[1]白雪梅,于培红,殷召雪,等.中国8个长寿地区40岁以上人群血清SOD,MDA和hsCRP水平与高血压、糖尿病的相关研究[J].现代检验医学杂志,2016,31(01):12-16.[doi:10.3969/j.issn.1671-7414.2016.01.004]
　BAI Xue-mei,YU Pei-hong,YIN Zhao-xue,et al.Investigation and Analysis of the Relationship of Hypertension and Diabetes with Superoxide Dismutase,Malondialdehyde,Hypersensitive C-Reactive Protein in 8 Longevity Areas in China of People Aged 40 and Over[J].Journal of Modern Laboratory Medicine,2016,31(01):12-16.[doi:10.3969/j.issn.1671-7414.2016.01.004]
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中国8个长寿地区40岁以上人群血清SOD,MDA和hsCRP水平与高血压、糖尿病的相关研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
12-16
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Investigation and Analysis of the Relationship of Hypertension and Diabetes with Superoxide Dismutase,Malondialdehyde,Hypersensitive C-Reactive Protein in 8 Longevity Areas in China of People Aged 40 and Over
作者:
白雪梅1; 于培红1; 殷召雪2; 施小明2
1.首都医科大学,北京 100069; 2.中国疾病预防控制中心慢性病防治与社区卫生处,北京 102206
Author(s):
BAI Xue-mei1; YU Pei-hong1; YIN Zhao-xue2; SHIXiao-ming2
1.Capital Medical University, Beijing 100069,China; 2.Division of Chronic Diseases Control and Community Health, Chinese Center for Disease Control and Prevention,Beijing 102206,China
关键词:
增龄;  超氧化物歧化酶;  丙二醛;  超敏C反应蛋白
分类号:
R544.1; R587.1; R446.12
DOI:
10.3969/j.issn.1671-7414.2016.01.004
文献标志码:
A
摘要:
目的 研究中国长寿地区中、老年人超氧化物歧化酶(SOD)、丙二醛(MDA)、超敏C反应蛋白(hsCRP)在增龄过程中的变化和高血压、糖尿病与上述三个指标的关系。方法 以中国8个长寿之乡参加2014年长寿县市“老年人口健康状况的生物医学研究”的居民作为目标对象,有2 467名40岁以上人群参加调查且留取了足量的静脉血,其中40～岁组22名,60～岁组249名,70～岁组521名,80～岁组679名,90～岁组548名,100～岁组448名。采用自行设计的调查表收集社会人口学特征等信息,由临床医生采用统一的检查工具对研究对象进行体检。空腹采集静脉血,检测SOD,MDA,hsCRP和GLU。并比较不同年龄组、不同性别上述三个指标含量的差异和高血压、糖尿病不同患病情况的受试者上述三个指标的差异。结果 40～,60～,70～,80～,90～和100～岁男性SOD分别为55.55±8.82,54.49±6.74,55.47±8.42,56.40±8.37,57.45±8.71和57.38±7.72 U/ml,各组之间的差异有统计学意义(F=3.398,P<0.01),女性为59.36±10.98,56.08±7.98,57.41±8.54,57.38±8.18,59.16±7.71和57.90±8.66 U/ml,各组之间的差异有统计学意义(F=2.667,P<0.01); 男性MDA分别为6.92±4.02,6.10±4.35,5.66±3.83,5.83±3.66,5.39±2.68和4.80±2.34 μmol/L,各组之间的差异无统计学意义(F=2.198,P=0.052),女性MDA分别为8.93±8.20,7.23±4.57,6.47±3.67,6.42±4.12,5.59±2.88和5.85±3.73 μmol/L,各组之间的差异有统计学意义(F=4.434,P<0.01); 男性hsCRP阳性率分别为11.8%(2/17),14.8%(26/176),19.3%(62/322),23.5%(77/327),26.1%(57/218)和43.4%(33/76),各组之间的差异有统计学意义(χ2=29.914,P<0.01); 女性hsCRP阳性率分别为20.0%(1/5),16.4%(12/73),15.6%(31/199),20.7%(73/352),22.7%(75/330)和28.0%(104/372),各组之间的差异有统计学意义(χ2=14.078,P<0.01)。高血压并发糖尿病组、糖尿病组、高血压组、非高血压非糖尿病组SOD分别为55.65±8.73,55.35±7.82,57.32±8.45和57.24±8.01 U/ml,各组之间的差异有统计学意义(F=3.694,P=0.011); MDA分别为6.67±4.79,5.16±2.70,6.01±3.87和5.66±3.15 μmol/L,各组之间的差异有统计学意义(F=5.594,P=0.001); hsCRP阳性率分别为28.9%(54/187),29.5%(28/95),21.4%(275/1288)和21.2%(181/853),各组之间的差异有统计学意义(F=8.749,P=0.033)。结论 ①机体在增龄过程中有保持氧化-抗氧化功能稳定的能力,但体内炎症较为普遍,随着年龄增加,机体发生心血管疾病的机率明显增加。②SOD,MDA,hsCRP与糖尿病、高血压的发生发展密切相关,是临床上反映人体内氧化应激程度可靠的指标。
Abstract:
Objective To investigate the changes of superoxide dismutase(SOD),malondialdehyde(MDA),hypersensitive c-reactive protein(hsCRP)in the process of age changes,in longevity areas in China,and the relationship between the above three indicators and hypertension and diabetes.Methods Residents who participated in the project of biomedical research of aging population conducted in 2014 were selected from 8 longevityAreas in China.2 467 people aged 40 and over attended the study,including 22 aged 40 and over,249 aged 60 and over,521 aged 70 and over,679 aged 80 and over,548 aged 90 and over,448 aged 100 and over.Information,including socio-demographic,were collected by self-designed questionnaire.Calibrated instruments were used by the clinical personnel who had worked over 3 years to manually check subjects' heath.The fasting blood samples were collected by vacuum tube atearly morning.The contents of plasma SOD,MDA,hsCRP and glucose were detectedand compared among these elderly who were classified into different genders anddifferent age groups.At the same time,compare the above three indicators of different subjects of hypertension,diabetes prevalence.Results In the groups aged 40 and over,60 and over,70 and over,80 and over,90and over,100 and over,SOD were 55.55±8.82,54.49±6.74,55.47±8.42,56.40±8.37,57.45±8.71 and 57.38±7.72 U/ml respectively in males,the difference between groups showed statistically significant(F=3.398,P<0.01)and 59.36±10.98,56.08±7.98,57.41±8.54,57.38±8.18,59.16±7.71and 57.90±8.66 U/ml respectively in females,the difference between groupsshowed statistically significant(F=2.667,P<0.01); MDA were 6.92±4.02,6.10±4.35,5.66±3.83,5.83±3.66,5.39±2.68 and 4.80±2.34 μmol/L respectively in males,the difference between groups were not statisticallysignificant(F=2.198,P=0.052)and 8.93±8.20,7.23±4.57,6.47±3.67,6.42±4.12,5.59±2.88 and 5.85±3.73 μmol/L respectively in females,the difference between groups showed statistically significant(F=4.434,P<0.01); positive rates of hsCRP were 11.8%(2/17),14.8%(26/176),19.3%(62/322),23.5%(77/327),26.1%(57/218)and 43.4%(33/76)respectively in males,the difference between groups showed statistically significant(χ2=29.914,P<0.01)and 20.0%(1/5),16.4%(12/73),15.6%(31/199),20.7%(73/352),22.7%(75/330)and 28.0%(104/372)respectively in females,the difference between groups showed statistically significant(χ2=14.078,P<0.01).In the groups of hypertension complicated with diabetes mellitus,hypertension,diabetes mellitus,non-diabetes hypertension SOD were 55.65±8.73,55.35±7.82,57.32±8.45 and 57.24±8.01 U/ml respectively,the difference between groups showed statistically significant(F=3.694,P=0.011).MDA were 6.67±4.79,5.16±2.70,6.01±3.87 and 5.66±3.15 μmol/L respectively,the difference between groups showed statistically significant(F=5.594,P=0.001); positive rates of hsCRP were 28.9%(54/187),29.5%(28/95),21.4%(275/1 288)and 21.2%(181/853)respectively the difference between groups showed statistically significant(F=8.749,P=0.033).Conclusion The results indicated that the body had the ability to keep oxidation-antioxidant function stable in the process of aging.However,with the increase of age,the risk ofcardiovascular disease was significantly increased,and it was more common forthe aged suffering from inflammation.SODS,MDA,hsCRP are closely related to the occurrence of diabetes,high blood pressure,they were the reliable clinical indicators of oxidative stress degree.

参考文献/References:

[l] 俞卓伟, 保志军, 阮清伟,等.氧化应激-炎症-衰老及其与ApoE基因相关性研究进展[J].生理学报,2013,65(3):338-346. Yu ZW, Bao ZJ, Ruan QW,et al.Oxi-inflamm-aging and its association with the polymorphism of ApoE genes[J].Acta Physiologica Sinica,2013,65(3):338-346.
[2] 施小明,殷召雪,钱汉竹,等.我国长寿地区百岁老人慢性病及有关健康指标研究[J].中华预防医学杂志,2010,44(2):101-107. Shi XM, Yin ZX, Qian HZ,et al.A study on chronic diseases and other related health indicators of centenarians in longevity areas in China[J].Chin J Prev Med,2010,44(2):101-107.
[3] 殷召雪,施小明,徐建伟,等.我国长寿地区90岁以上老人血浆超氧化物歧化酶和丙二醛含量及影响因素[J].中华预防医学杂志,2010,44(2):123-127. Yin ZX,Shi XM,Xu JW,et al.Level and effect factors of superoxidedismutase and malondialchehyche of the old people aged 90 and over in longevityregions,China[J].Chin J Prev Med,2010,44(2):123-127.
[4] Soerensen M,Christensen K,Stevnsner T,et al.The Mn-superoxidedismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old[J].Mech Ageing Dev,2009,130(5):308-314.
[5] McFarlin BK,Flynn MG,Campell WW,et al.Physical activity status,but not age,influences inflammatory biomarkers and toll-like receptor 4[J].J Gerontol A Biol Sci Med Sci,2006,61(4):388-393.
[6] 陈 刚.高血压患者及高血压并发DM2患者血清MDA和红细胞中SOD测定的意义[J].放射免疫学杂志,2009,22(3):297-298. Chen G.The significance of determination of serum MDA and SOD in red blood cells of patients with hypertension complicated with DM2[J].Journal of Radioimmunology,2009,22(3):297-298.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(71110107025,71233001,71490732,81273160)。 作者简介:白雪梅(1976-),女,医学学士,主管检验师,主要研究方向:临床化学和免疫学。 通讯作者:于培红,首都医科大学临床检验中心主任,研究方向:临床化学和免疫学,E-mail: yupeihong@ccmu.edu.cn。
更新日期/Last Update: 2016-01-20