[1]景媛媛,李锦,段勇,等.青年献血人群HBV/OBI感染者血清中IL-10表达水平的分析[J].现代检验医学杂志,2015,30(05):107-110.[doi:10.3969/j.issn.1671-7414.2015.05.033]
　JING Yuan-yuan,LI Jin,DUAN Yong,et al.Analysis of IL-10 in Serum of Blood Donors with OBI/HBV Infection among Young Adults[J].Journal of Modern Laboratory Medicine,2015,30(05):107-110.[doi:10.3969/j.issn.1671-7414.2015.05.033]
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青年献血人群HBV/OBI感染者血清中IL-10表达水平的分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
107-110
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Analysis of IL-10 in Serum of Blood Donors with OBI/HBV Infection among Young Adults
作者:
景媛媛; 李锦; 段勇; 蔡斌; 叶世辉
陕西省血液中心，西安710061
Author(s):
JING Yuan-yuan; LI Jin; DUAN Yong; CAI Bin; YE Shi-hui
Shaanxi Blood Center，Xi’an 710061，China
关键词:
白细胞介素-10; 隐匿性乙型肝炎病毒感染; 乙型肝炎病毒
分类号:
R457.12
DOI:
10.3969/j.issn.1671-7414.2015.05.033
文献标志码:
A
摘要:
目的检测乙型肝炎病毒感染者及隐匿性乙型肝炎病毒感染(OBI)者外周血中IL-10的表达水平。方法收集2013年6月~2015年6月期间陕西省血液中心采集的年龄范围在20~40岁的无偿献血者血液标本，选择HBsAg阳性标本作为HBV组；选择HBsAg阴性/HBV DNA阳性，同时经随访排除窗口期的血液标本作为OBI组，采用酶联免疫法(ELISA)检测48例OBI感染者，37例HBV感染者血清中IL-10的水平，并分析其与丙氨酸氨基转移酶(ALT)、乙肝病毒血清学标志物之间的相关性。结果OBI组血清IL-10含量为21.9±0.7 pg/ml，显著低于HBV组40.4±10.4 pg/ml，差异有统计学意义(F=4.062，P=0.047)；OBI组、HBV组血清中ALT含量分别为18.3 ±1.3 U/L和18.4±1.5 U/L，组间差异无统计学意义(F=1.131，P=0.992)。根据ALT水平的高低，进一步将HBV组和OBI组献血者分为ALT≤20 U/L和20 U/L
Abstract:
ObjectiveTo compare the level of cytokines IL-10 and its function in serum of OBI/HBV infected donors in Xi’an．MethodsSelected serum samples from donors aged 20~40 years old in Shaanxi Blood Center from June 2013 to June 2015．Samples with HBsAg positive were divided into HBV group，while samples with HBsAg negative/ HBV DNA positive，excluded from window period，were divided into OBI group．The levels of IL-10 were detected from the serum of 37 HBV donors and 48 OBI donors by ELISA．Also analyzed the correlation between levels of IL-10 and ALT or the five HBV serological markers．ResultsCompared with the HBV donors (40.4±10.4)pg/ml，the levels of IL-10 of OBI donors (21.9±0.7)pg/ml were significantly decreased (F=4.062，P=0.047)．The level of ALT had no significant difference between OBI group (18.3 ±1.3)U/L and HBV group (18.4±1.5)U/L．The express level of IL-10 had no significant difference between ALT≤20 U/L and 20 U/L

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：陕西省自然科学基金，项目编号：2013JQ4041，资助单位：陕西省科学技术厅。 作者简介：景媛媛(1981-)，女，博士研究生，主管技师，主要研究隐匿性乙肝的发病机制，Tel：029-85257825，E-mail：yuanyuanjing1010@126.com。 通讯作者：叶世辉(1960-)，男，主任医师，主要从事血液质量管理和输血安全研究，Tel：029-85232598，E-mail： yeshhui@126.com。
更新日期/Last Update: 1900-01-01