[1]张养民,薛飞肖.白细胞介素6-174C/G及-572C/G基因多态性与高血压相关性meta分析[J].现代检验医学杂志,2016,31(01):33-37.[doi:10.3969/j.issn.1671-7414.2016.01.009]
　ZHANG Yang-min,XUE Fei-xiao.Association of Interleukin-6 Gene -174C/G and -572C/G Polymorphisms with Hypertension:A Meta-Analysis[J].Journal of Modern Laboratory Medicine,2016,31(01):33-37.[doi:10.3969/j.issn.1671-7414.2016.01.009]
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白细胞介素6-174C/G及-572C/G基因多态性与高血压相关性meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
33-37
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Association of Interleukin-6 Gene -174C/G and -572C/G Polymorphisms with Hypertension:A Meta-Analysis
作者:
张养民1; 薛飞肖2
1.西安市中心医院输血科,西安 710003; 2.西安市第二医院检验科,西安 710003
Author(s):
ZHANG Yang-min1; XUE Fei-xiao2
1.Department of Blood Transfusion,Xi'an Central Hospital,Xi'an 710003,China; 2.Department of Clinical Laboratory,the Second Hospital of Xi'an,Xi'an 710003,China
关键词:
白细胞介素6;  基因多态性;  高血压;  meta分析
分类号:
R544.1; Q786
DOI:
10.3969/j.issn.1671-7414.2016.01.009
文献标志码:
A
摘要:
目的 研究主要评估白细胞介素6-174C/G及-572C/G基因多态性与高血压患病的相关性。方法 通过以白细胞介素6、高血压、多态性为关键词/摘要,检索中国知网、万方数据库,以英文interleukin-6,polymorphism,IL-6,hypertension,high blood pressure为关键词/摘要,检索PubMed,Web of Science,Google scholar外文数据库,采用随机效应模型合并比值比进行统计。结果 该meta分析共计纳入6篇研究,包含1 041例高血压患者与1 088例健康志愿者,其中-174C/G基因多态性与高血压无显著差异(C vs G:OR=0.50,95% CI=0.22～1.14,P=0.10),且对亚洲人种进行亚组分析时,所有结果与高血压患病率差异无统计学意义(C vs G:OR=0.75,95%CI=0.41～1.38,P=0.36)。-572C/G基因多态性meta分析结果表明,其与高血压患病在亚洲人群中易感性亦无相关关系(C vs G:OR=0.76,95%CI=0.51～1.15,P=0.20)。结论 白细胞介素6-174C/G及-572C/G基因多态性与增加亚洲人群高血压易感性之间无相关性。
Abstract:
Objective To assess the association of interleukin-6(IL-6)-174C/G and -572C/G gene polymorphisms with hypertension risk.Methods The electronic databases,such as Pubmed,Web ofScience,Google scholar,China National Knowledge Infrastrure and Wanfang database were searched by the interleukin-6,polymorphism,IL-6,hypertension,highblood pressure as the keywords/abstract.Random effect model was used to calculate the pooled odds ratio.Results The meta-analysis included 6 studies with 1 041 hypertension cases and 1 088 health subjects,which was no significant association between IL-6-174C/G gene polymorphism and hypertension(C vs G:OR=0.50,95%CI=0.22～1.14,P=0.10),and in the stratified analysis by ethnicity,no significant was found in Asian subgroup(C vs G:OR=0.75,95%CI=0.41～1.38,P=0.36).There was also no association between IL-6-572C/G gene polymorphism and hypertension in Asian(C vs G:OR=0.76,95%CI=0.51～1.15,P=0.20).Conclusion The IL-6-174C/G and -572C/G gene polymorphisms were suggested to be no related tothe increased risk of hypertension in Asian.

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备注/Memo

备注/Memo:
作者简介:张养民(1965-),男,本科, 副主任检验师,从事医学检验及输血工作30年,研究方向:血液免疫学,Tel:13991136831,E-mail:zhangyangmin1234@163.com。
更新日期/Last Update: 2016-01-20