[1]胡 娟,徐 鹏,呼永河,等.不同海拔高度人群胃蛋白酶原血清水平差异性分析[J].现代检验医学杂志,2015,30(03):32-34.[doi:10.3969/j.issn.1671-7414.2015.03.009]
　HU Juan,XU Peng,HU Yong-he,et al.Analysis on Variations of Serum Pepsinogen in Different Altitude Population[J].Journal of Modern Laboratory Medicine,2015,30(03):32-34.[doi:10.3969/j.issn.1671-7414.2015.03.009]
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不同海拔高度人群胃蛋白酶原血清水平差异性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
32-34
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Analysis on Variations of Serum Pepsinogen in Different Altitude Population
文章编号:
1671-7414(2015)03-032-03
作者:
胡 娟1; 徐 鹏1; 呼永河2; 林 薇3
1.成都军区临床医学检验中心,成都 610083;
2.成都军区总医院,成都 610083;
3.第三军医大学研究生管理大队,重庆 400038
Author(s):
HU Juan1; XU Peng1; HU Yong-he2; LIN Wei3
1.Medical Laboratory Center of Chengdu Military Command, Chengdu 610083,China;
2.General Hospital of Chengdu Military Command,Chengdu 610083, China;
3.Postgraduate Team of the Third Military Medical University,Chongqing 400038,China
关键词:
胃蛋白酶原;  高原;  氧分压;  胃病
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2015.03.009
文献标志码:
A
摘要:
目的 了解在不同海拔高度人群血清中胃蛋白酶原(pepsinogen,PG)含量的变化情况。方法 采集不同海拔地区人群的血液标本进行PG血清含量检测,根据海拔高度不同进行分组比较,PGR为PGI与PGII的比值,对检测数据比较采用独立样本t检验。结果 1 000米组PGI,PGII和PGR结果数据分别为136.892±2.64 μg/L,10.05±5.14 μg/L和13.07±7.41,与1 300米组(分别为130.87±48.66 μg/L,11.55±2.78 μg/L和12.89±4.76)比较PGI与PGII差异有统计学意义(P＜0.05),而PGR差异无统计学意义(P＞0.05); 1 500米组上述各项数据分别是126.64±29.84 μg/L,12.18±5.99 μg/L和12.2±14.84,与1 000米组及1 300米组比较PGI与PGII差异均有统计学意义(P＜0.05),PGR差异无统计学意义(P＞0.05); 其中PGI血清水平与海拔高度呈负相关,PGII血清水平与海拔呈正相关。结论 研究发现随着海拔的升高人们的PGI血清含量会降低,而人PGII的血清含量会随海拔升高而升高,该海拔地区的氧分压不同可能是影响PG水平变化的主要原因。
Abstract:
Objective To compare the serum pepsinogen(PG)in different altitude population.Methods By testing serum PG of people from different altitudes,detected the concentration of serum PG.Results The serum PGI,serum PGII and PGR were respectively 136.89±22.64 μg/L,10.05±5.14 μg/L and 13.07±7.41 in 1 000 m group,and they were 30.87±48.66 μg/L,11.55±2.78 μg/L and 12.89±4.76 in 1 300 m group.There were significant difference in PGI and PGII(P＜0.05)except PGR(P＞0.05)between the two groups.The corresponding indices in 1500m group(126.64±29.84 μg/L,12.18±5.99 μg/L and 12.2±14.84,respectively),the serum PGI was decreased obviously compared with those groups(P＜0.05),the serum PGII was increased obviously compared with those groups(P＜0.05),No significant difference was found when compared with thosegroups(P＞0.05).The serum PGI was negative correlated with higher altitudes,the serum PGII was positively correlated with higher altitudes.Conclusion The study found that the serum PGI content would reducewith the increase of altitude,and on the contrary the serum PGII would risewith the increase of altitude.The main reason that the serum PG change may be influenced by oxygen partial pressure.

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备注/Memo

备注/Memo:
基金项目:国家高技术研究发展计划(“863”计划,2006AA020905); 全军医学科技“十二五”重点项目(BWS11J067)。
作者简介:胡 娟(1959-),女,博士,主任技师,主要从事临床检验医学和流行病学研究工作,Tel:028-86571260,E-mail:13880731591@163.com。
更新日期/Last Update: 2015-06-10