[1]黄健云,芮勇宇,莫和国,等.基层医院ICU鲍曼不动杆菌的感染现况及耐药性分析[J].现代检验医学杂志,2015,30(03):101-103.[doi:10.3969/j.issn.1671-7414.2015.03.029]
　HUANG Jian-yun,RUI Yong-yu,MO He-guo,et al.Survey on Acinetobacter Baumannii Infection and Analysis of Drug Susceptibility in ICU[J].Journal of Modern Laboratory Medicine,2015,30(03):101-103.[doi:10.3969/j.issn.1671-7414.2015.03.029]
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基层医院ICU鲍曼不动杆菌的感染现况及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
101-103
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Survey on Acinetobacter Baumannii Infection and Analysis of Drug Susceptibility in ICU
文章编号:
1671-7414(2015)03-101-03
作者:
黄健云1; 芮勇宇2; 莫和国1; 黎泳仪1; 陆小琴1; 欧水连1; 邴晏如1
1.南方医科大学附属小榄医院检验科,广东中山 528415;
2.南方医科大学南方医院检验医学科,广州 510515
Author(s):
HUANG Jian-yun1; RUI Yong-yu2; MO He-guo1; LIYong-yi1; LU Xiao-qin1; OU Shui-lian1;  BING Yan-ru1
1.Department of Clinical Laboratory,XiaolanHospital Affiliated to South Medical University,Guangdong Zhongshan 528415,China;
2.Department of Medicine Laboratory,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
关键词:
鲍曼不动杆菌;  抗药性;  抗生素;  多重耐药性
分类号:
R378.2; R446.5
DOI:
10.3969/j.issn.1671-7414.2015.03.029
文献标志码:
A
摘要:
目的 了解基层医院ICU鲍曼不动杆菌(Acinetobacter baumannii,Ab)的感染现状和评价《抗菌药物临床应用专项整治活动方案》的实施效果,为临床医生合理应用抗菌药物提供科学依据。方法 用VITEK2微生物分析系统对小榄医院2012年1月～2013年12月ICU患者标本中分离的鲍曼不动杆菌进行药敏分析,比较分析《抗菌药物临床应用专项整治活动方案》2012年(干预前)和2013年(干预后)ICU鲍曼不动杆菌的耐药性。结果 2012年(干预前)和2013年(干预后)从小榄医院ICU标本分离的鲍曼不动杆菌分别为71株和57株,其主要来源于呼吸系统感染,分别占94.4%和84.2%。该项方案干预后,多重耐药鲍曼不动杆菌的检出率由77.5%降为66.7%; 鲍曼不动杆菌对头孢吡肟、头孢他啶、头孢曲松、妥布霉素和复方新诺明等的耐药率显著降低(χ2＞3.84,P＜0.05)。结论 该项方案干预后,ICU患者标本分离的鲍曼不动杆菌对常用14种抗菌药物的耐药率低于干预前,其中有5种抗菌药物的耐药率显著降低。
Abstract:
Objective To investigate the current situationon the infection of Acinetobacter baumannii in ICU and evaluate the efficiency of resistance control project which was performed in Xiaolan hospital,so as to provide scientific basis for clinical rational use of antibiotics.Methods Used VITEK-2 microbiology analysis system for the pathogen identification and drug sensitivity.Compared drug resistance of Acinetobacter baumannii isolated from the samples of ICU patients in 2012(before the project executed)with that in 2013(after the project executed).Results 71 strains and 57strains Acinetobacter baumannii were isolated from the ICU in 2012(before the project executed)and in 2013(after theproject executed)respectively,which majorly isolated from the samples of respiratory system,and occupied 94.4% and 84.2% respectively.The infection rate of multi-resistant Acinetobacter baumannii was decreased from 77.5% to 66.7%,and the resistance rate of Acinetobacter baumannii to cefepime,ceftazidime,cefatriaxone,tobramycin and cotrimoxazole decreased distinctly after theimplementation of drug resistance control management(χ2＞3.84,P＜0.05).Conclusion The drug resistance rates of Acinetobacter baumannii to 14 kinds of routine antibacterial drugs in 2013 were lower thanthat in 2012 in ICU.Among them,the drug resistance rates of Acinetobacterbaumannii to 5 kinds of antibacterial drugs decreased distinctly.

参考文献/References:

[1] 冯海翔.下呼吸道感染非发酵菌的临床分布及耐药性分析[J].现代检验医学杂志,2013,28(04):155-156,158.
Fong HX.Clinical distribution and drug resistance of non-fermentedbacili in lower respiratory tract infection[J].Journal of Modern LaboratoryMedicine,2013,28(4):155-156,158.
[2] Ma MY,Xu J,Yu N,et al.Analysis of drug resistance of Acinetobacterbaumannii and its related factors in ICU[J].Chinese Critical Care Medicine,2013,25(11):686-689.
[3] Chopra T,Marchaim D,Awali RA,et al.Epidemiology of bloodstream infections caused by Acinetobacter baumannii and impact of drug resistance to bothcarbapenems and ampicillinsulbactam on clinical outcomes[J].Antimicrob Agents Chemother,2013,57(12):6270-6275.
[4] Gurung J,Khyriem AB,Banik A,et al.Association of biofilm production with multidrug resistance among clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa from intensive care unit[J].Indian J Crit Care Med,2013,17(4):214-218.
[5] 黄健云,陈光辉,王 前,等.多重耐药鲍曼不动杆菌感染情况调查及耐药分析[J].国际检验医学杂志,2012,33(16):1923-1924,1927.
Huang JY,Chen GH,Wang Q,et al.Survey on multi-resistant Acinetobacter Banmannii infection and analysis of drng snsceptibility[J].International Journal of Laboratory Medicin,2012,33(16):1923-1924,1927.
[6] Feng SH,Stojadinovic A,Izadjoo M.Distinctive stages and strain variations of A.baumannii biofilm development under shear flow[J].J Wound Care,2013,22(4):173-174,176-178,180-181.
[7] Rumbo-Feal S,Gómez MJ,Gayoso C,et al.Whole tr-anscriptome analysisof Acinetobacter baumannii assessed by RNA-sequencing reveals different mRNA expression profiles in biofilm compared to planktonic cells[J].PLoS One,2013,8(8):e72968.
[8] Dong R,Guan C,Hu D,et al.The correlation study on antimicrobial resistance and biofilm related genes in clinical isolates of Acinetobacter baumannii[J].Chinese Critical Care Medicine,2013,25(8):493-494.
[9] 王玉平,宋艳荣,李继红,等.60株鲍曼不动杆菌耐药基因携带情况分析[J].基础医学与临床,2010,30(3):297-302.
Wang YP,Song YR,Li JH,et al.Analysis of drug-resistant genes of 60 Ancinetobacter baumannii isolates[J].Basic Medical Sciences and Clinics,2010,30(3):297-302.
[10] Giannouli M,Antunes LC,Marchetti V,et al.Virulence-relatedtraits of epidemic Acinetobacter baumannii strains belonging to the international clonal lineages I-III and to the emerging genotypes ST25 and ST78[J].BMC Infect Dis,2013(13):282.
[11] Breidenslein EB,de la Fuente-Nunez C,Hancock R-E.Pseudomonas aemginosa:all roads lead to resistance[J].Trends Microbiol,2011,19(8):419426.
[12] Femandez L,Breidenstein EB,Hancock RE.Creeping baselines and adativeresistance to antibiotics[J].Dnlg Resist updat,20ll,14(1):1-21.
[13] 唐吉斌,章 文,胡志军,等.2009～2011年铜陵地区鲍曼不动杆菌医院感染的临床分布及耐药性[J].现代检验医学杂志,2012,27(6):61-63,66.
Tang JB,Zhang W,Hu ZJ,et al.Analysis of clinical distribution and drug resistance of Acinetobacter baumannii in nosocomial infection from 2009 to2011 in Tongling[J].Journal of Modern Laboratory Medicine,2012,27(6):61-63,66.
[14] 归巧娣,苍金荣,刘 英,等.2010～2012年鲍曼不动杆菌耐药监测结果分析[J].现代检验医学杂志,2013,28(4):139-140,142.
Gui QD,Cang JR,Liu Y,et al.Analysis of drug resistance of Acinetobcter baumanii from 2010 to 2012[J].Journal of Modern Laboratory Medicine,2013,28(4):139-140,142.

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备注/Memo

备注/Memo:
基金项目:中山市医学科研基金项目(N0:2009063)。
作者简介:黄健云(1976-),女,大学本科,学士学位,副主任技师,研究方向:医院感染控制,Tel:13326966386,E-mail:huangjianyun1102@sina.com。
通讯作者:芮勇宇(1970-),男,硕士研究生,研究员,Tel:13729852982,E-mail:yongyuruigroup@sina.com。
更新日期/Last Update: 2015-06-10