqf7217@163.com。
更新日期/Last Update: 2015-01-30