[1]伍香梅.慢性荨麻疹患者外周血IL-17和IL-23的表达及临床意义[J].现代检验医学杂志,2015,30(05):102-104.[doi:10.3969/j.issn.1671-7414.2015.05.031]
 WU Xiang-mei.Expression Levels and Significance of IL-17 and IL-23 in Peripheral Blood of Patients with Chronic Urticaria[J].Journal of Modern Laboratory Medicine,2015,30(05):102-104.[doi:10.3969/j.issn.1671-7414.2015.05.031]
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慢性荨麻疹患者外周血IL-17和IL-23的表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
102-104
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Expression Levels and Significance of IL-17 and IL-23 in Peripheral Blood of Patients with Chronic Urticaria
作者:
伍香梅
荆门市康复医院皮肤科,湖北荆门448000
Author(s):
WU Xiang-mei
Department of Dermatological,Rehabilitation Hospital of Jingmen,Hubei Jingmen 448000,China
关键词:
慢性荨麻疹变态反应免疫炎症因子
分类号:
R758.24;R392.11
DOI:
10.3969/j.issn.1671-7414.2015.05.031
文献标志码:
A
摘要:
目的分析慢性荨麻疹患者外周血IL-17,IL-23的表达及临床意义。方法分析2009年1月~2013年1月在荆门市康复医院接受治疗的慢性荨麻疹患者的临床资料,并列为观察组。另纳入同期健康体检者作为对照组。结果该研究共纳入研究对象91例,其中观察组患者61例,对照组30例。观察组患者外周血IL-17及IL-23水平显著高于对照组,相比较差异具有统计学意义(P<0.001)。Pearson相关性检验显示:观察组患者外周血IL-23与IL-17水平呈现显著正相关,差异具有统计学意义(r=0.504,P<0.001)。经4周治疗后,观察组患者外周血IL-17水平显著降低,与治疗前比较差异具有统计学意义(65.31±18.75pg/ml vs 121.53±31.19 pg/ml,t=10.710,P<0.001)。以治疗后IL-17水平的中位数(66.79 pg/ml)为界,将患者分为A(IL-17<66.79 pg/ml),B(IL-17≥66.79 pg/ml)两组。Kaplan-Meier分析显示:治疗后1年,A组患者累积复发率显著低于B组,相比较差异具有统计学意义[13.79%,(4/29) vs 37.93%,(11/29)Log-rank χ2=4.344,P=0.037]。结论慢性荨麻疹患者外周血IL-17,IL-23表达升高,且可以一定程度判断预后。
Abstract:
ObjectiveTo analyze the expression levels and significance of IL-17 and IL-23 in peripheral blood of patients with chronic urticaria.MethodsClinical data of patients with chronic urticaria received treatment at Rehabilitation Hospital of Jingmen from 2009 to 2013 was analyzed as group A.Healthy controls were enrolled as group B.ResultsA total of 152 patients were analyzed,group A 61 cases,group B 30 cases.Group A patients had higher levels of IL-17 and IL-23 than these of group B patients,the difference was statistically significant (P<0.05).Correlation analysis showed that,for group A patients,the levels of IL-17 had significant positive correlation with IL-23 (r=0.504,P<0.001).Group A patients were divided into two subgroups by the levels of IL-17,group A1 (IL-17<66.79 pg/ml) and group A2 (IL-17≥66.79 pg/ml).Kaplan-Meieranalysis showed that group A1 patients had a lower recurrence rate than that of group A2 and the difference was statistically significant [13.79%,(4/29) vs 37.93%,(11/29) Log-rank χ2=4.344,P=0.037].ConclusionThe high expression of IL-17 and IL-23 in peripheral blood of patients with chronic urticarial may play a role in the pathogenesis of chronic urticarial.

参考文献/References:

[1]李春萍,沈小霞.西安地区慢性荨麻疹和慢性湿疹患者变应原检测结果分析[J].现代检验医学杂志,2014,29(3):146-148. Li CP,Shen XX.Analysis of allergen test results of patients with chronic urticaria and eczema in Xi’an[J].Journal of Modern Laboratory Medicine,2014,29(3):146-148.
[2]Heffler E,Bruna E,Rolla G.Chronic urticaria in a celiac patient:role of food allergy[J].J Investig Allergol Clin Immunol,2014,24(5):356-357.
[3]罗颖,晏洪波,周凌,等.慢性荨麻疹患者红细胞补体受体1分子表达及外周血IgE和补体C3,C4水平的相关性研究[J].中华皮肤科杂志,2012,45(12):855-858. Luo Y,Yan HB,Zhou L,et al.Expression of complement receptor type 1 on erythrocytes and its correlation with immunoglobulin E,complement C3 and C4 expressions in patients with chronic urticaria[J].Chinese Journal of Dermatology,2012,45(12):855-858.
[4]Jauregui I,Ortiz de Frutos FJ,Ferrer M,et al.Assessment of severity and quality of life in chronic urticaria[J].J Investig Allergol Clin Immunol,2014,24(2):80-86.
[5]Chansakulporn S, Pongpreuksa S, Sangacharoenkit P,et al.The natural history of chronic urticaria in childhood:a prospective study[J].J Am Acad Dermatol,2014,71(4):663-668.
[6]何泽生,安国芝,赵海春.外周血C3,C4与慢性荨麻疹患者病情的相关性[J].中国皮肤性病学杂志,2013,27(1):26-28. He ZS,An GZ,Zhao HC.Investigate chronic urticaria patient’s condition correlating to C3,C4 of peripheral blood[J].The Chinese Journal of Dermatovenereology,2013,27(1):26-28.
[7]Ying S,Kikuchi Y,Meng Q,et al.TH1/TH2 cyto-kines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria:comparison with the allergen-induced late-phase cutaneous reaction[J].J Allergy Clin Immunol,2002,109(4):694-700.
[8]Gao J,Yang A,Chen M,et al.mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria[J].J Biomed Res,2011,25(2):141-147.
[9]Lopes A,Machado D,Pedreiro S,et al.Different frequencies of Tc17/Tc1 and Th17/Th1 cells in chronic spontaneous urticaria[J].Int Arch Allergy Immunol,2013,161(2):155-162.
[10]Azor MH,dos santos JC,Futata EA,et al.Statin effects on regulatory and proinflammatory factors in chronic idiopathic urticaria[J].Clin Exp Immunol,2011,166(2):291-298.
[11]Daschner A,Rodero M,de Frutos C,et al.Different serum cytokine levels in chronic vs.acute Anisakis simplex sensitization-associated urticaria[J].Parasite Immunol,2011,33(6):357-362.
[12]Works MG, Yin FF, Yin CC,et al.Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis[J].J Immunol,2014,193(7):3278-3287.

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备注/Memo

备注/Memo:
作者简介:伍香梅(1972-),女,大学本科,皮肤科副主任医师,研究方向:皮肤病,Tel:15927123421。
更新日期/Last Update: 1900-01-01