[1]国钰梅,马 龙,包成月,等.急性缺血性脑卒中患者尿酸水平与出院结局的关联研究[J].现代检验医学杂志,2015,30(03):17-20.[doi:10.3969/j.issn.1671-7414.2015.03.005]
　GUO Yu-mei,MA Long,BAO Cheng-yue,et al.Relationship between Uric Acid Levels in Patients with Acute Ischemic Stroke and Discharged Outcome[J].Journal of Modern Laboratory Medicine,2015,30(03):17-20.[doi:10.3969/j.issn.1671-7414.2015.03.005]
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急性缺血性脑卒中患者尿酸水平与出院结局的关联研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
17-20
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Relationship between Uric Acid Levels in Patients with Acute Ischemic Stroke and Discharged Outcome
文章编号:
1671-7414(2015)03-017-04
作者:
国钰梅1; 马 龙1; 包成月1; 黄泽宇2; 李方睿1; 杨丽荣1; 白文婷1; 程 慧1; 刘文波1; 吕利英1;  佟伟军2; 周 蓦2; 李红美2; 许 锬2
1.兴安盟人民医院,内蒙古乌兰浩特 137400;
2.苏州大学医学院公共卫生学院流行病学与统计学系,江苏苏州 215123
Author(s):
GUO Yu-mei1; MA Long1; BAO Cheng-yue1; HUANG Ze-yu2; LI Fang-rui1; YANG Li-rong1;  BAI Wen-ting1; CHENG Hui1; LIU Wen-bo1; LU Li-ying1; TONG Wei-jun2; ZHOU Mo2;  LI Hong-mei2; XU Tan2
1.Xinganmeng People's Hospital,Nei Monggol Autononmous Region Ulanhot 137400,China;
2.Department of Epidemiology &Statistics, School of Public Health,Medical College of Soochow University,Jiangsu Suzhou 215123,China
关键词:
急性缺血性脑卒中;  尿酸;  出院结局
分类号:
R743.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.03.005
文献标志码:
A
摘要:
目的 探讨急性缺血性脑卒中患者入院时不同尿酸水平与出院结局的关系。方法 采用回顾性队列研究的方法,连续性纳入内蒙古兴安盟人民医院2009年6月1日～2012年5月31日的全部急性缺血性脑卒中患者为研究对象,共计3 440例。结局不良定义为发生残疾或住院期间死亡。残疾的定义参照(modified rankin's scale,MRs)脑卒中量表,评分在3分及其以上者(MRs≥3)定义为残疾。采用尿酸水平的百分位数P20,P60和P90为界点将研究对象分为4组,危险因素的分析采用两分类非条件logistic回归方法,计算比值比(odds ratio,OR)及95%可信区间(95% confident interval,95%CI)。所有检验均为双侧检验,检验水准α=0.05。结果 研究对象中发生不良结局的共359人,占10.44%。单因素logistic回归分析显示,相对最低分位组(UA≤222.6 mmol/L),处于二,三分位组(UA水平为222.7～310.9 mmol/L和311.0～419.7 mmol/L)发生结局不良的OR(95%CI)为0.70(0.53～0.91)(P＜0.05)和0.66(0.49～0.88)(P＜0.05)。最高分位组相对最低分位组OR值无统计学差异。在调整了年龄、体温、高血压、高血糖、脑卒中病史、高三酰甘油、高低密脂蛋白胆固醇和吸烟后,相对于最低分位组,依然有处于二,三分位组发生结局不良的OR(95%CI)为0.70(0.53～0.93)(P＜0.05)和0.66(0.48～0.90)(P＜0.05)。最高分位组相对最低分位组OR值差异无统计学意义。结论 急性缺血性脑卒中患者入院时较高的尿酸水平可能独立的与出院结局良好有关联。
Abstract:
Objective To examine the association between uric acid(UA)levels of patients with acute ischemic stroke at admission and discharged outcome.Methods The acute ischemic stroke patients of Xinganmeng People's Hospital in Inner Mongolia,from June 1,2009 to May 31,2012 were continuity included in the present study,the included analysis sample size were 3 440 cases.Poor discharged outcome was defined as the occurrenceof disability or death.With reference to the Modified Rankin's Scale(MRs)Stroke Scale,Scores were recorded in the questionnaires,score of 3 or more( MRs≥3)was defined as disability.The patients were all grouped by P20,P60,P90 of UA,binary logistic regression were used in studying of risk factors,calculated the odds ratios(Odds ratio,OR)and 95% confidence interval(95% Confident interval,95%CI).All tests were two-sided test and a significance level of 0.05.Results A total of 359 people occurred poor outcomes in the study,accounting for 10.44%.Univariate logistic regression analysis ofpoor outcome occurred showed that relative to the lowest group(P20,UA≤222.6 mmol/L),the second and third group(UA:222.7～310.9 mmol/L and 311.0～419.7mmol/L)OR(95% CI)were:0.70(0.53～0.91)(P＜0.05)and 0.66(0.49～0.88)(P＜0.05).After adjusted age,body temperature,high blood pressure,hyperglycemia,history of stroke,high triglycerides,high LDL-C and smoking,relative to the lowest level group,the second and third group occurred poor outcoming OR(95% CI)were:0.70(0.53～0.93)(P＜0.05)and 0.66(0.48～0.90)(P＜0.05).Conclusion Higher levels of uric acid levels in patients with acute ischemic stroke may independently related with occurred poor discharged outcome.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(项目批准号:81172760)。
作者简介:国钰梅(1962-),女,本科学历,主任检验师,研究方向为临床医学检验,Tel:13847992738,E-mail:xamyygym@sina.com。
通讯作者:许 锬,E-mail: xutan@suda.edu.cn。
更新日期/Last Update: 2015-06-10