[1]段发兰,李亚新,杨飞翔,等.CT与FIB-4无创诊断慢性乙型病毒性肝炎肝纤维化的效果分析[J].现代检验医学杂志,2015,30(06):119-120.[doi:10.3969/j.issn.1671-7414.2015.06.036]
 DUAN Fa-lana,LI Ya-xinb,YANG Fei-xianga,et al.Analysis of CT and FIB-4 Noninvasive Diagnosis in Liver Fibrosis with Chronic Hepatitis B[J].Journal of Modern Laboratory Medicine,2015,30(06):119-120.[doi:10.3969/j.issn.1671-7414.2015.06.036]
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CT与FIB-4无创诊断慢性乙型病毒性肝炎肝纤维化的效果分析()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
119-120
栏目:
检验与临床
出版日期:
2015-12-30

文章信息/Info

Title:
Analysis of CT and FIB-4 Noninvasive Diagnosis in Liver Fibrosis with Chronic Hepatitis B
作者:
段发兰1a李亚新1b杨飞翔1a李毅1a王小波2
1.湖北医药学院附属东风医院 a.检验科;b.综合医疗科,湖北十堰442000;2.湖北医药学院,湖北十堰442000
Author(s):
DUAN Fa-lan1a,LI Ya-xin1b,YANG Fei-xiang1a,LI Yi1a,WANG Xiao-bo2
1a.Department of Clinical Laboratory;1b.Department of Comprehensive Medical, Dongfeng Hospital Affiliated to Hubei University of Medicine,Hubei Shiyan 442000,China; 2.Hubei University of Medicine,Hubei Shiyan 442000,China
关键词:
血清学无创诊断慢性乙型病毒性肝炎肝纤维化
分类号:
R512.62;R446
DOI:
10.3969/j.issn.1671-7414.2015.06.036
文献标志码:
A
摘要:
目的分析CT与FIB-4无创诊断慢性乙型病毒性肝炎肝纤维化的准确性,并与肝组织活检进行比较,为临床无创诊断肝纤维化提供新的手段。方法连续选取湖北医药学院附属东风医院2012年5月~2014年5月收治的46例慢性乙型病毒性肝炎肝纤维化患者为研究对象,其中男性24例,平均年龄46.5±7.3岁,平均病程3.4±1.8年,平均HBV-DNA(49.4±5.3)×102 copies/ml。经该院伦理委员会批准及患者知情同意下均对其实施CT与FIB-4无创检查,并将结果与肝组织活检进行比对。结果CT与FIB-4无创检查与肝组织活检具有良好的一致性(CT:r=0.580,P=0.034;FIB-4:r=0.885,P=0.027);且FIB-4无创检查结果(包括AUC、截断值、敏感度、特异度、阳性预测值、阴性预测值和准确性)均优于CT检查,差异具有统计学意义(P<0.05)。结论FIB-4无创诊断慢性乙型病毒性肝炎肝纤维化效果可能成为替代肝组织活检的一种诊断方法,值得在临床中推广使用。
Abstract:
ObjectiveTo study the accuracy of CT and FIB-4 noninvasive diagnosis compared to liver biopsy in liver fibrosis with chronic hepatitis B.MethodsA total of 46 consecutives of chronic hepatitis B from May 2012 to May 2014,24 males,the mean age was 46.5±7.3 years, mean disease course was 3.4±1.8 years,mean HBV-DNA (49.4±5.3)×102 copies/ml in which,then they were all received CT and FIB-4 noninvasive diagnosis,then compared to liver biopsy.ResultsThe effects of CT and FIB-4 noninvasive diagnosis were good consistency (CT:r=0.580,P=0.034;FIB-4:r=0.885,P=0.027).What’s more,the AUC,cutoff value,sensitivity,specificity,positive predictive value,and negative predictive value and accuracy of FIB-4 were all significantly better than CT (P<0.05).ConclusionThe FIB-4 noninvasive diagnosis may be an alternative means for diagnosing liver fibrosis with chronic hepatitis B compared to liver biopsy.

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备注/Memo

备注/Memo:
作者简介:段发兰(1972-),女,本科,副主任技师,主要从事临床免疫和微生物检验工作,Tel:0719-8272366,13972453082,E-mail:duanfl7683@163.com。 通讯作者:李亚新(1966-),男,本科,主任医师,主要从事老年病方面的研究
更新日期/Last Update: 1900-01-01