[1]李陕区a,兰 淼b,赵仁礼,等.蛋白酪氨酸磷酸酶受体D(PTPRD)在食管鳞状细胞癌组织中的表达及其临床意义[J].现代检验医学杂志,2016,31(01):1-4.[doi:10.3969/j.issn.1671-7414.2016.01.001]
 LI Shan-qua,LAN Miaob,ZHAO Ren-li,et al.Expression and Clinical Relations of PTPRD in Esophageal Squamous Cell Carcinoma[J].Journal of Modern Laboratory Medicine,2016,31(01):1-4.[doi:10.3969/j.issn.1671-7414.2016.01.001]
点击复制

蛋白酪氨酸磷酸酶受体D(PTPRD)在食管鳞状细胞癌组织中的表达及其临床意义()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
1-4
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Expression and Clinical Relations of PTPRD in Esophageal Squamous Cell Carcinoma
作者:
李陕区1a兰 淼1b赵仁礼2杨 博1a巩 丽1b韩秀娟1b姚 丽1b朱少君1b张 伟1b
1.第四军医大学唐都医院 a.门诊部; b.病理科,西安 710038; 2.第四军医大学学员旅,西安 710032
Author(s):
LI Shan-qu1aLAN Miao1bZHAO Ren-li2YANG Bo1aGONG Li1bHAN Xiu-juan1bYAO Li1b ZHU Shao-jun1bZHANG Wei1b
1a.Outpatient Department, 1b.Department of Pathology,Tangdu Hospital,the Fourth Military Medical University, Xi'an 710038,China; 2.Company of the Fourth Military Medical University,Xi'an 710032,China
关键词:
蛋白酪氨酸磷酸酶受体食管鳞状细胞癌免疫组织化学预后
分类号:
R735.1; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.01.001
文献标志码:
A
摘要:
目的 探讨蛋白酪氨酸磷酸酶受体(PTPRD)基因表达与食管鳞状细胞癌(ESCC)患者临床病理特征及预后的关系。方法 应用免疫组织化学SP染色法分析236例ESCC标本中PTPRD基因产物表达情况和定位,收集所有患者的临床病理资料并进行了术后5年随访用于统计分析。结果 统计分析显示PTPRD在ESCC组织中的表达明显低于在正常食管鳞状上皮中的表达(22.0% vs 57.2%,P=0.000)。而且PTPRD的表达与分化程度、浸润深度和有淋巴结转移有关。PTPRD的表达强度在分化好的组高于分化差的组(P=0.013),在浸润浅的组高于浸润深的组(P=0.025),在无淋巴结转移组高于有淋巴结转移组(P=0.019)。PTPRD的表达强度与性别、年龄无关(P=0.170,0.787)。随访资料生存分析显示PTPRD表达强的患者预后较好。结论 PTPRD与ESCC的发生发展和预后密切相关,可能是ESCC发生相关的新的潜在的抑癌基因,其表达水平可作为估计临床预后的一个可能参考指标。
Abstract:
Objective To identify the expression of PTPRD in esophageal squamous cell carcinoma(ESCC)and analyze its correlation with pathological features and patient survival.Methods Immunohistochemistry analysis was applied to detect the expression level and location ofPTPRD in 236 patients with ESCC.Clinical and pathological features were collected and a 5 years' follow-up after surgery were performed.ResultsStatistic analysis showed that expression of PTPRD in ESCC was lower than in normal esophageal epithelial cells(22.0% vs 57.2%,P=0.000).The expression of PTPRD was correlated to the differentiation grade,depth of tumor invasion and lymph nodes metastasis.The expression of PTPRD was higher in group with well differentiation,less invasion depth and no lymph node metastasis(P=0.013,0.025,0.019).The expression of PTPRD was not correlated to age or gender(P=0.170,0.787).The survival analysis showed that thegroup with more PTPRD expression had better prognosis.Conclusion PTPRD was correlated to progression and prognosis of ESCC.It may be anew potential tumor suppressor gene of ESCC,and its expression level might maya useful marker for predicting prognosis for ESCC patients.

参考文献/References:

[1] Solomon DA,Kim JS,Cronin JC,et al.Mutational inactivation ofPTPRD in glioblastoma multiforme and malignant melanoma[J].Cancer Res,2008,68(24):10300-10306.
[2] Cox,C,Bignell G,Greenman C,et al.A survey of homozygous deletions inhuman cancer genomes[J].Proc Natl Acad Sci USA,2005,102(12):4542-4547.
[3] Sato M,Takahashi K,Nagayama K,et al.Identification of chromosome arm9p as the most frequent target of homozygous deletions in lung cancer[J].Genes Chromosomes Cancer,2005,44(4):405-414.
[4] Stallings RL,Nair P,Maris JM,et al.High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumorsuppressor gene in neuroblastoma[J].Cancer Res,2006,66(7):3673-3680.
[5] Stark M,Hayward N.Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays[J].Cancer Res,2007,67(6):2632-2642.
[6] Purdie KJ,Lambert SR,Teh MT,et al.Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected usingsingle nucleotide polymorphism microarray analysis[J].Genes Chromosomes Cancer,2007,46(7):661-669.
[7] Nagayama K,Kohno T,Sato M,et al.Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution[J].Genes Chromosomes Cancer,2007,46(11):1000-1010.
[8] Weir BA,Woo MS,Getz G,et al.Characterizing the cancer genome in lungadenocarcinoma[J].Nature,2007,450(7171):893-898.
[9] Sjoblom T,Jones S,Wood LD,et al.The consensus coding sequences of human breast and colorectal cancers[J].Science,2006,314(5797):268-274.
[10] Veeriah S,Brennan G,Meng S,et al.The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers[J].Proc Natl Acad Sci U S A,2009,106(23):9435-9440.
[11] Chan TA,Glockner S,Yi JM,et al.Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis[J].PLoS Med,2008,5(5):e114.
[12] Iwasa S,Jin X,Okada K,et al.Increased expression of seprase,a membrane-type serine protease,is associated with lymph node metastasis inhuman colorectal cancer[J].Cancer Lett,2005,227(2):229-236.
[13] Guo Y,Chen Z,Zhang L,et al.Distinctive microRNA profiles relating topatient survival in esophageal squamous cell carcinoma[J].Cancer Res,2008,68(1):26-33.
[14] 杜华阳,李秀娟,范 婕,等.Oct4和Sox2在食管鳞癌组织中的表达及相关性探讨[J].河北北方学院学报(自然科学版),2015,31(1):71-74. Du HY,Li XJ,Fan J,et al.Expressions of Oct4 and Sox2 protein and their correlations in esophageal squamous cell carcinoma[J].Journal of Hebei North University(Natural Science Edition),2015,31(1):71-74.
[15] 陈斯泽,李玉齐,杨 曙,等.HSP90抑制剂对食管鳞癌细胞株TE-1凋亡的影响及作用机制[J].分子影像学杂志,2015,38(3):186-189. Chen SZ,Li YQ,Yang S,et al.Effect of HSP90 inhibitor on apoptosis in esophageal squamous carcinoma cell TE-1 and its mechanism[J].Journal of Melecular Jmaging,2015,38(3):186-189.
[16] 陆寓非,郑晓丽,杨成梁,等.RNAiSurvivin基因表达对食管鳞癌细胞的影响[J].医药论坛杂志,2015,36(9):39-40. Lu YF,Zheng XL,Yang CL,et al.Effects of eso-phageal squamous carcinoma by survivin gene with RNA interference[J].J Medical Fourn,2015,36(9):39-40.
[17] 姚宁华,盖 领,黄 华,等.FoxQ1在食管鳞状细胞癌中的表达及其与预后[J].临床与病理杂志,2015,35(9):1632-1636. Yao NH,Gai L,Huang H,et al.Expression and prognosis of FoxQ1 in esophageal squamous cell carcinoma[J].International Journal of Pathology and ClinicalMedicine,2015,35(9):1632-1636.
[18] Pulido R,Serra-Pages C,Tang M,et al.The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases:multiple human LAR,PTPdelta,and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1[J].Proc Natl Acad Sci USA,1995,92(25):11686-11690.
[19] Tonks NK.Protein tyrosine phosphatases:from ge-nes,to function,to disease[J].Nat Rev Mol Cell Biol,2006,7(11):833-846.
[20] Ostman A, Hellberg C, Bohmer FD.Protein-tyrosine phosphatases and cancer[J].Nat Rev Cancer,2006,6(4):307-320.
[21] Hunter T,Signaling-2000 and beyond[J].Cell,20 00,100(1):113-127.
[22] Solomon DA,Jung-sik K,Cronin JC,et al.Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma[J].Cancer Res,2008,68(24):10300-10306.
[23] Veeriah S,Brennan C,Meng S,et al.The tyrosine phosphatase PTPRD is atumor suppressor that is frequently inactivated and mutated in glioblastoma andother human cancers[J].Proc Natl Acad Sci USA,2009,106(23):9435-9440.

相似文献/References:

[1]王静,王成,张春妮.血清miR-25和miR-100作为食管鳞状细胞癌诊断和预后标志物研究[J].现代检验医学杂志,2015,30(05):17.[doi:10.3969/j.issn.1671-7414.2015.05.006]
 WANG Jing,WANG Cheng,ZHANG Chun-ni.Study on Serum miR-25 and miR-100 as Diagnostic and Prognostic Markers for Esophageal Squamous Cell Carcinoma[J].Journal of Modern Laboratory Medicine,2015,30(01):17.[doi:10.3969/j.issn.1671-7414.2015.05.006]
[2]贾亚旭,王 成,张春妮.血清miR-193a-3p,miR-337-5p和miR-483-5p在食管鳞状细胞癌诊断和预后中的应用[J].现代检验医学杂志,2017,32(02):5.[doi:10.3969/j.issn.1671-7414.2017.02.002]
 JIA Ya-xu,WANG Cheng,ZHANG Chun-ni.Application of Serum miR-193a-3p,miR-337-5p and miR-483-5p in the Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma[J].Journal of Modern Laboratory Medicine,2017,32(01):5.[doi:10.3969/j.issn.1671-7414.2017.02.002]
[3]徐 超,徐 珊,窦  燕,等.食管鳞状细胞癌组织PTOV1,IGBP1的表达与临床病理特征和预后相关性研究[J].现代检验医学杂志,2022,37(03):100.[doi:10.3969/j.issn.1671-7414.2022.03.021]
[4]李智军a,姜海燕b,边 超a,等.LINC01503 调控ERK 磷酸化促进食管鳞状细胞癌放疗抵抗的机制研究[J].现代检验医学杂志,2023,38(02):25.[doi:10.3969/j.issn.1671-7414.2023.02.005 ]
 LI Zhi-juna,JIANG Hai-yanb,BIAN Chaoa,et al.Mechanism of LINC01503 Promotes Radiotherapy Resistance to Esophageal Squamous Cell Carcinoma by Regulating ERK Phosphate Acidization[J].Journal of Modern Laboratory Medicine,2023,38(01):25.[doi:10.3969/j.issn.1671-7414.2023.02.005 ]
[5]钟守平,胡艳正.食管鳞状细胞癌组织中组织定居记忆T细胞分布浸润特征及与免疫治疗预后的关系研究[J].现代检验医学杂志,2025,40(02):11.[doi:10.3969/j.issn.1671-7414.2025.02.003]
 ZHONG Shouping,HU Yanzheng.Study on the Distribution and Infiltration Characteristics of Tissue Resident Memory T Cells in Esophageal Squamous Cell Carcinoma and Its Relationship with Immunotherapy Prognosis[J].Journal of Modern Laboratory Medicine,2025,40(01):11.[doi:10.3969/j.issn.1671-7414.2025.02.003]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(No.81001088; No.81372226)陕西省社发攻关项目(2012K13-01-15),国家高新技术研究发展计划(973)重点项目(No.2009CB521704)。 作者简介:李陕区(1960-),男,硕士,副教授,主要侧重于肿瘤的预防和治疗研究,Tel:029-84777161,E-mail:Liyangbo@fmmu.edu.cn。
更新日期/Last Update: 2016-01-20