[1]白利芬,赵冬,李慧,等.总胆汁酸和前清蛋白在肝炎及肝炎后肝硬化中的临床意义[J].现代检验医学杂志,2015,30(05):162-163.[doi:10.3969/j.issn.1671-7414.2015.05.052]
　BAI Li-fen,ZHAO Dong,LI Hui,et al.Study on the Clinical Significance of Total Bile Acids and Prealbumin in Hepatitis and Liver Cirrhosis[J].Journal of Modern Laboratory Medicine,2015,30(05):162-163.[doi:10.3969/j.issn.1671-7414.2015.05.052]
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总胆汁酸和前清蛋白在肝炎及肝炎后肝硬化中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
162-163
栏目:
检验与临床
出版日期:
2015-12-10

文章信息/Info

Title:
Study on the Clinical Significance of Total Bile Acids and Prealbumin in Hepatitis and Liver Cirrhosis
作者:
白利芬; 赵冬; 李慧; 王兴宁
延安大学医学院附属医院检验科，陕西延安716000
Author(s):
BAI Li-fen; ZHAO Dong; LI Hui; WANG Xing-ning
Department of Clinical Laboratory， Affiliated Hospital of Yan’an University Medical College，Shaanxi Yan’an 716000，China
关键词:
总胆汁酸; 前清蛋白; 肝炎; 肝炎后肝硬化
分类号:
R512.6；R446.112
DOI:
10.3969/j.issn.1671-7414.2015.05.052
文献标志码:
A
摘要:
目的回顾性分析总胆汁酸(TBA)、前清蛋白(PA)在肝炎和肝炎后肝硬化诊断中的临床意义。方法收集延安大学附属医院2013年7~12月感染病科住院并确诊的肝病患者97例为观察组，其中肝炎组53例，肝炎后肝硬化组44例。收集同期健康体检者50例作为对照组。三组分别进行TBA和PA检测，TBA采用循环酶法，PA采用免疫比浊法。结果肝炎组TBA水平(15.20±20.22 μg/L)和肝炎后肝硬化组TBA水平(39.40±34.09 μg/L)均高于对照组(3.15±2.37 μg/L)，二者与对照组分别比较，差异具有统计学意义(q=3.89，11.11，P<0.05)；肝炎后肝硬化组的TBA高于肝炎组，差异具有统计学意义(q=7.17，P<0.05)。肝炎组PA水平(224.23±69.34 mg/L)和肝炎后肝硬化组PA水平(167.37±62.41 mg/L)均低于对照组(294.44±38.44 mg/L)，二者与对照组分别比较，差异具有统计学意义(q=8.69，15.03，P<0.05)。肝炎后肝硬化组TBA，PA的阳性率(65.91%，77.27%)明显高于肝炎组(20.75%，39.6%)和对照组(2.00%，4.00%)的阳性率，差异均有统计学意义(P<0.05)。肝炎组TBA，PA的阳性率明显高于对照组，差异有统计学意义(P<0.05)。结论TBA和PA水平直接反映肝脏功能减退与损伤程度，其阳性率可作为肝病诊断的重要指标。
Abstract:
ObjectiveTo retrospectively analysed clinical significance of total bile acids and prealbumin in hepatitis and posthepatitic cirrhosis．MethodsCollected 97 definite patients with liver disease from July to December in 2013．Among them 53 cases were hepatitis patients，44 cases were posthepatitic cirrhosis patients．Meanwhile，collected 50 healthy serum as control group，TBA detection and PA detection were respectively carried on．Enzymatic cycling assay was used in PBA detection，immunoturbidimetry assay was used in PA detection．ResultsThe value of TBA of hepatitis patients (15.20±20.22 μg/L) and posthepatitic cirrhosis patients (39.40±34.09 μg/L) were all higher than the control group (3.15±2.37 μg/L)．Separately were all compared with control group，the difference was statistically significant (q=3.89，11.11，P<0.05)．The values of TBA of posthepatitic cirrhosis patients were all higherthan the hepatitis patients，the difference was statistically significant (q=7.17，P<0.05)．The value of PA of hepatitis patients (224.23±69.34 mg/L) and posthepatitic cirrhosis patients (167.37±62.41 mg/L) were all lower than the control group (294.44±38.44 mg/L)．Separately were all compared with control group，the difference was statistically significant (q=8.69，15.03，P<0.05)．The positive rate of TBA and PA of hepatitis patients was obviously higher than the control group，and the difference was statistically significant (P<0.05)．ConclusionThe value of TBA and PA was a direct reflection of the degree of injury of liver function．Its positive rate can be regarded as an important indicator of liver disease diagnosis．

参考文献/References:

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备注/Memo

备注/Memo:
作者简介：白利芬(1972－)，女，本科，主管检验师，主要从事职业病与临床检验工作，Tel：0911-2811299，E-mail：lifenb@163.com。 通讯作者：赵冬，主管检验师，Tel：0911-2881136，E-mail：lifenb@163.com。
更新日期/Last Update: 1900-01-01