[1]黄道桂,任传路,虞红艳,等.血清PGⅠ,PGⅡ,TK1,TSGF,CEA与CA724 联合检测在胃癌诊断中的应用价值[J].现代检验医学杂志,2015,30(01):101-104.[doi:10.3969/j.issn.1671-7414.2015.01.028]
　HUANG Dao-gui,REN Chuan-lu,YU Hong-yan,et al.Application Value of Combined Detection of PGⅠ,PGⅡ,TK1, TSGF,CEA and CA724 in Diagnosis of Gastric Cancer[J].Journal of Modern Laboratory Medicine,2015,30(01):101-104.[doi:10.3969/j.issn.1671-7414.2015.01.028]
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血清PGⅠ,PGⅡ,TK1,TSGF,CEA与CA724 联合检测在胃癌诊断中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
101-104
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Application Value of Combined Detection of PGⅠ,PGⅡ,TK1, TSGF,CEA and CA724 in Diagnosis of Gastric Cancer
文章编号:
1671-7414(2015)01-101-04
作者:
黄道桂1; 任传路2; 虞红艳2; 刘 芳2; 丁庆莉2
1.泰州市妇幼保健院检验科,江苏泰州 225300;
2.解放军100医院检验病理科,江苏苏州 215007
Author(s):
HUANG Dao-gui1; REN Chuan-lu2; YU Hong-yan2; LIU Fang2; DING Qing-li2
1.Department of Clinical Laboratory,Maternal and Child Care Service Center in Taizhou,Jiangsu Taizhou 225300,China;
2.Department of Laboratory Medicine and Pathdogy, the 100th Hospital of People's Liberation Army,Jiangsu Suzhou 215007,China
关键词:
胃蛋白酶原(PGⅠ; PGⅡ);  胸苷激酶1;  恶性肿瘤生长因子;  癌胚抗原;  糖类抗原724;  联合检测;  胃癌
分类号:
R735.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2015.01.028
文献标志码:
A
摘要:
目的 通过检测PGⅠ,PGⅡ,TK1,TSGF,CEA与CA724在胃癌患者血清中的表达水平,并进行联合检测比较,探讨上述几项肿瘤标志物单独或联合检测在胃癌中的临床诊断价值。方法 收集94例胃癌患者和85例健康体检者血清,速率法检测恶性肿瘤生长因子(TSGF),化学发光法检测PGⅠ,PGⅡ,TK1,CEA和CA724表达水平。结果 胃癌组PGⅠ检测值及PGⅠ/PGⅡ比值均明显降低,差异具有统计学意义(P均<0.01); PGⅡ变化不明显(P>0.05); TK1,TSGF,CEA和CA724检测值升高,差异具有统计学意义(均P<0.05)。敏感度指标由高到低分别为PGⅠ,PGⅠ/PGⅡ,TSGF,TK1,CEA和CA724,其中PGⅠ和PGⅠ/PGⅡ诊断敏感度高于TK1,CEA和CA724单独检测,差异具有统计学意义(均P<0.05); 特异度指标由高到低分别为PGⅠ/PGⅡ,CEA,PGⅠ,CA724,TK1和TSGF(此研究中PGⅠ和CA724特异度相同),其中PGⅠ/PGⅡ,CEA单项诊断特异度高于TSGF,差异具有统计学意义(均P<0.05); 准确度指标由高到低分别为PGⅠ,PGⅠ/PGⅡ,CEA,TK1,CA724和TSGF,其中PGⅠ,PGⅠ/PGⅡ单项诊断准确度高于CA724和TSGF,差异有统计学意义(均P<0.05)。TSGF,TK1联合PGⅠ/PGⅡ,PGⅠ检测,可提高诊断敏感度(P<0.05); 加入CEA,CA724联合检测后敏感度更高,高达82.98%; 联合检测使诊断特异度有所降低,但仍高达84.71%; 联合检测可提高胃癌诊断准确度,最高达83.80%。此研究中PGⅠ+PGⅠ/PGⅡ+TSGF+TK1+CEA联合检测组合,在加或不加CA724情况下三项诊断效率指标均无变化。结论 PGⅠ/PGⅡ,PGⅠ在胃癌诊断中的临床应用价值最高,且高于目前广泛应用的CEA和CA724。组合PGⅠ+PGⅠ/PGⅡ+TSGF+TK1+CEA对胃癌诊断的敏感度最高。临床中若将PGⅠ,PGⅠ/PGⅡ,TSGF,TK1和CEA这几项指标联合检测可有效提高胃癌的诊断效率。
Abstract:
Objective To investigate the serum levels of PGⅠ,PGⅡ,TK1,TSGF and CEA,CA724 in gastric cancer and evaluate the application value of combined detection the above tumor markers in diagnosis of gastric cancer.Methods The serum levels of TSGF were measured in94 patients with gastric cancer and 85 healthy control by rate method.PGⅠ,PGⅡ,TK1 and CEA,CA724 were detected by electrochemiluminescence method.Results PGⅠand PGⅠ/PGⅡwere lower than healthy control in serum of patients with gastric cancer(both P<0.05).There was no difference inPGⅡ(P>0.05),and other tumor markers were all higher than healthy control(all P<0.05).The sensitivity of PGⅠ,PGⅠ/PGⅡ were better than TK1,CEA and CA724(all P<0.05),the specificity of PGⅠ/PGⅡ,CEA were better than TSGF(both P<0.05),the accuracy of PGⅠ,PGⅠ/PGⅡ were better than CA724 and TSGF alone(all P<0.05).When combined TSGF,TK1 and PGⅠ/PGⅡ,PGⅠ,thesensitivity was better than combined PGⅠ/PGⅡand PGⅠ alone(P<0.05).Then when added CEA,CA724,this sensitivity improved up to 82.98%.Although thecombined detection would show a lower specificity,it still keep high to 84.71%.Combined detection improved the accuracy in diagnosis of gastric cancer,up to83.80%.In this research,There was no difference in sensitivity,specificityand accuracy between the group of PGⅠ+PGⅠ/PGⅡ+TSGF+TK1+CEA and the group of PGⅠ+PGⅠ/PGⅡ+TSGF+TK1+CEA+CA724.Conclusion Compared with CEA and CA724 popular used in clinic,PGⅠ/PGⅡand PGⅠshowed a better application value.The group of PGⅠ+PGⅠ/PGⅡ+TSGF+TK1+CEA showed the best sensitivity.Combined detection of serum levels of PGⅠ,PGⅠ/PGⅡ,TSGF,TK1,CEA can significantly raise the sensitivity and accuracy in diagnosis of gastric cancer.

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备注/Memo

备注/Memo:

作者简介:黄道桂(1980-),女,本科,主管检验技师,主要从事肿瘤免疫诊断方面的研究,E-mail:466380736@qq.com。
更新日期/Last Update: 2015-01-30