[1]谈 昀,丁晓勇,白 晓.产β-内酰胺酶大肠埃希菌的临床分布及耐药性分析[J].现代检验医学杂志,2015,30(02):74-76.[doi:10.3969/j.issn.1671-7414.2015.02.023]
　TAN Yun,DING Xiao-yong,BAI Xiao.Clinical Distribution and Drug-resistance Analysis of 1 587 Escherichia coli[J].Journal of Modern Laboratory Medicine,2015,30(02):74-76.[doi:10.3969/j.issn.1671-7414.2015.02.023]
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产β-内酰胺酶大肠埃希菌的临床分布及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
74-76
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Clinical Distribution and Drug-resistance Analysis of 1 587 Escherichia coli
作者:
谈 昀; 丁晓勇; 白 晓
武警陕西省总队医院,西安710054
Author(s):
TAN Yun; DING Xiao-yong; BAI Xiao
Department of Clinical Laboratory, Shaanxi Corps Hospital of Chinese People's Armed Police Forces,Xi'an 710054,China
关键词:
大肠埃希菌;  超广谱β-内酰胺酶;  耐药性;  多耐药
分类号:
R378.21; R446.5
DOI:
10.3969/j.issn.1671-7414.2015.02.023
文献标志码:
A
摘要:
目的 分析医院2012年1月～2014年12月分离的产β-内酰胺酶(ESBLs)大肠埃希菌临床分布与耐药性,为临床合理使用抗菌药物提供依据。方法 住院患者中分离1 587株大肠埃希菌进行回顾性分析,采用珠海迪尔公司微生物鉴定仪进行鉴定和药敏试验,用表型确证实验检测ESBLs。结果 1 587株大肠埃希菌中检出产ESBLs菌株为901株(56.8%),主要分布科室为泌尿外科、内分泌科、呼吸科; 标本来源主要分布为尿液609株(47.3%),痰液411株(31.9%),血液83株(6.5%); 产ESBLs菌株大肠埃希菌对亚胺培南耐药率为0; 对青霉素类、头孢菌素类的耐药性>90.0%,对左旋氧氟沙星、环丙沙星耐药性>70.0%; 对阿莫西林/克拉维酸、替卡西林/克拉维酸、哌拉西林/他唑巴坦、阿米卡星耐药率较低<7.7%。结论 近3年医院临床分离的大肠埃希菌耐药性呈逐年增高趋势,产超广谱β-内酰胺酶(ESBLs)大肠埃希菌检出率逐年升高,表现为多耐药,因此,加强耐药性检测和监测,对指导合理使用抗菌药物非常重要。
Abstract:
Objective To analyze the β-lactamases-producing Escherichia coli which were isolated from hospital specimens from Jun 2012 to Dec 2014,and provide a more accurate evidence to guide drug-selecting for antibacterial use.Methods Analyzed 1 587 E.coli from patient sample selected between Jun 2012～Dec 2014 using the microbial analysis system manufactured by ZHUHAI DL BIOTECH CO.LTD,A phenotypic test was alsoconducted to test ESBLs.Results 1 587 stains of E.coli were isolated,which counted for 23.9% of the specimens; 901 stains(56.8%)out of total 1 587 stains appeared to be ESBLs-producing E.coli,and others were non- ESBLs-producing E.coli.The 1 587 Escherichia coli mainly came from Department of Urology(408,weight 25.7%),Department of Endocrinology(271,weight 17.1%),Department of Respiration(249,weight 15.7%).Rinespecimen contributed 609 stains(47.3%),411 E.coli stains(31.9%)werediscovered in sputum samples,and 83 stains(6.5%)showed in blood samples.The resistance to imipenem were discovered in the analysis.The rates of resistance to penicillins,cephalosporins were over 90.0%,the rates of resistance to Levofloxacin,ciprofloxacin were above 70.0%,and resistance rates to amoxicillin-clavulanic acid,Ticarcillin-clavulanic acid,piperacillin/tazobactam,amikacin were lower than 7.7%.Conclusion The drug-resistanceof the E.coli were increasing over the past three years.There was a significant portion of MDR and PDR present in the trend.Thus,the reinforcement of the drug-resistance survey and testing have a far-reaching meaning to promote rational drug selecting.

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备注/Memo

备注/Memo:
作者简介:谈 昀(1972-),女,副主任技师,主要从事微生物及临床生化研究,E-mail:chhhty@sina.com。
更新日期/Last Update: 2015-03-20