[1]基金项目:0年苏州市社会发展科技项目(SZD0080)。作者简介:史玉娟(987-),女,硕士,等.肿瘤相关性贫血患者Neogenin的表达特点及其与Hepcidin,SF的关联性研究[J].现代检验医学杂志,2016,31(01):71-72,76.[doi:10.3969/j.issn.1671-7414.2016.01.020]
 SHI Yu-juan,LU Ye,WANG Jin-hu,et al.Expression and Significance of Neogenin, Hepcidin and SF in the Anemia Patients with the Tumor[J].Journal of Modern Laboratory Medicine,2016,31(01):71-72,76.[doi:10.3969/j.issn.1671-7414.2016.01.020]
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肿瘤相关性贫血患者Neogenin的表达特点及其与Hepcidin,SF的关联性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
71-72,76
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Expression and Significance of Neogenin, Hepcidin and SF in the Anemia Patients with the Tumor
作者:
基金项目:2013年苏州市社会发展科技项目(SZD2012080)。 作者简介:史玉娟(1987-)硕士现在复旦大学附属上海市第五人民医院主要从事血液病的基础与临床研究工作。 通讯作者:潘湘涛Tel:18915768003E-mail:panxiangtao@csco.org.cn。
苏州大学附属太仓医院,江苏太仓 215400
Author(s):
SHI Yu-juanLU YeWANG Jin-huCHENG XuPAN Xiang-tao
SHI Yu-juan,LU Ye,WANG Jin-hu,CHENG Xu,PAN Xiang-tao
关键词:
再生蛋白 铁调素 铁蛋白 肿瘤相关性贫血
分类号:
R556.9; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.01.020
文献标志码:
A
摘要:
目的 研究肿瘤相关性贫血患者中再生蛋白(Neogenin)的表达特点,以及与铁调素(Hepcidin),血清铁蛋白(SF)的关系及其意义。方法 应用双抗夹心生物素-亲和素-酶联免疫吸附试验方法检测55例肿瘤贫血患者和52例无贫血肿瘤患者的血清Neogenin,Hepcidin和SF水平,并分析它们之间的相互关系。结果 ①贫血组Neogenin为0.77±0.45 ng/ml,明显低于无贫血组(0.98±0.60 ng/ml)(t=2.003 8,P<0.05); Hepcidin则为6.03±4.25 μg/L,显著高于无贫血组(4.51±2.23 μg/L)(t=2.319 5,P<0.05)。②贫血组SF虽也高于无贫血组,但差异无统计学意义(t=1.898 0,P>0.05)。③Hb与Neogenin呈正相关关系(r=0.212 4,t=2.226 4,P<0.05),与Hepcidin呈负相关关系(r=-0.310 1,t=3.345 2,P<0.01),而与SF无相关关系(P>0.05)。④Neogenin与Hepcidin和SF均无明显相关关系(均P>0.05)。但Hepcidin与SF呈正相关关系(r=0.486 6,P<0.01)。结论 肿瘤贫血患者低表达Neogenin,高表达Hepcidin。Neogenin与Hb呈正相关,Hepcidin与Hb呈负相关。Neogenin和Hepcidin在肿瘤贫血的发生发展中起重要的作用。
Abstract:
Objective To study the expression and significance of Neogenin,Hepcidin and serum ferritin(SF)in patients with cancer-related anemia.Methods To test the serum levels of Neogenin,Hepcidin and SF in 107 cases,including 55 cases with cancer-related anemia and 52 cases of non-anemia with tumor by ABC-ELISA.Results ①The serum levels of Neogenin in patients with cancer-related anemia were0.77±0.45 ng/ml,which were lower than 0.98±0.60 ng/ml in non-anemia group(t=2.003 8,P<0.05).The serum levels of Hepcidin in patients with cancer-related anemia were 6.03±4.25 μg/ml,which was higher than 4.51±2.23μg/ml in non-anemia group(t=2.319 5,P<0.05).②There were no difference in patients between anemia and non-anemia(t=1.898 0,P>0.05).③Inpatients with cancer,there were positive correlation between Neogenin and Hb(r=0.212 4,t=2.226 4,P<0.05),there were negtive correlation between Hepcidin and Hb(r=-0.310 1,t=3.345 2,P<0.01),but there were no correlation between SF and Hb(P>0.05).④There were positive correlation between Hepsidin and SF(r=0.486 6,P<0.01).Conclusion There were lower expression of Neogenin,higher expression of Hepcidin inpatients with cancer-related anemia is a complex process.The abnormal expression of Neogenin and Hepcidin which were lead to the loss of use of iron are the key factors attribute to anemia in patients with cancer.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:2013年苏州市社会发展科技项目(SZD2012080)。 作者简介:史玉娟(1987-),女,硕士,现在复旦大学附属上海市第五人民医院,主要从事血液病的基础与临床研究工作。 通讯作者:潘湘涛,Tel:18915768003,E-mail:panxiangtao@csco.org.cn。
更新日期/Last Update: 2016-01-20